DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment twe and Cdc25b

DIOPT Version :9

Sequence 1:	NP_001260491.1	Gene:	twe / 34954	FlyBaseID:	FBgn0002673	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_075606.1	Gene:	Cdc25b / 12531	MGIID:	99701	Length:	576	Species:	Mus musculus

Alignment Length:	509	Identity:	146/509 - (28%)
Similarity:	218/509 - (42%)	Gaps:	137/509 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EDDESGAC--GQENFDPHDADMEY-QAKRRKSAVQETPLQWMLK--RHIPASTTVLSPITELSQN 72
            |..::|.|  .....||..|:..: ||.:..|.|.:.. |:.:|  |.:|......||:  |...
Mouse   103 ESSDAGLCMDSPSPVDPQMAERTFEQAIQAASRVIQNE-QFTIKRFRSLPVRLLEHSPV--LQSI 164

  Fly    73 MNGARLD-------------GTP-----------KSTQRIPANRTLNNFNSLSSRTLGSF----- 108
            .|...||             .:|           |..|.:|        :|.|::.|..:
Mouse   165 TNSRALDSWRKTEAGYRAAANSPGEDKENDGYIFKMPQELP--------HSSSAQALAEWVSRRQ 221

  Fly   109 -------------------------------SSSCSSYESGNSLDDEYMDMFEMESAENHNLELP 142
                                           |||.:..|..:..||.::|:.|.:..::.  ::|
Mouse   222 AFTQRPSSAPDLMCLTTEWKMEVEELSPVAQSSSLTPVERASEEDDGFVDILESDLKDDE--KVP 284

  Fly   143 DDLEVLLSGQLKSESNLEE-----MSNKKGSLRRCLSMYPSEQPEEAVQ------EPDQETNMPM 196
            ..:|.|:|..|..:.:.||     |.:|...|.|..||     |...::      |..|:.::|:
Mouse   285 AGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSM-----PCSVIRPILKRLERPQDRDVPV 344

  Fly   197 KKMQRKT--------LSMNDAEIMRAL-----------GDEPELIGDLSKPCTLPCLATGIRHRD 242
            :..:||:        |....|.:.|:.           .|...||||.||...|..:..  :|:|
Mouse   345 QSKRRKSVTPLEEQQLEEPKARVFRSKSLCHEIENILDSDHRGLIGDYSKAFLLQTVDG--KHQD 407

  Fly   243 LKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAF----PT 303
            ||.||.:|:..|:.|:|...:..   :.|:|||||||:.||||:.|.||... :..|.|    |.
Mouse   408 LKYISPETMVALLTGKFSNIVEK---FVIVDCRYPYEYEGGHIKNAVNLPLE-RDAETFLLQRPI 468

  Fly   304 LTSNQENRRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNYPALDYPELYILHNGYKEFFGLYSQ 368
            :..:.:.|.|.:|||||||||||::.|::|..||:  .::||:|.|||:|||..||||||..:..
Mouse   469 MPCSLDKRIILIFHCEFSSERGPRMCRFIRERDRA--ANDYPSLYYPEMYILKGGYKEFFPQHPN 531

  Fly   369 LCQPSQYVPMLAPAHNDEFRYFRAKTKSWQCGEGGDSGIGGGGSRGLRKSRSRL 422
            .|:|..|.||...|..||.|.||.||:||            .|.|..|:..|||
Mouse   532 FCEPQDYRPMNHEAFRDELRNFRLKTRSW------------AGERSRRELCSRL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twe	NP_001260491.1	Cdc25	243..363	CDD:238788	56/123 (46%)
Cdc25b	NP_075606.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..119		3/15 (20%)
		M-inducer_phosp	111..379	CDD:284119	54/285 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..358		4/19 (21%)
		Cdc25	408..527	CDD:238788	57/124 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6050
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3772
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		mtm8860
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	O	PTHR10828
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R583
SonicParanoid	1	1.000	-	-		X695
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850