DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment twe and cdc25

DIOPT Version :9

Sequence 1:	NP_001260491.1	Gene:	twe / 34954	FlyBaseID:	FBgn0002673	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001342797.1	Gene:	cdc25 / 2542632	PomBaseID:	SPAC24H6.05	Length:	596	Species:	Schizosaccharomyces pombe

Alignment Length:	504	Identity:	125/504 - (24%)
Similarity:	192/504 - (38%)	Gaps:	167/504 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RRKSAVQETPLQWMLKRHIPASTTVLSPITELSQN-------------------MNGARLDGT-- 81
            |..|...||||         |:.|::||:.|...|                   .:..|:..|
pombe    96 RSLSCTVETPL---------ANKTIVSPLPESPSNDALTESYFFRQPASKYSITQDSPRVSSTIA 151

  Fly    82 ----PKSTQRIPANRTLNNFNSLSSRTLGSF-------------------SSSCSSY-------- 115
                ||::..:...::....:||||.:..|:                   |.|.|||
pombe   152 YSFKPKASIALNTTKSEATRSSLSSSSFDSYLRPNVSRSRSSGNAPPFLRSRSSSSYSINKKKGT 216

  Fly   116 ------------------ESGNS-------LDDEYMDMFEMESAENHNL------ELPDDLEVLL 149
                              :|.|:       |.|: .|.||:.|......      :||:....|:
pombe   217 SGGQATRHLTYALSRTCSQSSNTTSLLESCLTDD-TDDFELMSDHEDTFTMGKVADLPESSVELV 280

  Fly   150 SGQLK-----------SESNLEEMSNKKGSLRRCLSMYP--------------SEQPEEAVQEPD 189
            .....           ::::|:::.  :.|..:.:.|.|              |..|.....:.|
pombe   281 EDAASIQRPNSDFGACNDNSLDDLF--QASPIKPIDMLPKINKDIAFPSLKVRSPSPMAFAMQED 343

  Fly   190 QETNMPMKKMQRKTLSM--NDAEI-------------MRALGDEPELIGDLSKPCTLPCLATGIR 239
            .|.:.....:.|:|.||  |...:             .::..:....|....:..:|||.|  ::
pombe   344 AEYDEQDTPVLRRTQSMFLNSTRLGLFKSQDLVCVTPKQSTKESERFISSHVEDLSLPCFA--VK 406

  Fly   240 HRDLKTISSDTLARLIQGE----FDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEA 300
            ...||.|:.:||..|:.|:    ||:.:       |||||:.||:|||||..|.||.|:..|.:|
pombe   407 EDSLKRITQETLLGLLDGKFKDIFDKCI-------IIDCRFEYEYLGGHISTAVNLNTKQAIVDA 464

  Fly   301 FPTLTSNQENRRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGL 365
            |  |:....:|...|||||.|:.|.|.|..:.|:.||..::|.||.|.|||:||||.|||.|:..
pombe   465 F--LSKPLTHRVALVFHCEHSAHRAPHLALHFRNTDRRMNSHRYPFLYYPEVYILHGGYKSFYEN 527

  Fly   366 YSQLCQPSQYVPMLAPAH-------------NDEFRYFRAKTKSWQCGE 401
            :...|.|..||||...:|             |..|    .:|||:..|:
pombe   528 HKNRCDPINYVPMNDASHVMTCTKAMNNFKRNATF----MRTKSYTFGQ 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twe	NP_001260491.1	Cdc25	243..363	CDD:238788	56/123 (46%)
cdc25	NP_001342797.1	MIH1	108..596	CDD:227436	118/483 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I1870
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		otm47269
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	O	PTHR10828
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R583
SonicParanoid	1	1.000	-	-		X695
TreeFam	1	0.960	-	-
	10	9.800