DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx5 and Stx5a

DIOPT Version :9

Sequence 1:	NP_523582.4	Gene:	Syx5 / 34966	FlyBaseID:	FBgn0011708	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001161271.1	Gene:	Stx5a / 56389	MGIID:	1928483	Length:	355	Species:	Mus musculus

Alignment Length:	370	Identity:	188/370 - (50%)
Similarity:	253/370 - (68%)	Gaps:	43/370 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 RTLSAAAAVVTGNQPGINNDSQSNYSYPASIPTSSQFYQSKEEPQETEPEPEIFVMAARDRTGEF 167
            :.||.|.|:           |.|:.|.|  :||          |....|.|. ..|:.||||.||
Mouse    24 QVLSPATAI-----------SSSSDSTP--LPT----------PVALVPSPP-DTMSCRDRTQEF 64

  Fly   168 ANAIRSLQARNITRAVNIRDP--RKAKQVQSYSEFMMVARFIGKNIASTYAKLEKLTMLAKKKSL 230
            .:|.:|||:|.  ..:....|  ..|:|.   |||.::||.|||::::|:|||||||:|||:|||
Mouse    65 QSACKSLQSRQ--NGIQTSKPALHAARQC---SEFTLMARRIGKDLSNTFAKLEKLTILAKRKSL 124

  Fly   231 FDDRPQEIQELTYIIKGDLNALNQQIARLQDISKDQRRHTNGKHLVSHSSNMVLALQSKLASMST 295
            |||:..||:|||||||.|:|:||:|||:|||..: .:...:|:||.:||:.:|::|||||||||.
Mouse   125 FDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVR-AKGSQSGRHLQTHSNTIVVSLQSKLASMSN 188

  Fly   296 DFKQILEVRTENLKQQKTRRDQFSQGPGPLAAHTVSPSTAKQGSLLLSEENQA---VSIDMGSSD 357
            |||.:|||||||||||:.||:|||:  .|::|..::|:....|.::|..|::|   |:|||...
Mouse   189 DFKSVLEVRTENLKQQRNRREQFSR--APVSALPLAPNNLGGGPIILGAESRASRDVAIDMMDP- 250

  Fly   358 TTPLLSTQTQMAIYDDSDNYVQQRAETMQNIESTIVELGGIFQQLAHMVKEQEEIVERIDTNVAD 422
                 .|..|:.:.|:.|:|:|.||:|||||||||||||.||||||||||||||.::|||.||..
Mouse   251 -----RTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQRIDENVLG 310

  Fly   423 AELNIEAAHGEILKYFQSVSKNRWLMIKIFGVLIFFFLFFVVFMS 467
            |:|::||||.|||||||||:.|||||:|||.:||.||:.||||::
Mouse   311 AQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx5	NP_523582.4	SNARE_syntaxin5	379..451	CDD:277197	55/71 (77%)
Stx5a	NP_001161271.1	Syntaxin-5_N	53..74	CDD:371517	11/20 (55%)
		COG5325	94..324	CDD:227635	135/238 (57%)
		IxM motif, signal for cargo packaging into COPII-coated vesicles. /evidence=ECO:0000250\|UniProtKB:Q13190	245..247		1/1 (100%)
		SNARE_syntaxin5	266..338	CDD:277197	55/71 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841633
Domainoid	1	1.000	228	1.000	Domainoid score	I2488
eggNOG	1	0.900	-	-		E1_KOG0812
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2381
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2484
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53826
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003050
OrthoInspector	1	1.000	-	-		oto92418
orthoMCL	1	0.900	-	-		OOG6_102103
Panther	1	1.100	-	-	LDO	PTHR19957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1315
SonicParanoid	1	1.000	-	-		X2031
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790