DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5861 and TMEM147

DIOPT Version :9

Sequence 1:	NP_609789.1	Gene:	CG5861 / 34965	FlyBaseID:	FBgn0015338	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_116024.1	Gene:	TMEM147 / 10430	HGNCID:	30414	Length:	224	Species:	Homo sapiens

Alignment Length:	220	Identity:	108/220 - (49%)
Similarity:	149/220 - (67%)	Gaps:	6/220 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTLYHFGNCVAL-LTPYYFTYKYSGLSEYGAFWKCVQAGGIYIFTQLVKMLVLATFFYSDAPS-S 63
            |||:|||||.|| ..||:.|||.||||||.|||||||||..|:|.||.|||.|||||    |: .
Human     1 MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFF----PTWE 61

  Fly    64 SGEFNFFAEILRCSMDIADLLGFALILSRIPGKGHSKLITAGLGWATAEVILSRGIMLWVGARGT 128
            .|.::|..|.::.|:|:|||:|..|::||..|||..|::.|.|||||||:|:||.|.|||||||.
Human    62 GGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGI 126

  Fly   129 EFSWIYILKCLESNVLLVQHITTATLIWLFTRHDLNKALKPLVSLLLAVTVFKGVWLEGMLHILT 193
            ||.|.||...::||:.||.:|..:..:|:.||:||....:|.|.||:.::|:|...:|..:|:.:
Human   127 EFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLCS 191

  Fly   194 IGPWLTVAVKALVAAVIGFCTLHIY 218
            :|.|..:..:|:|..::...||.:|
Human   192 LGSWAALLARAVVTGLLALSTLALY 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5861	NP_609789.1	DUF2053	2..157	CDD:401642	87/156 (56%)
TMEM147	NP_116024.1	DUF2053	2..155	CDD:401642	87/156 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144922
Domainoid	1	1.000	183	1.000	Domainoid score	I3438
eggNOG	1	0.900	-	-		E1_KOG3236
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12330
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3533
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54820
OrthoDB	1	1.010	-	-		D1388283at2759
OrthoFinder	1	1.000	-	-		FOG0006016
OrthoInspector	1	1.000	-	-		oto91045
orthoMCL	1	0.900	-	-		OOG6_105654
Panther	1	1.100	-	-	LDO	PTHR12869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770