DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzy and cdc20b

DIOPT Version :9

Sequence 1:	NP_477501.1	Gene:	fzy / 34968	FlyBaseID:	FBgn0001086	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_004910413.1	Gene:	cdc20b / 100497347	XenbaseID:	XB-GENE-1013871	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	540	Identity:	177/540 - (32%)
Similarity:	251/540 - (46%)	Gaps:	96/540 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 WKKKLEASLNGSVNTTRSVLSVSYNTSFSGVQAPTKTPGKSSEGKTKKSNTTPSKTPGGGD---- 87
            |  |||...:..|.....::       :.||.   ||.||......|.|....:|||.|..
Frog     3 W--KLEKISSRRVRAEEDMM-------WEGVM---KTLGKDLRWSRKYSMQKMNKTPDGRSSYSR 55

  Fly    88 --RFIPNRAATNFELAHFLVNKDSGDKSDEENDKATSSNSNESNVQ------------------- 131
              |.|..|.|.:...|...|:.......|:......||:.:|...|
Frog    56 FKRSIMKRRACHVPFASSPVSTKWCQNMDQIQGTGLSSSPSEELCQTPEPLVLLPYLTEIPITAI 120

  Fly   132 ------------ASAHKGDR---QKLISE-----------VAQVGDSKGGRILCYQNKAPAAPET 170
                        .||.|..:   :||:|:           :..|.|.|.|..:           .
Frog   121 PDCAQKPPSLKDTSAPKRTQKTSKKLLSQTRLKFLQEQNFLQTVEDFKRGSCI-----------R 174

  Fly   171 HNNPLKV----VYSIKTPISTKSG------SRYIPTTSERILDAPD-------FINDYYLNLMDW 218
            |::.:|:    ....|..:.||..      ::.:...|..||. ||       ..|||||||:||
Frog   175 HDSNIKICEKDTCMWKGCLQTKKNKSLGQKTQKVHICSHTILQ-PDIRLHIIGLHNDYYLNLLDW 238

  Fly   219 SADNIVAVALGSCVYLWNAQTGNIEQLTEFE-EGDYAGSLSWIQEGQILAIGNSTGAVELWDCSK 282
            :::|:||:.|.|..|:::.:...:.|..... ...|..|:|||..|..||||.|:|.|:|||...
Frog   239 NSENLVAIGLKSTAYIFSGENRTVTQKIHLSCPATYVSSVSWISSGTCLAIGTSSGEVQLWDIET 303

  Fly   283 VKRLRVMDGHSARVGSLAWNSFLVSSGSRDGTIVHHDVRAREHKLSTLSGHTQEVCGLKWSTDFK 347
            .||||.|.||.:.||:|:||:.::|||||.|.|.|||||..||.:.||. |.|.:|.||||....
Frog   304 QKRLRNMLGHMSVVGALSWNNHILSSGSRLGHIHHHDVRIAEHHIGTLQ-HKQGICSLKWSPCGN 367

  Fly   348 YLASGGNDNLVNVWSAASGGVGTATDPLHKFNDHQAAVRALAWCPWQPSTLASGGGTADRCIKFW 412
            .||||.:|..:.:|....|.....:..|:.  .|..||:|:.||||...|||.|||..|..|:.|
Frog   368 KLASGSSDGDLKIWPCDPGETKLKSPLLNM--PHPTAVKAMNWCPWLSDTLAVGGGMTDGLIRIW 430

  Fly   413 NVNNGTLMKSVDSKSQVCSLLFSRHYKELISAHGFANNQLTIWKYPTMVKQADLTGHTSRVLQMA 477
            :.|:|..:.|.::.||:||||:....|||::.||.:.||:|||:||:::|..|..||..|||.:|
Frog   431 DTNSGKNIHSANTNSQICSLLWLPQTKELLTGHGPSRNQMTIWQYPSLLKMNDYYGHKGRVLHLA 495

  Fly   478 MSPDGSTVISAGADETLRLW 497
            :|||...:.||.|:.|..:|
Frog   496 LSPDQRRIFSAAANGTANIW 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzy	NP_477501.1	WD40	<208..500	CDD:225201	129/291 (44%)
		WD40	216..498	CDD:238121	122/283 (43%)
		WD40 repeat	256..291	CDD:293791	20/34 (59%)
		WD40 repeat	297..332	CDD:293791	20/34 (59%)
		WD40 repeat	337..373	CDD:293791	12/35 (34%)
		WD40 repeat	386..424	CDD:293791	17/37 (46%)
		WD40 repeat	429..467	CDD:293791	18/37 (49%)
		WD40 repeat	473..513	CDD:293791	11/25 (44%)
cdc20b	XP_004910413.1	WD40	<220..516	CDD:225201	129/299 (43%)
		WD40 repeat	234..270	CDD:293791	11/35 (31%)
		WD40 repeat	275..312	CDD:293791	20/36 (56%)
		WD40 repeat	318..349	CDD:293791	18/30 (60%)
		WD40 repeat	357..396	CDD:293791	12/38 (32%)
		WD40 repeat	404..440	CDD:293791	16/35 (46%)
		WD40 repeat	447..485	CDD:293791	18/37 (49%)
		WD40 repeat	491..517	CDD:293791	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020