DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzy and slp1

DIOPT Version :9

Sequence 1:	NP_477501.1	Gene:	fzy / 34968	FlyBaseID:	FBgn0001086	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_593161.1	Gene:	slp1 / 2543222	PomBaseID:	SPAC821.08c	Length:	488	Species:	Schizosaccharomyces pombe

Alignment Length:	529	Identity:	197/529 - (37%)
Similarity:	274/529 - (51%)	Gaps:	110/529 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SVLSVSYNTSFSGVQAPTK-----------TP----------GKSSEGKTKKS------------ 75
            |.:|.:::|       |||           ||          |:||:..:.||
pombe     8 STISPTFST-------PTKKRNLVFPNSPITPLHQQALLGRNGRSSKRCSPKSSFIRNSPKIDVV 65

  Fly    76 NT-----------TPSKTPGGGDRFIPNRAATNFELAHFLVNKDSGDKSDEENDKATSSNSNESN 129
            ||           ..|:.....|||||:|..|    |:..||..|.|...:.::....:...:.|
pombe    66 NTDWSIPLCGSPRNKSRPASRSDRFIPSRPNT----ANAFVNSISSDVPFDYSESVAEACGFDLN 126

  Fly   130 VQASAHKGDRQKLISEVAQVGDSKGGRILCYQNKAPAAPE------THNNPLKVVYSIKTPISTK 188
            .                         |:|.::..||.|.:      .||.|       :.|:.|.
pombe   127 T-------------------------RVLAFKLDAPEAKKPVDLRTQHNRP-------QRPVVTP 159

  Fly   189 SGSRYIPTTSERILDAPDFINDYYLNLMDWSADNIVAVALGSCVYLWNAQTGNIEQLTEFEEGDY 253
            :..|: .||.||:||||..|:||||||:|||..|:|||||...||:|||.:|::..|.|.:|..|
pombe   160 AKRRF-NTTPERVLDAPGIIDDYYLNLLDWSNLNVVAVALERNVYVWNADSGSVSALAETDESTY 223

  Fly   254 AGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARVGSLAWNSFLVSSGSRDGTIVHH 318
            ..|:.|..:|..|::|...|.|:::|.....:||.|.||.||||.|:||..::|||||.|.|.||
pombe   224 VASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHH 288

  Fly   319 DVRAREHKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGVGTATDPLHKF--NDH 381
            |||...|::.||.||:.|||||.|.:|...||||||||:|.:|.|.|.        :.||  .:|
pombe   289 DVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSS--------IPKFTKTNH 345

  Fly   382 QAAVRALAWCPWQPSTLASGGGTADRCIKFWNVNNGTLMKSVDSKSQVCSLLFSRHYKELISAHG 446
            .|||:|:||||||.:.||:||||.|:.|.|||...|..:.:||:.|||.||::|.|.||::|.||
pombe   346 NAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHG 410

  Fly   447 FANNQLTIWKYPT--MVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWNCFAPD----PL 505
            |.:|.|:||.|.:  :.||.|:..|.:|||..|:||||..:.:|.:||.|:.|..:..|    |:
pombe   411 FPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKRPI 475

  Fly   506 ASKKAVSTS 514
            ...|..|:|
pombe   476 PITKTPSSS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzy	NP_477501.1	WD40	<208..500	CDD:225201	144/295 (49%)
		WD40	216..498	CDD:238121	136/285 (48%)
		WD40 repeat	256..291	CDD:293791	11/34 (32%)
		WD40 repeat	297..332	CDD:293791	19/34 (56%)
		WD40 repeat	337..373	CDD:293791	18/35 (51%)
		WD40 repeat	386..424	CDD:293791	19/37 (51%)
		WD40 repeat	429..467	CDD:293791	19/39 (49%)
		WD40 repeat	473..513	CDD:293791	15/43 (35%)
slp1	NP_593161.1	WD40	<164..487	CDD:225201	157/330 (48%)
		WD40	202..464	CDD:295369	127/269 (47%)
		WD40 repeat	225..261	CDD:293791	11/35 (31%)
		WD40 repeat	266..301	CDD:293791	19/34 (56%)
		WD40 repeat	309..343	CDD:293791	18/41 (44%)
		WD40 repeat	349..388	CDD:293791	20/38 (53%)
		WD40 repeat	393..433	CDD:293791	19/39 (49%)
		WD40 repeat	439..463	CDD:293791	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37459
Inparanoid	1	1.050	330	1.000	Inparanoid score	I519
OMA	1	1.010	-	-		QHG54440
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		oto102069
orthoMCL	1	0.900	-	-		OOG6_101791
Panther	1	1.100	-	-	LDO	PTHR19918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1346
SonicParanoid	1	1.000	-	-		X1762
TreeFam	1	0.960	-	-
	13	12.860