DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx5 and stx5a

DIOPT Version :9

Sequence 1:	NP_523582.4	Gene:	Syx5 / 34966	FlyBaseID:	FBgn0011708	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001002333.1	Gene:	stx5a / 436605	ZFINID:	ZDB-GENE-040718-18	Length:	302	Species:	Danio rerio

Alignment Length:	317	Identity:	179/317 - (56%)
Similarity:	237/317 - (74%)	Gaps:	22/317 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 MAARDRTGEFANAIRSLQARNITRAVNIRDPRKAKQVQSYSEFMMVARFIGKNIASTYAKLEKLT 222
            |..||||.||.:|.:|||.|.:....:.:....|  ::..|:|.::|:.|||::::|:|||||||
Zfish     1 MTCRDRTLEFQSACKSLQGRQLQNGTHSKPANNA--LKQRSDFTLMAKRIGKDLSNTFAKLEKLT 63

  Fly   223 MLAKKKSLFDDRPQEIQELTYIIKGDLNALNQQIARLQDISKDQRRHTNGKHLVSHSSNMVLALQ 287
            :|||:||||||:..||:|||||||.|:|:||:|||:|||:.: .|...||:|:.:||:.:|::||
Zfish    64 ILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDLVR-SRSGQNGRHIQTHSNTIVVSLQ 127

  Fly   288 SKLASMSTDFKQILEVRTENLKQQKTRRDQFSQGP---GPLAAHTVSPSTAKQGSLLLSEENQA- 348
            |||||||.|||.:|||||||||||::||:.|||.|   .||.|:..:      .|:|:.:|:::
Zfish   128 SKLASMSNDFKSVLEVRTENLKQQRSRREHFSQAPVSASPLLANNFN------SSVLMQDESRSL 186

  Fly   349 ---VSIDMGSSDTTPLLSTQTQMAIYDDSDNYVQQRAETMQNIESTIVELGGIFQQLAHMVKEQE 410
               |:||| .|...||     |:.:.|:.|:|:|.||:|||||||||||||.|||||||||||||
Zfish   187 GAEVAIDM-DSRANPL-----QLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQE 245

  Fly   411 EIVERIDTNVADAELNIEAAHGEILKYFQSVSKNRWLMIKIFGVLIFFFLFFVVFMS 467
            |.::|||.||.|.|||:|.|||||||||||||.|||||||||.|||.||:.||||::
Zfish   246 ETIQRIDANVDDTELNVEMAHGEILKYFQSVSSNRWLMIKIFLVLIVFFVIFVVFLA 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx5	NP_523582.4	SNARE_syntaxin5	379..451	CDD:277197	59/71 (83%)
stx5a	NP_001002333.1	Syntaxin-5_N	1..20	CDD:288298	11/18 (61%)
		COG5325	<129..271	CDD:227635	88/153 (58%)
		SNARE_syntaxin5	213..285	CDD:277197	58/71 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585965
Domainoid	1	1.000	226	1.000	Domainoid score	I2454
eggNOG	1	0.900	-	-		E1_KOG0812
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2381
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2445
OMA	1	1.010	-	-		QHG53826
OrthoDB	1	1.010	-	-		D1297427at2759
OrthoFinder	1	1.000	-	-		FOG0003050
OrthoInspector	1	1.000	-	-		otm26426
orthoMCL	1	0.900	-	-		OOG6_102103
Panther	1	1.100	-	-	LDO	PTHR19957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1315
SonicParanoid	1	1.000	-	-		X2031
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800