DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17328 and ZNF135

DIOPT Version :9

Sequence 1:	NP_609786.2	Gene:	CG17328 / 34962	FlyBaseID:	FBgn0028895	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_009065.1	Gene:	ZNF135 / 7694	HGNCID:	12919	Length:	682	Species:	Homo sapiens

Alignment Length:	455	Identity:	119/455 - (26%)
Similarity:	164/455 - (36%)	Gaps:	137/455 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TDFAMMPSVMLMQCAKIRVFKTDGLPSVICNNCI-----------YRLG--VAFHFKQECENSDL 76
            :|....|.|      |:.|.| .|:...|.|:.|           |..|  ...|::..||:.:
Human   109 SDLETRPKV------KLSVLK-QGISEEISNSVILVERFLWDGLWYCRGEDTEGHWEWSCESLE- 165

  Fly    77 RLRQYLG-------ILESWR-----QDAATNTDFVEKPLLPQRDSD------------------- 110
            .|...:.       :||.|:     ::.:.|.|...:|:.|:|.|.
Human   166 SLAVPVAFTPVKTPVLEQWQRNGFGENISLNPDLPHQPMTPERQSPHTWGTRGKREKPDLNVLQK 230

  Fly   111 ---EEEPV------------DAKVSKRRSRYQRKPPEEHK-----------------KRGPKP-- 141
               :|:|.            .|.:...|:....:|.|.|:                 ..|.||
Human   231 TCVKEKPYKCQECGKAFSHSSALIEHHRTHTGERPYECHECLKGFRNSSALTKHQRIHTGEKPYK 295

  Fly   142 ---------------------VPKMPHTCYECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFA 185
                                 ..:.|:.|.||.|||...:..:||.|||||||||:||.|.:.|.
Human   296 CTQCGRTFNQIAPLIQHQRTHTGEKPYECSECGKSFSFRSSFSQHERTHTGEKPYECSECGKAFR 360

  Fly   186 QKYNLKVHERTHTGDKPFQCEICSKQFSALGNFQAHQKIHLGVRDQVCSLCQKGFYTAGDLSKHM 250
            |..:|..|.|.|||:||:||..|.|.||...:...||:||.|.:...|..|.|.|.....|.:|.
Human   361 QSIHLTQHLRIHTGEKPYQCGECGKAFSHSSSLTKHQRIHTGEKPYECHECGKAFTQITPLIQHQ 425

  Fly   251 ITHTGIKNHHCDVCGKAFSRRRDMRTHKLKLHPLESSTNHDIVDDDDDEAIDTDPVGLDTLDHAH 315
            .||||.|.:.|..||||||:...:..|: ::|..|.                  |.|
Human   426 RTHTGEKPYECGECGKAFSQSTLLTEHR-RIHTGEK------------------PYG-------- 463

  Fly   316 FKCPDCDKAFDTADSLSLHFRTHAANNNLLNLPLPPAPPMSHHY-HHDALHHLGPPNPATQMGMA 379
              |.:|.|.|..:.|||.|.|||.............|...|.|. .|..:|....|......|.|
Human   464 --CNECGKTFSHSSSLSQHERTHTGEKPYECSQCGKAFRQSTHLTQHQRIHTGEKPYECNDCGKA 526

Fly 380 379
Human 527 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17328	NP_609786.2	zf-AD	8..80	CDD:214871	16/67 (24%)
		COG5048	146..>211	CDD:227381	34/64 (53%)
		C2H2 Zn finger	149..169	CDD:275368	9/19 (47%)
		C2H2 Zn finger	177..197	CDD:275368	8/19 (42%)
		zf-H2C2_2	189..213	CDD:404364	12/23 (52%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		zf-H2C2_2	245..270	CDD:404364	13/24 (54%)
		C2H2 Zn finger	261..282	CDD:275368	8/20 (40%)
		C2H2 Zn finger	318..338	CDD:275368	9/19 (47%)
ZNF135	NP_009065.1	KRAB	26..85	CDD:214630
		KRAB	26..65	CDD:279668
		zf-C2H2	238..260	CDD:278523	2/21 (10%)
		C2H2 Zn finger	240..260	CDD:275368	2/19 (11%)
		COG5048	264..665	CDD:227381	90/292 (31%)
		C2H2 Zn finger	268..288	CDD:275368	1/19 (5%)
		zf-H2C2_2	280..305	CDD:290200	3/24 (13%)
		C2H2 Zn finger	296..316	CDD:275368	0/19 (0%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		zf-H2C2_2	339..361	CDD:290200	15/21 (71%)
		C2H2 Zn finger	352..372	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..389	CDD:290200	13/24 (54%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		zf-H2C2_2	392..417	CDD:290200	9/24 (38%)
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		zf-H2C2_2	421..445	CDD:290200	13/23 (57%)
		C2H2 Zn finger	436..456	CDD:275368	8/20 (40%)
		C2H2 Zn finger	464..484	CDD:275368	9/19 (47%)
		zf-H2C2_2	476..501	CDD:290200	8/24 (33%)
		C2H2 Zn finger	492..512	CDD:275368	4/19 (21%)
		zf-H2C2_2	504..529	CDD:290200	6/23 (26%)
		C2H2 Zn finger	520..540	CDD:275368	2/7 (29%)
		zf-H2C2_2	532..557	CDD:290200
		C2H2 Zn finger	548..568	CDD:275368
		zf-H2C2_2	561..585	CDD:290200
		C2H2 Zn finger	576..596	CDD:275368
		C2H2 Zn finger	604..624	CDD:275368
		zf-H2C2_2	619..641	CDD:290200
		C2H2 Zn finger	632..652	CDD:275368
		zf-H2C2_2	644..669	CDD:290200
		C2H2 Zn finger	660..680	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000