DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twe and cdc25d

DIOPT Version :9

Sequence 1:	NP_001260491.1	Gene:	twe / 34954	FlyBaseID:	FBgn0002673	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	XP_017210413.1	Gene:	cdc25d / 558053	ZFINID:	ZDB-GENE-090313-74	Length:	388	Species:	Danio rerio

Alignment Length:	384	Identity:	127/384 - (33%)
Similarity:	181/384 - (47%)	Gaps:	75/384 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SPITELSQNMNGARL-DG-TPK-STQR---IPANRTLNNFNSLS-------------SRTLGSFS 109
            ||:.|||..:...:. || :|| ||.|   :......::.|:||             ||:|...|
Zfish    17 SPVNELSFRLQNLQCQDGLSPKRSTPRKLVLTPECMSSSLNTLSREKETPTVRRRRASRSLSPES 81

  Fly   110 SS----CSSYESGNSLDDEYMDMFEMESAENHNLELPDDLEVLLSGQLKSESNLEEMSNKKGSLR 170
            :|    |   ...|:.|         ..|...|......|.|.||.:. |.||..|.:   |..|
Zfish    82 TSNTPRC---PLRNNQD---------FPANKENERAIKRLRVRLSSRF-SSSNATETA---GRNR 130

  Fly   171 RCLSMYPSEQPEEAVQEPDQETNMPMKKMQ-RKTLSMNDA---EIMRALGDEPELIGDLSKPCTL 231
            |   .|.|:..|:|....:.|...||..:: |:.:|...|   .:.:....:..||||.||...|
Zfish   131 R---QYRSDPEEDATPSRETEAVDPMAAVRFRQLMSQLQAPPTPVTQVAVADLTLIGDFSKQHLL 192

  Fly   232 PCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQ 296
            |..:.|  |::...||:.|:|.||:|:|...:..   :.|:|||||||:.||||:||.||||..|
Zfish   193 PVESAG--HQEHHCISAQTVASLIRGQFGSAVED---FLIVDCRYPYEYQGGHIKGAVNLYTEHQ 252

  Fly   297 IQE--------------------AFPTLTSNQE--NRRIYVFHCEFSSERGPKLLRYLRSNDRSQ 339
            :|:                    |..:|..::|  :|::.:|||||||||||.|.:|||..||..
Zfish   253 VQQVLHQASAQVSVSTSRLCGRSASDSLPEDEESPSRKLIIFHCEFSSERGPHLCQYLRRLDRCV 317

  Fly   340 HTHNYPALDYPELYILHNGYKEFFGLYSQLCQPSQYVPMLAPAHNDEFRYFRAKTKSWQ 398
            :.  ||:|.|||||:|..|||.|...|..||.|..||.|....:.::...|..:.::.|
Zfish   318 NV--YPSLHYPELYLLLGGYKHFHASYPDLCDPCGYVSMRQREYREQLNSFLRRRQTRQ 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twe	NP_001260491.1	Cdc25	243..363	CDD:238788	61/141 (43%)
cdc25d	XP_017210413.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5911
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1423329at2759
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R583
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.810