Protein Alignment EndoGI and XRCC6

DIOPT Version :9

• Sequence 1: NP_001260489.1
• Gene: EndoGI / 34953
• FlyBaseID: FBgn0028515
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_001275905.1
• Gene: XRCC6 / 2547
• HGNCID: 4055
• Length: 609
• Species: Homo sapiens
• Alignment Length: 347
• Identity: 67/347 - (19%)
• Similarity: 116/347 - (33%)
• Gaps: 108/347 - (31%)

  Fly     1 MSKRKAEDTQSDKMATAEKVAQNDYTI-----GLVD------PVKDYQKLIETRVQVDEIVDDDV 54
            :.|.:|::|:...::..:.....|..|     .||.      |:|.|:   ||...|.
Human   243 LRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYR---ETNEPVK------- 297

  Fly    55 TKENFDRTAAAARDVIWRLLFDEAGTSQSNTEKASQLL---EEYRGDACFYDP----TPYNEWIV 112
            ||.....|:...       |...:.|.:|....:.|::   ||......|.||    ..:...::
Human   298 TKTRTFNTSTGG-------LLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVL 355

  Fly   113 KLRDEVLKKELLDFWRDVLVKKQLGPCWSRDSDLFDSDDTPPLEFYAHAGC-------TAPFAAS 170
            ..:...|:..|..:..:.||   :|     .|.||.:.....||....|.|       ..|:..:
Human   356 LKKHHYLRPSLFVYPEESLV---IG-----SSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVA 412

  Fly   171 LKVRAALEEQASLDQDGPATPTTPG-EL----SADDAAALS------------GEFEATLTK--- 215
            |     :.::..|| |.....|.|| :|    .|||...:.            |:.:|.:.|
Human   413 L-----VPQEEELD-DQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRF 471

  Fly   216 -------ENPL--EEYRTLMKRFVLTKIIVPDSVHQASVKKIAAAAREIIWKLLFDGTPSAEDQN 271
                   |||:  :.:|.|  ..:...::.|:.....::.|:.|..:.:
Human   472 TYRSDSFENPVLQQHFRNL--EALALDLMEPEQAVDLTLPKVEAMNKRL---------------- 518

  Fly   272 KAAELLQEYKGDAGFYGPDDYN 293
              ..|:.|:|   ....|.|||
Human   519 --GSLVDEFK---ELVYPPDYN 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EndoGI	NP_001260489.1	Ku_PK_bind	31..138	CDD:285938	22/119 (18%)
XRCC6	NP_001275905.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		ku70	26..608	CDD:273151	67/347 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..562		67/347 (19%)
		Interaction with DEAF1. /evidence=ECO:0000269|PubMed:22442688	550..609

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12604
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100