DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twe and Cdc25a

DIOPT Version :9

Sequence 1:	NP_001260491.1	Gene:	twe / 34954	FlyBaseID:	FBgn0002673	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_598255.2	Gene:	Cdc25a / 171102	RGDID:	621498	Length:	525	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	120/383 - (31%)
Similarity:	180/383 - (46%)	Gaps:	95/383 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NSLSSRTLGSFSSSCSSYESGN----------------SLDDEYMDMFEMESAENHNLELPDDLE 146
            ||..:|.|.|..|..|  ||||                ..||.::|:.:.|:.:|.. |.|..:.
  Rat   177 NSAPARMLSSNESDIS--ESGNFSPLFTPQSPVKATLSDEDDGFIDLLDGENLKNDE-ETPSCMS 238

  Fly   147 VLLSGQL--KSESNLEEMSNKKGSLRRCLSMYPSEQP--------EEAVQEPDQETN-------- 193
            .|.:..|  :..:||.:         || .::.|..|        ..||:..|:...
  Rat   239 SLWTAPLVMRRPTNLAD---------RC-GLFDSPSPCSSTSSCSTRAVKRADRSHEESPRGTKR 293

  Fly   194 ------MPMK-------KMQRKTLSMND---AEIMRALGDEP-ELIGDLSKPCTLPCLATGIRHR 241
                  .|:|       ::..::||:..   ..|...|..:| :||||.||......::.  :|:
  Rat   294 RKSSEASPVKADVPEPTQLPHQSLSLTSFPKGTIENILDSDPRDLIGDFSKGYLFHTVSG--KHQ 356

  Fly   242 DLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAF---PT 303
            |||.||.:.:|.::.|:|...:..   :.|||||||||:.||||:||.||:...:::|..   |.
  Rat   357 DLKYISPEIMASVLNGKFANLIKE---FVIIDCRYPYEYEGGHIKGAVNLHMEEEVEEFLLKKPI 418

  Fly   304 LTSNQENRRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQ 368
            :.::.: |.|.||||||||||||::.||:|..||.  .:.||.|.|||||:|..||||||.....
  Rat   419 VPADGK-RVIVVFHCEFSSERGPRMCRYVRERDRL--GNEYPKLHYPELYVLKGGYKEFFLKCQS 480

  Fly   369 LCQPSQYVPMLAPAHNDEF----RYFRAKTKSWQCGEGGDSGIGGGGSRGLRKSRSRL 422
            .|:|..|.||    |:::|    :.||.|:::|            .|.:..|:..|||
  Rat   481 HCEPPSYRPM----HHEDFKEDLKKFRTKSRTW------------AGEKSKREMYSRL 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twe	NP_001260491.1	Cdc25	243..363	CDD:238788	58/122 (48%)
Cdc25a	NP_598255.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Phosphodegron	74..84
		M-inducer_phosp	86..329	CDD:399542	34/164 (21%)
		KEN box	141..143
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..318		7/57 (12%)
		Cdc25	358..475	CDD:238788	58/122 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342301
Domainoid	1	1.000	114	1.000	Domainoid score	I5909
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3762
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1423329at2759
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		mtm9106
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	O	PTHR10828
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X695
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760