DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17328 and PRDM15

DIOPT Version :9

Sequence 1:	NP_609786.2	Gene:	CG17328 / 34962	FlyBaseID:	FBgn0028895	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_011527985.1	Gene:	PRDM15 / 63977	HGNCID:	13999	Length:	1441	Species:	Homo sapiens

Alignment Length:	417	Identity:	108/417 - (25%)
Similarity:	154/417 - (36%)	Gaps:	106/417 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 ICNNCIYRLGVA-----FHFKQECENSDLRLRQYLGILESWRQDAATNTDFVEKPLLPQRDSDEE 112
            ||....:|:.|.     .|||......|.:..:::|.:....::...|:|          :|.:.
Human   867 ICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSEENDDNSD----------ESADS 921

  Fly   113 EPVDAKVSKRR--------SRYQRKPPEEHKKRG---------------------------PKP- 141
            ||  .|.|.:|        ..|.:...|.||::|                           |.|
Human   922 EP--HKYSCKRCQLTFGRGKEYLKHIMEVHKEKGYGCSICNRRFALKATYHAHMVIHRENLPDPN 984

  Fly   142 VPKMPHTCYECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFAQKYNLKVHERTHTGDKPFQCE 206
            |.|..|.|..|.:.|..|..|.:|...|||.|.:.|..|.:.||:|..||.|.|.|...:.:.|.
Human   985 VQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNVREYLCA 1049

  Fly   207 ICSKQFSALGNFQAHQKIHLGVRDQVCSLCQKGFYTAGDLSKHMITHTGIKNHHCDVCGKAFSRR 271
            .|.|........:.|.|:|.|:::..|..|.:.|....::.||...|||||:..|::|||.||.|
Human  1050 ECGKGMKTKHALRHHMKLHKGIKEYECKECHRRFAQKVNMLKHCKRHTGIKDFMCELCGKTFSER 1114

  Fly   272 RDMRTHKLKLHPLESSTNHDIVDDDDDEAIDTDPVGLDTLDHAHFKCPDCDKAFDTADSLSLHFR 336
            ..|.|||| :|                      .||      ..:.|..|||.:.|...|..|.:
Human  1115 NTMETHKL-IH----------------------TVG------KQWTCSVCDKKYVTEYMLQKHVQ 1150

  Fly   337 -TH----AANNNLLNLPLPPAPPMSHHYHH----------DALHHLGPPNPATQMGMAAMAHMLA 386
             ||    |.:..|....:.....||.|...          |.|.||    |.|....|:...::.
Human  1151 LTHDKVEAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLDHL----PETTTIDASSIGIVQ 1211

  Fly   387 PP-PPPPPTPSEGRYTMLHHTAAQRLH 412
            |. .......:||:    |..||:|.|
Human  1212 PELTLEQEDLAEGK----HGKAAKRSH 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17328	NP_609786.2	zf-AD	8..80	CDD:214871	8/31 (26%)
		COG5048	146..>211	CDD:227381	23/64 (36%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		C2H2 Zn finger	177..197	CDD:275368	9/19 (47%)
		zf-H2C2_2	189..213	CDD:404364	8/23 (35%)
		C2H2 Zn finger	205..225	CDD:275368	5/19 (26%)
		C2H2 Zn finger	233..253	CDD:275368	5/19 (26%)
		zf-H2C2_2	245..270	CDD:404364	12/24 (50%)
		C2H2 Zn finger	261..282	CDD:275368	12/20 (60%)
		C2H2 Zn finger	318..338	CDD:275368	7/20 (35%)
PRDM15	XP_011527985.1	SET	349..465	CDD:214614
		GAGA_bind	<515..>580	CDD:283799
		COG5048	663..1125	CDD:227381	77/292 (26%)
		zf-C2H2	672..694	CDD:278523
		C2H2 Zn finger	674..694	CDD:275368
		C2H2 Zn finger	701..722	CDD:275368
		C2H2 Zn finger	735..751	CDD:275368
		C2H2 Zn finger	789..809	CDD:275368
		C2H2 Zn finger	838..858	CDD:275368
		C2H2 Zn finger	865..885	CDD:275368	4/17 (24%)
		C2H2 Zn finger	928..949	CDD:275370	3/20 (15%)
		C2H2 Zn finger	956..976	CDD:275368	0/19 (0%)
		C2H2 Zn finger	992..1012	CDD:275368	6/19 (32%)
		zf-H2C2_2	1004..1029	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1020..1040	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1048..1068	CDD:275368	5/19 (26%)
		zf-H2C2_2	1060..1085	CDD:290200	7/24 (29%)
		C2H2 Zn finger	1076..1096	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1104..1124	CDD:275368	12/20 (60%)
		C2H2 Zn finger	1132..1153	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910