DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crp and tfap4

DIOPT Version :9

Sequence 1:	NP_001285976.1	Gene:	crp / 34956	FlyBaseID:	FBgn0001994	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_001123841.1	Gene:	tfap4 / 100170601	XenbaseID:	XB-GENE-999265	Length:	333	Species:	Xenopus tropicalis

Alignment Length:	407	Identity:	121/407 - (29%)
Similarity:	177/407 - (43%)	Gaps:	159/407 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 DSEKRMRREIANSNERRRMQSINAGFQSLRSLLPRHEGEKLSKAAILQQTFQYIVELENQKTQLL 155
            |.|:|:|||||||||||||||||||||||::|:|..:|||||||||||||.:||..||.:||:||
Frog    43 DQERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLL 107

  Fly   156 TQNSELKRQVGEHEAGGSGDGGGTNSGGNYNDSNASGGNSTAVAIKKRKLTDNVINIQAISDSSD 220
            .||::|||.:.|                 :|.|:.          |:|:..|           .|
Frog   108 QQNTQLKRFIQE-----------------FNGSSP----------KRRRAED-----------KD 134

  Fly   221 EGLGSMSPEPMTLLTAGGAAATKLSNAATLLAAKELHESKKQLEKERSLRRLLEDELQMIKRQLY 285
            ||:|  ||:           ..:...|..|  .:|:.|.::||:||||:|.:||::::.::..:|
Frog   135 EGIG--SPD-----------IWEEEKADDL--RREMIELRQQLDKERSVRMMLEEQVRALEAHMY 184

  Fly   286 SVATAPPGTAVAAASGGSSGAYIPREVIEHTDNFVRSEDLEELGGTVSYVEIDEMTGQQQVVVCS 350
                                   |.::........:.||    ||..|        |:|
Frog   185 -----------------------PEKLKALAQQIQQQED----GGQAS--------GEQ------ 208

  Fly   351 SIEELEADAAAEIITEDQVHEEVILSSNSSTESENEVNVNAIAKAYAEGCTSSAAMLQPILQAAI 415
             ::.::.:       |..:|.:                                 :|.|.|..|.
Frog   209 -LQNIDRE-------EQHLHSQ---------------------------------LLPPHLPLAP 232

  Fly   416 KATPKVEVER----IHEKIVKVKTEKHD--LPSMQTAPHYQHSHRQNLETIVQAIRHLEGDHLFA 474
            ...|.|.|..    .|.  |.|.|..|.  :.|:.|:       ||||:||||||:|:||.
Frog   233 THHPTVIVPAPPPPSHH--VNVVTMGHSSVISSVSTS-------RQNLDTIVQAIQHIEGT---- 284

  Fly   475 DGSGGQEKFGQQQNLQQ 491
                 :||..|::.|::
Frog   285 -----REKQLQEEELRR 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crp	NP_001285976.1	HLH	97..148	CDD:278439	40/50 (80%)
tfap4	NP_001123841.1	PTZ00121	<39..217	CDD:173412	88/275 (32%)
tfap4	NP_001123841.1	bHLHzip_TFAP4	46..106	CDD:381425	45/59 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8352
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4261
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1565841at2759
OrthoFinder	1	1.000	-	-		FOG0006895
OrthoInspector	1	1.000	-	-		oto104885
Panther	1	1.100	-	-	LDO	PTHR15741
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5304
SonicParanoid	1	1.000	-	-		X5799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100