Protein Alignment CG17329 and PJA2

DIOPT Version :10

• Sequence 1: NP_609784.2
• Gene: CG17329 / 34958
• FlyBaseID: FBgn0028896
• Length: 162
• Species: Drosophila melanogaster
• Sequence 2: NP_055634.3
• Gene: PJA2 / 9867
• HGNCID: 17481
• Length: 708
• Species: Homo sapiens
• Alignment Length: 189
• Identity: 43/189 - (22%)
• Similarity: 65/189 - (34%)
• Gaps: 65/189 - (34%)

  Fly     9 ERTEQQQQEPTEPS------------NGNLEEQVRKLRDHNL----------------RVKHLNT 45
            |..|....|..||:            |.|||:......|.::                .:.:::.
Human   507 EVNESSSDEGNEPANEFAQPAFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDP 571

  Fly    46 QRRRILRLLQGKMLQYATLEERLHRIGELVLIAELHS---GVKTLN-----QRLDRMVE------ 96
            |           .|.|..|||||.:..|..| |.|.|   .|:..|     :.:|.:.|
Human   572 Q-----------FLTYMALEERLAQAMETAL-AHLESLAVDVEVANPPASKESIDGLPETLVLED 624

  Fly    97 ------NSTCSICLLPWTDNGIHRLVSLRCGHLFGSSCIHMAIRRNHRCPICRRRARHF 149
                  ...|.||...:..:.|  ...|.|.|.|...|:.:.::::..||:||   |||
Human   625 HTAIGQEQCCPICCSEYIKDDI--ATELPCHHFFHKPCVSIWLQKSGTCPVCR---RHF 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17329	NP_609784.2	HRD1	<36..>144	CDD:227568	29/143 (20%)
		RING_Ubox	96..155	CDD:473075	17/66 (26%)
PJA2	NP_055634.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..90
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..317
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..495
		Interaction with PRKAR1A, PRKAR2A and PRKAR2B. /evidence=ECO:0000269|PubMed:21423175	531..708		38/165 (23%)
		Mediates interaction with TBC1D31. /evidence=ECO:0000269|PubMed:33934390	550..570		0/19 (0%)
		RING-H2_PJA1_2	633..678	CDD:438128	14/49 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..708