DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx5 and Stx5

DIOPT Version :9

Sequence 1:	NP_523582.4	Gene:	Syx5 / 34966	FlyBaseID:	FBgn0011708	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_113892.2	Gene:	Stx5 / 65134	RGDID:	68426	Length:	355	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	181/348 - (52%)
Similarity:	245/348 - (70%)	Gaps:	16/348 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 SQSNYSYPASIPTSSQFYQSKEEPQETEPEPEIFVMAARDRTGEFANAIRSLQARNITRAVNIRD 187
            |::....||:...||........|....|.|. ..|:.||||.||.:|.:|||:|.  ..:....
  Rat    21 SKTQVLSPATAINSSSDIAPLPTPVALVPSPP-DTMSCRDRTQEFLSACKSLQSRQ--NGIQTNK 82

  Fly   188 PRKAKQVQSYSEFMMVARFIGKNIASTYAKLEKLTMLAKKKSLFDDRPQEIQELTYIIKGDLNAL 252
            | .....:..|||.::||.|||::::|:|||||||:|||:||||||:..||:|||||||.|:|:|
  Rat    83 P-ALHATRQCSEFTLMARRIGKDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSL 146

  Fly   253 NQQIARLQDISKDQRRHTNGKHLVSHSSNMVLALQSKLASMSTDFKQILEVRTENLKQQKTRRDQ 317
            |:|||:|||..: .:...:|:||.:||:.:|::|||||||||.|||.:|||||||||||:.||:|
  Rat   147 NKQIAQLQDFVR-AKGSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRNRREQ 210

  Fly   318 FSQGPGPLAAHTVSPSTAKQGSLLLSEENQA---VSIDMGSSDTTPLLSTQTQMAIYDDSDNYVQ 379
            ||:  .|::|..::|:....|.::|..|::|   |:|||...      .|..|:.:.|:.|:|:|
  Rat   211 FSR--APVSALPLAPNNLGGGPIVLGGESRASRDVAIDMMDP------RTSQQLQLIDEQDSYIQ 267

  Fly   380 QRAETMQNIESTIVELGGIFQQLAHMVKEQEEIVERIDTNVADAELNIEAAHGEILKYFQSVSKN 444
            .||:|||||||||||||.||||||||||||||.::|||.||..|:|::||||.|||||||||:.|
  Rat   268 SRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSN 332

  Fly   445 RWLMIKIFGVLIFFFLFFVVFMS 467
            ||||:|||.:||.||:.||||::
  Rat   333 RWLMVKIFLILIVFFIIFVVFLA 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx5	NP_523582.4	SNARE_syntaxin5	379..451	CDD:277197	55/71 (77%)
Stx5	NP_113892.2	Syntaxin-5_N	52..73	CDD:402844	10/21 (48%)
		COG5325	80..324	CDD:227635	138/253 (55%)
		IxM motif, signal for cargo packaging into COPII-coated vesicles. /evidence=ECO:0000250\|UniProtKB:Q13190	245..247		1/1 (100%)
		SNARE_syntaxin5	266..338	CDD:277197	55/71 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344996
Domainoid	1	1.000	228	1.000	Domainoid score	I2409
eggNOG	1	0.900	-	-		E1_KOG0812
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2381
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2420
OMA	1	1.010	-	-		QHG53826
OrthoDB	1	1.010	-	-		D1297427at2759
OrthoFinder	1	1.000	-	-		FOG0003050
OrthoInspector	1	1.000	-	-		oto95983
orthoMCL	1	0.900	-	-		OOG6_102103
Panther	1	1.100	-	-	LDO	PTHR19957
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2031
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770