DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoGI and Xrcc5

DIOPT Version :9

Sequence 1:	NP_001260489.1	Gene:	EndoGI / 34953	FlyBaseID:	FBgn0028515	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	XP_038939801.1	Gene:	Xrcc5 / 363247	RGDID:	3976	Length:	744	Species:	Rattus norvegicus

Alignment Length:	324	Identity:	63/324 - (19%)
Similarity:	113/324 - (34%)	Gaps:	117/324 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VKDYQKLIETRVQ---VDEIVDD-DVTKENFDRTAAAARDVIWRLLFDEAGTSQSNTEKASQLLE 93
            :|:.:|...|..|   :|:::|. .:.|:|.:      .|:| ..||..:.......::..|.|
  Rat   438 LKNNKKCTPTEAQLSAIDDLIDSMSLVKKNEE------EDII-EDLFPTSKIPNPEFQRLYQCL- 494

  Fly    94 EYRGDACFYDPTPYNEWIVKLRDEVLKKELLDFWRDVLVKKQLGPCWSRDSDLFDSDDTPPLEFY 158
                                            ..|.:.::::|.|......::.|    ||.|.
  Rat   495 --------------------------------LHRALHLQERLPPIQQHILNMLD----PPTEM- 522

  Fly   159 AHAGCTAPFAASLKVRAAL--------EEQASLD-------QDGPA-----TPTTPGELSADDAA 203
             .|.|..|.:   ||:...        ::|.:..       ::|||     |....|.:|....|
  Rat   523 -KAKCEIPLS---KVKTLFPLTEVVKKKDQVTAQDVFQDNIEEGPAAKKYKTEKEEGHISISSLA 583

  Fly   204 ALSGEFEATLTK---ENPLEEYRTLMKRFVLTKIIVPDSVHQASVKKIAAAAREI-----IWKLL 260
                  |..:||   .||:|.:|.|::                  :|||:...|:     .|:||
  Rat   584 ------EGNVTKVGSVNPVENFRVLVR------------------QKIASFEEELGTEPRAWRLL 624

  Fly   261 -----------FDGTPSAEDQNKAAELLQEYKGDA-GFYGPDDYNSWIFNLRDEVLTKELLDFW 312
                       |..|.......|:.:.::..:.:| .|.....:||::..||::|..|:|..||
  Rat   625 ASLQLMSHIEQFLDTNETLYFMKSMDCIKALREEAIQFSEEQRFNSFLEGLREKVEIKQLNHFW 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoGI	NP_001260489.1	Ku_PK_bind	31..138	CDD:285938	16/108 (15%)
Xrcc5	XP_038939801.1	Ku_N	9..244	CDD:397685
		KU80	246..542	CDD:238445	26/152 (17%)
		Ku_PK_bind	594..719	CDD:400921	26/113 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003754
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930