DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17328 and ZNF560

DIOPT Version :9

Sequence 1:	NP_609786.2	Gene:	CG17328 / 34962	FlyBaseID:	FBgn0028895	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_689689.2	Gene:	ZNF560 / 147741	HGNCID:	26484	Length:	790	Species:	Homo sapiens

Alignment Length:	337	Identity:	92/337 - (27%)
Similarity:	134/337 - (39%)	Gaps:	72/337 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GLPSVICNNCIYRLGVAFHFKQE-----------CENSDLRLRQYLGILESWRQDAATNT----- 96
            |:....|.:|.....|...|.:.           |:..........|::|..|..|...|
Human   372 GIKPYKCKHCGKTFTVPSGFLEHVRTHTGEKPYGCKECGKAFGTSAGLIEHIRCHAREKTFKCDH 436

  Fly    97 ---DFVEKPLL--PQRDSDEEEPVDAK------------VSKRRSRYQRKPPEEHKKRGPKPVPK 144
               .|:..|.|  ..|..:.|:|.:.|            :..|||...:|
Human   437 CGKAFISYPSLFGHLRVHNGEKPYEHKEYGKAFGTSSGVIEDRRSNTGQK--------------- 486

  Fly   145 MPHTCYECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFAQKYNLKVHERTHTGDKPFQCEICS 209
             ...|.:|.|.|...:.|..|:||||||||::|..|.:.|.....|::|.||||.::.:||:.|.
Human   487 -RFDCDQCGKVFVSFSSLFAHLRTHTGEKPFKCYKCGKPFTSSACLRIHMRTHTEERLYQCKKCG 550

  Fly   210 KQFSALGNFQAHQKIHLGVRDQVCSLCQKGFYTAGDLSKHMITHTGIKNHHCDVCGKAFSRRRDM 274
            |.|:.......|.:.|.|.:...|..|.|.|.....|:||:..|:|.|.:.|..|||||:.|.|:
Human   551 KAFTKCSYLTKHLRTHAGEKPYECMKCGKAFTERSYLTKHLRRHSGEKPYECKKCGKAFTERSDL 615

  Fly   275 RTHKLKLH----PLESSTNHDIVDDDDDEAIDTDPVGLDTLDHAH-------FKCPDCDKAFDTA 328
            ..| |:.|    |.|..        |..:|.   .|....:||..       :||..|:||:..:
Human   616 TKH-LRRHTGDKPYEYK--------DCGKAF---VVSSSLVDHLRTHTGYKPYKCNACEKAYSRS 668

  Fly   329 DSLSLHFRTHAA 340
            ..|:.|.:||||
Human   669 CVLTQHLKTHAA 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17328	NP_609786.2	zf-AD	8..80	CDD:214871	6/42 (14%)
		COG5048	146..>211	CDD:227381	26/64 (41%)
		C2H2 Zn finger	149..169	CDD:275368	7/19 (37%)
		C2H2 Zn finger	177..197	CDD:275368	6/19 (32%)
		zf-H2C2_2	189..213	CDD:404364	10/23 (43%)
		C2H2 Zn finger	205..225	CDD:275368	5/19 (26%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		zf-H2C2_2	245..270	CDD:404364	12/24 (50%)
		C2H2 Zn finger	261..282	CDD:275368	10/20 (50%)
		C2H2 Zn finger	318..338	CDD:275368	6/19 (32%)
ZNF560	NP_689689.2	KRAB	13..69	CDD:214630
		KRAB	13..50	CDD:279668
		KRAB	110..161	CDD:214630
		KRAB	110..149	CDD:279668
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	323..342	CDD:275368
		COG5048	344..754	CDD:227381	92/337 (27%)
		C2H2 Zn finger	350..370	CDD:275368
		zf-H2C2_2	362..386	CDD:290200	3/13 (23%)
		C2H2 Zn finger	378..398	CDD:275368	4/19 (21%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		C2H2 Zn finger	434..454	CDD:275368	4/19 (21%)
		C2H2 Zn finger	490..510	CDD:275368	7/19 (37%)
		zf-H2C2_2	502..527	CDD:290200	13/24 (54%)
		C2H2 Zn finger	518..538	CDD:275368	6/19 (32%)
		zf-H2C2_2	531..554	CDD:290200	10/22 (45%)
		C2H2 Zn finger	546..566	CDD:275368	5/19 (26%)
		zf-H2C2_2	558..582	CDD:290200	6/23 (26%)
		C2H2 Zn finger	574..594	CDD:275368	7/19 (37%)
		zf-H2C2_2	586..610	CDD:290200	11/23 (48%)
		zf-C2H2	600..622	CDD:278523	10/22 (45%)
		C2H2 Zn finger	602..622	CDD:275368	10/20 (50%)
		C2H2 Zn finger	630..650	CDD:275368	5/30 (17%)
		C2H2 Zn finger	658..678	CDD:275368	6/19 (32%)
		C2H2 Zn finger	714..734	CDD:275368
		zf-H2C2_2	726..751	CDD:290200
		C2H2 Zn finger	742..762	CDD:275368
		zf-H2C2_2	757..779	CDD:290200
		C2H2 Zn finger	770..790	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000