DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRL-1 and PTP4A3

DIOPT Version :9

Sequence 1:	NP_001260487.1	Gene:	PRL-1 / 34952	FlyBaseID:	FBgn0024734	Length:	176	Species:	Drosophila melanogaster
Sequence 2:	NP_116000.1	Gene:	PTP4A3 / 11156	HGNCID:	9636	Length:	173	Species:	Homo sapiens

Alignment Length:	167	Identity:	96/167 - (57%)
Similarity:	124/167 - (74%)	Gaps:	2/167 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RPAPALIEYKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAF 75
            ||||..:.||.|:||||..|::.|::.:|.:|||....|||||||.:|:...||..||||.|..|
Human     6 RPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPF 70

  Fly    76 EDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMIRD 140
            :||..||.:||::|..::|.|:.:.|.:|||||||||||||||||||||||.|:|||.|::.||.
Human    71 DDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQ 135

  Fly   141 KRRGAINAKQLSFLEKYKPKARLKHK--NGHKNSCSV 175
            |||||||:|||::||||:||.||:.|  :.||..|.|
Human   136 KRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCV 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRL-1	NP_001260487.1	PTP-IVa	10..163	CDD:350350	89/151 (59%)
PTP4A3	NP_116000.1	PTP-IVa3	5..158	CDD:350511	89/151 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2836
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3714
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54094
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001421
OrthoInspector	1	1.000	-	-		otm41940
orthoMCL	1	0.900	-	-		OOG6_101823
Panther	1	1.100	-	-	LDO	PTHR23339
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X788
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830