DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment twe and Cdc25b

DIOPT Version :9

Sequence 1:	NP_001260491.1	Gene:	twe / 34954	FlyBaseID:	FBgn0002673	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_598256.2	Gene:	Cdc25b / 171103	RGDID:	621500	Length:	575	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	151/509 - (29%)
Similarity:	217/509 - (42%)	Gaps:	138/509 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EDDESGAC--GQENFDPHDADMEY-QAKRRKSAVQETPLQWMLKR----------HIPASTTVLS 64
            |..::|.|  .....||..|:..: ||.:..|.|.:.. |:.:||          |.|    ||.
  Rat   103 ESSDAGLCMDSPSPMDPQTAERTFEQAIQAASRVIQNE-QFTIKRFRSLPVRLLGHSP----VLQ 162

  Fly    65 PITELSQNMN-------GARLDGTP-----------KSTQRIPANRTLNNFNSLSSRTLGSF--- 108
            .||. ||.::       |.|...:|           |..|::|        :|.|:|.|..:
  Rat   163 NITN-SQALDSWEKDEAGYRAASSPGEDKENDGYIFKMPQKLP--------HSSSARALAEWASR 218

  Fly   109 ---------------------------------SSSCSSYESGNSLDDEYMDMFEMESAENHNLE 140
                                             |||.:..|.....||.::|:.|.:..::.  .
  Rat   219 REAFTQRPSSAPDLMCLTTDGKMDVEEASPVAQSSSLTPVERACEEDDGFVDILESDLKDDD--M 281

  Fly   141 LPDDLEVLLSGQLKSESNLEE-----MSNKKGSLRRCLSMYPS---------EQPEE---AVQEP 188
            :|..:|.|:|..|..:.:.||     |.:|...|.|..||..|         |:|.:   .|...
  Rat   282 VPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLERPHDRDVPVLSK 346

  Fly   189 DQETNMPMKKMQRKTLSMNDAEIMRAL-----------GDEPELIGDLSKPCTLPCLATGIRHRD 242
            .:::..|:::.|   |....|.:.|:.           .|...||||.||...|..:..  :|:|
  Rat   347 RRKSGTPLEEQQ---LEEPKARVFRSKSLCHEIESILDSDHRGLIGDYSKAFLLQTVDG--KHQD 406

  Fly   243 LKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAF----PT 303
            ||.||.:|:..|:.|:|...:..   :.|:|||||||:.||||:.|.||..... .|.|    |.
  Rat   407 LKYISPETMVALLTGKFSNIVEK---FVIVDCRYPYEYEGGHIKNAVNLPLEPD-AETFLLKHPI 467

  Fly   304 LTSNQENRRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQ 368
            ...|.:.|.|.:|||||||||||::.|::|..||:  .::||:|.|||:|||..||||||..:..
  Rat   468 TPCNLDKRIILIFHCEFSSERGPRMCRFIRERDRA--ANDYPSLYYPEMYILKGGYKEFFPQHPN 530

  Fly   369 LCQPSQYVPMLAPAHNDEFRYFRAKTKSWQCGEGGDSGIGGGGSRGLRKSRSRL 422
            .|:|..|.||...|..||.|.||.||:||            .|.|..|:..|||
  Rat   531 FCEPQDYRPMNHAAFRDELRNFRLKTRSW------------AGERSRRELCSRL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twe	NP_001260491.1	Cdc25	243..363	CDD:238788	57/123 (46%)
Cdc25b	NP_598256.2	M-inducer_phosp	111..378	CDD:399542	58/285 (20%)
Cdc25b	NP_598256.2	Cdc25	407..526	CDD:238788	58/124 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I5909
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3762
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1423329at2759
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		mtm9106
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	O	PTHR10828
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X695
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870