DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17328 and znf770

DIOPT Version :9

Sequence 1:	NP_609786.2	Gene:	CG17328 / 34962	FlyBaseID:	FBgn0028895	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_005160468.1	Gene:	znf770 / 100535231	ZFINID:	ZDB-GENE-030131-1505	Length:	1207	Species:	Danio rerio

Alignment Length:	334	Identity:	75/334 - (22%)
Similarity:	129/334 - (38%)	Gaps:	100/334 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 DAATNTDFVEK----------------PLL-PQRDSDEEEPVDAKVSKRRSRYQRKPPEEHKKRG 138
            |.:.|...|:|                ||: ...|:.:||.::.:::.....|.
Zfish   375 DVSQNLSTVDKQHLEMLQCDNHLNQNAPLINSSADTLKEEVIEEQIADANPTYF----------- 428

  Fly   139 PKPVPKMPHTCYECHKSFKCIAQLTQHIRTHTGEKPYQCSFCIQRFAQKYNLKVHERTH------ 197
             |...|..:.|..|.|.|...::|::|:..||.:||::||.|.:.|...|:|:.|::.|
Zfish   429 -KHTSKNVNQCKICLKKFSYPSRLSRHLLVHTDDKPFKCSECSKSFRNPYHLRRHQKIHKREKKY 492

  Fly   198 ----TG-----------------DKPFQCEICSKQFSALGNFQAHQKIHLGVRDQVCSLCQKGFY 241
                ||                 |..:||::|.|.||.....:.||.:|.|.:...|.:|:|.|.
Zfish   493 IANKTGHQLLYSSNVTSTSLLKTDSGYQCDVCLKTFSVPSKLRRHQIVHSGTKPYTCMICRKSFS 557

  Fly   242 TAGDLSKHMITHTG---------------------IKNHHC--------------DVCGKAFSRR 271
            .|..|:||:..|||                     ::.::|              .|.|:...:.
Zfish   558 QAYSLTKHIKLHTGKVNSPSLLHWLRGSKSSITGALQTNNCGPNDANASLPKELDSVDGQTNEKL 622

  Fly   272 RDMRTHKLKLHPLESST-----NHDIVDDDDDEAIDTDPVGLDTLDHAH--FKCPDCDKAFDTAD 329
            :|.......:...|||.     :.|::.|.::...::.|.  ::||.::  .:|..|.|.|....
Zfish   623 QDHSQLDQNVSLTESSNTVKTESEDVLKDSEEPTANSSPT--NSLDKSNDENQCVICLKTFPYPS 685

  Fly   330 SLSLHFRTH 338
            .||.|..||
Zfish   686 KLSRHLLTH 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17328	NP_609786.2	zf-AD	8..80	CDD:214871
		COG5048	146..>211	CDD:227381	24/91 (26%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		zf-H2C2_2	189..213	CDD:404364	10/50 (20%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		C2H2 Zn finger	233..253	CDD:275368	8/19 (42%)
		zf-H2C2_2	245..270	CDD:404364	9/59 (15%)
		C2H2 Zn finger	261..282	CDD:275368	4/34 (12%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
znf770	XP_005160468.1	C2H2 Zn finger	75..95	CDD:275368
		C2H2 Zn finger	103..123	CDD:275368
		C2H2 Zn finger	189..209	CDD:275368
		zf-H2C2_2	202..225	CDD:290200
		C2H2 Zn finger	217..257	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		C2H2 Zn finger	316..336	CDD:275368
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
		zf-C2H2	464..486	CDD:278523	7/21 (33%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		COG5048	497..902	CDD:227381	45/200 (23%)
		C2H2 Zn finger	521..541	CDD:275368	7/19 (37%)
		zf-H2C2_2	534..558	CDD:290200	8/23 (35%)
		C2H2 Zn finger	549..569	CDD:275368	8/19 (42%)
		C2H2 Zn finger	674..694	CDD:275368	7/19 (37%)
		C2H2 Zn finger	702..722	CDD:275368
		C2H2 Zn finger	740..760	CDD:275368
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	855..875	CDD:275368
		C2H2 Zn finger	883..903	CDD:275368
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1148..1168	CDD:275368
		zf-H2C2_2	1161..1185	CDD:290200
		C2H2 Zn finger	1176..1196	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930