DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pkaap and akap10

DIOPT Version :9

Sequence 1:	NP_609783.1	Gene:	pkaap / 34957	FlyBaseID:	FBgn0040079	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_005165633.1	Gene:	akap10 / 566920	ZFINID:	ZDB-GENE-030131-2535	Length:	642	Species:	Danio rerio

Alignment Length:	593	Identity:	168/593 - (28%)
Similarity:	263/593 - (44%)	Gaps:	139/593 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 NDDIFTYNSRLSMNLASIVNDPNCLSYFVQYLDTRQALPLIKFYLDIENFK-------RA-ALTQ 155
            |..|....||||..:..|:.|...|.||:|:::||.|..|::|:|:.|:|:       || :|..
Zfish    91 NYQIQETRSRLSKTVDQILRDNVALPYFIQFMETRSAEHLVRFWLEAESFRSTSWSRVRAHSLNS 155

  Fly   156 EKEEPEEPPRKAIEQSSPHKDDKDVPELKTLCDLSMRKPLTDDE-----------KSRIYA---- 205
            .|......|..|:  .||  |..|.|...:       :||..||           .||.:.
Zfish   156 VKHSTLAEPAAAL--GSP--DSPDSPNHSS-------RPLNLDEGDEEDAFSSRTSSRPHTPSPQ 209

  Fly   206 ETNKQLNRQKSGTDSV---------------------------------------LNAELSRASI 231
            :||.......|..|||                                       |:.:|.::..
Zfish   210 DTNSHSGALMSHRDSVSFDGTAQPGTLQLQPALRSETPTRQTSSRTGTPVKGLRELSDKLMKSIE 274

  Fly   232 SDAIAIYQKYLIVNASLQVELPIVILAHISLLLCGRDKSECSKPIPASCFDEAREFVLEQLERDH 296
            .||:.|:.||:..:|:..:.:...|...|...:||.|..     :..:||..|:..|...:::.|
Zfish   275 RDAVNIFTKYISPDAARPIPITEQIRNDIVAKICGEDGQ-----VDPNCFVIAQSVVFSIIDQQH 334

  Fly   297 VQGFLQSGYYSTYCLELIEGGSVNIYDVLNSELALFYFTEYLEQRQERECLEFWITAINFRKSFA 361
            ...||:|.|:..|.:|::..|||.:.|:|..|.|||||:||:|:......|:||:.|.||:...|
Zfish   335 FTEFLRSHYFCKYQIEVLTSGSVFLADILFCESALFYFSEYMEKEDAMNVLQFWLAAENFQDQLA 399

  Fly   362 CGEEKEEDRKAAQSDAMIIYDKYFSLQSECRLWMSQKLRLRVEQAIC-----APNEQWQAFDLAL 421
             .::.:.|.:.||:||||:||||||||:...|.....:|:.:|..||     .|:    .|:..|
Zfish   400 -AKKGQYDGQEAQNDAMILYDKYFSLQATNPLGFGDSVRMEIESNICREGGPLPD----CFNTPL 459

  Fly   422 LVTAKYLEQKYFADFLKSHIFDNYVNEL--KVKRD-----NSTTHPNLQHTLSLRRAGKSSNGQQ 479
            ......:|:.|...||.|:::..|:::|  .|:.|     |:.| ||              .|..
Zfish   460 RQAWTTMEKVYMPGFLSSNLYYKYLSDLINSVRVDEFIGGNANT-PN--------------QGWT 509

  Fly   480 QRHRKTLSMSDCTHIS-QHNT------LLASMDQAPSKTALNHQSGNLNIDARQLTNPQLLWQRP 537
            |...:..|:::.:|:. |..|      :|.:.|:|            :.:|...| :|:.|:|||
Zfish   510 QEGERNSSVTEGSHVQLQQGTKKAAIKILKNFDEA------------ITVDIASL-DPESLYQRP 561

  Fly   538 -VGALKFGFVNSLGRYERDFEAVDAVALKSQPWSLSVSGSKLKNAMRKLVNLPEDNVQEEIAWQV 601
             .|.:.||.||.||::.|:.|        .:|......||....||:|.|....|..|||:||::
Zfish   562 YAGRMTFGKVNELGQFIREAE--------PEPDVKKSKGSMFSLAMKKWVQGNSDEAQEEMAWKI 618

  Fly   602 AEMIVRDV 609
            |:|||.||
Zfish   619 AKMIVNDV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pkaap	NP_609783.1	RGS	109..308	CDD:295367	61/260 (23%)
		RGS_AKAP2_2	324..444	CDD:188676	45/124 (36%)
		AKAP10_AKB	561..605	CDD:214003	14/43 (33%)
akap10	XP_005165633.1	RGS_AKAP2_1	101..346	CDD:188689	61/260 (23%)
		RGS_AKAP2_2	362..482	CDD:188676	45/124 (36%)
		AKAP10_AKB	598..642	CDD:214003	16/29 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579742
Domainoid	1	1.000	82	1.000	Domainoid score	I8377
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32452
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3900
OMA	1	1.010	-	-		QHG45560
OrthoDB	1	1.010	-	-		D288202at33208
OrthoFinder	1	1.000	-	-		FOG0006831
OrthoInspector	1	1.000	-	-		oto40943
orthoMCL	1	0.900	-	-		OOG6_107972
Panther	1	1.100	-	-	LDO	PTHR13155
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3006
SonicParanoid	1	1.000	-	-		X4922
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940