DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twe and CDC25A

DIOPT Version :9

Sequence 1:	NP_001260491.1	Gene:	twe / 34954	FlyBaseID:	FBgn0002673	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001780.2	Gene:	CDC25A / 993	HGNCID:	1725	Length:	524	Species:	Homo sapiens

Alignment Length:	444	Identity:	133/444 - (29%)
Similarity:	201/444 - (45%)	Gaps:	105/444 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DPHDADMEYQAKRRKSAVQETPLQWMLKRHIPASTTVLSPITELSQNMNGARLDGTPKSTQRIPA 90
            || |.:.|.:|...|..|:                    |::....:.:|.: :|....|||
Human   136 DP-DENKENEAFEFKKPVR--------------------PVSRGCLHSHGLQ-EGKDLFTQR--- 175

  Fly    91 NRTLNNFNSLSSRTLGSFSSSCSSYESGNSL----------------DDEYMDMFEMESAENHNL 139
                  .||..:|.|.  |:...|.|.||.:                ||.::|:.:.|:.:|..
Human   176 ------QNSAPARMLS--SNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEE- 231

  Fly   140 ELPDDLEVLLSGQL-KSESNLEEMSNKKGSLRRCLSMYPS--EQPEEAVQE-------------- 187
            |.|..:..|.:..| ...:||:.......|...|.|...|  ::||.:.:|
Human   232 ETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSG 296

  Fly   188 --PDQETNMPMKKMQ--RKTLSMNDA---EIMRALGDEP-ELIGDLSKPCTLPCLATGIRHRDLK 244
              |.:.|| |.|..:  .::||:..:   .|...|.::| :||||.||......:|.  :|:|||
Human   297 ASPKESTN-PEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAG--KHQDLK 358

  Fly   245 TISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAF--PTLTSN 307
            .||.:.:|.::.|:|...:..   :.|||||||||:.||||:||.||:...::::..  ..:...
Human   359 YISPEIMASVLNGKFANLIKE---FVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPT 420

  Fly   308 QENRRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQP 372
            ...|.|.||||||||||||::.||:|..||.  .:.||.|.|||||:|..||||||......|:|
Human   421 DGKRVIVVFHCEFSSERGPRMCRYVRERDRL--GNEYPKLHYPELYVLKGGYKEFFMKCQSYCEP 483

  Fly   373 SQYVPMLAPAHNDEF----RYFRAKTKSWQCGEGGDSGIGGGGSRGLRKSRSRL 422
            ..|.||    |:::|    :.||.|:::|            .|.:..|:..|||
Human   484 PSYRPM----HHEDFKEDLKKFRTKSRTW------------AGEKSKREMYSRL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twe	NP_001260491.1	Cdc25	243..363	CDD:238788	56/121 (46%)
CDC25A	NP_001780.2	Phosphodegron	74..84
		M-inducer_phosp	86..328	CDD:310900	48/226 (21%)
		KEN box	141..143		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..317		11/53 (21%)
		Cdc25	357..475	CDD:238788	57/122 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148391
Domainoid	1	1.000	114	1.000	Domainoid score	I6064
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3749
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1423329at2759
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		mtm8627
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	O	PTHR10828
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R583
SonicParanoid	1	1.000	-	-		X695
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790