Protein Alignment twe and cdc25b

DIOPT Version :9

• Sequence 1: NP_001260491.1
• Gene: twe / 34954
• FlyBaseID: FBgn0002673
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001108567.1
• Gene: cdc25b / 57925
• ZFINID: ZDB-GENE-000330-5
• Length: 563
• Species: Danio rerio
• Alignment Length: 540
• Identity: 141/540 - (26%)
• Similarity: 210/540 - (38%)
• Gaps: 202/540 - (37%)

  Fly    57 PASTTVLSPITELSQNMNGARLDG----TPKSTQRIP---------------------------- 89
            |....||||:|.|:.|||...:.|    |||..:.:|
Zfish    49 PGPMAVLSPVTNLALNMNNLAVLGGQCETPKRKKNLPLLKIPSFASDASSDAGLGLECPSPLDSL 113

  Fly    90 ------------ANRTLN------NFNSLSSRTLG--------------------SFSSS----- 111
                        |.|.:|      ..:||..:.||                    |..|:
Zfish   114 DAEQKFEKAMQDATRAVNEKMPIRRIHSLPLQFLGHSPNLRSKELDPSRYGVWTHSHDSANKENM 178

  Fly   112 ----------------CSSYESGNS---------------------------------------- 120
                            |.:..:|.|
Zfish   179 AEENFEFKKPSMPALRCRTRSTGGSKDAFACRPNSAPALMLSPPPTNQPDSPNEISPFILRRPSL 243

  Fly   121 ---LDDEYMDMF--EMESAENHNLELPDDLEVLLSGQLKSESNLEEMS-----NKKGSLRR---- 171
               .||:..|.|  .::..||.: |:|..::.||:..|.::...|..|     ..:|..|.
Zfish   244 SCLQDDDDDDGFLEGLDDVENDS-EVPLGMDSLLTAPLVAKQIPETDSPVIRCRPRGLFRSPSMP 307

  Fly   172 -CLSMYPSEQPEEAVQEPDQETNMPMKKMQRKTL---------------------SMNDAEIMRA 214
             .:...|.::||.     .|:.|.|::..:|::|                     |.|.::|.|.
Zfish   308 CAVGRIPLKRPER-----PQDENTPVRVKRRRSLAGTQVSTTEQEDVVHQVQRSKSFNHSQIERM 367

  Fly   215 LGDEP-ELIGDLSKPCTLPCLATGIRHRDLKTISSDTLARLIQGEFD---EQLGSQGGYEIIDCR 275
            |..:| .:|||.:|...||.:..  :|::||.|:.:.:.:.:.|:|.   |:|      .:||||
Zfish   368 LDTDPSNVIGDFTKAPALPTVQG--KHQELKYITPEIMVKAMSGQFQDLVERL------FVIDCR 424

  Fly   276 YPYEFLGGHIRGAKNLYTRGQIQEAF---PTLTSNQENRRIYVFHCEFSSERGPKLLRYLRSNDR 337
            ||||:.||||:||.||:...||::.|   |.|....:.|.:.:|||||||||||::.||:|..||
Zfish   425 YPYEYEGGHIKGALNLHQEDQIEDYFLRSPILPDCPKKRVLLIFHCEFSSERGPRMCRYVRERDR 489

  Fly   338 SQHTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLAPAHNDEFRYFRAKTKSWQCGEG 402
              ..:.||.|.|||||||..||||||.::..:|:|..|.|||.....::.|.||.|:::|
Zfish   490 --FVNEYPNLHYPELYILKGGYKEFFQIHKAICEPQMYRPMLHEEFKEDLRKFRLKSRTW----- 547

  Fly   403 GDSGIGGGGSRGLRKSRSRL 422
                   .|.|..|...|||
Zfish   548 -------AGERSKRDMYSRL 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twe	NP_001260491.1	Cdc25	243..363	CDD:238788	59/125 (47%)
cdc25b	NP_001108567.1	M-inducer_phosp	104..366	CDD:284119	38/267 (14%)
		Cdc25	395..514	CDD:238788	60/126 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586493
Domainoid	1	1.000	116	1.000	Domainoid score	I5911
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3648
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1423329at2759
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		otm25431
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	O	PTHR10828
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R583
SonicParanoid	1	1.000	-	-		X695
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790