DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-Ma2d and CACNA2D4

DIOPT Version :9

Sequence 1:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_758952.4	Gene:	CACNA2D4 / 93589	HGNCID:	20202	Length:	1137	Species:	Homo sapiens

Alignment Length:	1232	Identity:	407/1232 - (33%)
Similarity:	610/1232 - (49%)	Gaps:	196/1232 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AFSFSQ---PLLLLLICGPHGGTFPSTSIHWAEASAADEAVGKWATQFGDELFALAQKITKSQEI 79
            |::|.|   .||.||:.|      .|.|..|.:|....|.|..||..||.:|:....|.:.|..:
Human    43 AWAFVQKTSALLWLLLLG------TSLSPAWGQAKIPLETVKLWADTFGGDLYNTVTKYSGSLLL 101

  Fly    80 KEKYK--EYNARVELKNGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNF 142
            ::|||  |.:.::|..:|.||::..::::..||.||::||:.:.|.||..:.|.|||.:..   |
Human   102 QKKYKDVESSLKIEEVDGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLV---F 163

  Fly   143 TYFSSKYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERV 207
            .|::|...    |..:|    :..|..:.....|..:.||.|.||:|..|||.:|:|::::...:
Human   164 DYYNSVLI----NERDE----KGNFVELGAEFLLESNAHFSNLPVNTSISSVQLPTNVYNKDPDI 220

  Fly   208 LKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWY 272
            |..:..||.|:.||.:|:|.||.|:||||||.||..|.||..:||   |:.:...|:|||.|.||
Human   221 LNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWT---PDENGVITFDCRNRGWY 282

  Fly   273 IETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGAL 337
            |:.||..||||||:|.||||.|.|..:||.||.:||||...|||..|:.|:..|:.|.|||.|.|
Human   283 IQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGIL 347

  Fly   338 VQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGVA 402
            |||..:|.|.|...:|:| ..:|...:..|...|||:|:::.:::.   .|.|||||||::||..
Human   348 VQADRDNREHFKLLVEEL-MVKGVGVVDQALREAFQILKQFQEAKQ---GSLCNQAIMLISDGAV 408

  Fly   403 GNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEV 467
            .:...||:||||       .....||||||:|:||:....::|:||.|:|||:.:.||.:..|.|
Human   409 EDYEPVFEKYNW-------PDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENV 466

  Fly   468 LKYVDVIATPLVLQNEQHPPTWTHAFTDKTYDPKTSNEKRPRLMISVGVPAFDRFYRHANSTNPR 532
            ::|:.|::.|:|: |..|...||.|:.|...  .:|..:...|:.:|.:|.|.:    .|.|...
Human   467 MEYLHVLSRPMVI-NHDHDIIWTEAYMDSKL--LSSQAQSLTLLTTVAMPVFSK----KNETRSH 524

  Fly   533 ARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKM---NPNYNSI 594
            ..||||.|:||.:.::.||...|||||:||:|:.:||||:|.||||||:...||.   .|||||:
Human   525 GILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPKPNYNSV 589

  Fly   595 DFTEVEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPN 659
            |.:|||  :|||:     ||   :|.||:..|.... |:.||...||.:||.....||||..:.:
Human   590 DLSEVE--WEDQA-----ES---LRTAMINRETGTL-SMDVKVPMDKGKRVLFLTNDYFFTDISD 643

  Fly   660 TPFTLGIVMPSEYGKTWIKVGEEVDKNKHMKINISDFFIGENWKVHP------DWVYCKYHYLEG 718
            |||:||:|:...:|: :|.:|     |..::..:.|.       :||      ||:||.......
Human   644 TPFSLGVVLSRGHGE-YILLG-----NTSVEEGLHDL-------LHPDLALAGDWIYCITDIDPD 695

  Fly   719 H-EFKTPEAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIF 782
            | :....||.:| ||.:...|.:                               |::|||..::|
Human   696 HRKLSQLEAMIR-FLTRKDPDLE-------------------------------CDEELVREVLF 728

  Fly   783 DAKVTNSSYGVW---RFESDEERQLIERFRADLRFVATMSGLTRWQFIFGEVEVDTDREFGDYHT 844
            ||.||......|   .....||.:.:    .|:.|:.|.:||.|.....|..:| :||:|    .
Human   729 DAVVTAPMEAYWTALALNMSEESEHV----VDMAFLGTRAGLLRSSLFVGSEKV-SDRKF----L 784

  Fly   845 TAIDET----------WYKSAILQHHEDRAESFVYSVKYYDDPMEDSE-VKVTASHAIFPRDGGK 898
            |..||.          ||:.|    .|..|.|||:::::.:.|....| :.||||.|:......:
Human   785 TPEDEASVFTLDRFPLWYRQA----SEHPAGSFVFNLRWAEGPESAGEPMVVTASTAVAVTVDKR 845

  Fly   899 EAPACVVGFQ----FSHARMWERFFNITAVDHCNHCLPICTDDDVDCVVIDNNAYIVIGQNINTT 959
            .|.|...|.|    |...:.|......:.||  ..|...|.|.|:||.|||||.:|:|.:....|
Human   846 TAIAAAAGVQMKLEFLQRKFWAATRQCSTVD--GPCTQSCEDSDLDCFVIDNNGFILISKRSRET 908

  Fly   960 GKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPLRLLSLGWKYLVGRLF 1024
            |:|.||..|.|:|.::..|:|..:.:||||..||......|....|:.|:.......::|:..|.
Human   909 GRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISAFLTATRWLLQELV 973

  Fly  1025 FEYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSAS------KPKDDSDDENAMFDEPEPDPI 1083
            ...  ::|...|:.:               |.|..:.|      |.|             :.||:
Human   974 LFL--LEWSVWGSWY---------------DRGAEAKSVFHHSHKHK-------------KQDPL 1008

  Fly  1084 YKACDKRSTLYALQPSALVGINDFVE-APSTRPFLVKKIPNSNLVLVVV------NVLMPSRSVR 1141
             :.||....::..|| |:...|..|| .|..:.|:|::||||||:|:|.      ::..|
Human  1009 -QPCDTEYPVFVYQP-AIREANGIVECGPCQKVFVVQQIPNSNLLLLVTDPTCDCSIFPP----- 1066

  Fly  1142 LTTEPQRMEYDKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRLVLT--LQLMPL 1201
            :..|...::|:....|.::. |...|||.:.|:..|.:|.... ||.||....:  |.|:|:
Human  1067 VLQEATEVKYNASVKCDRMR-SQKLRRRPDSCHAFHPEENAQD-CGGASDTSASPPLLLLPV 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	46/126 (37%)
		vWA_VGCC_like	267..461	CDD:238740	87/193 (45%)
		Cache_1	510..587	CDD:280839	35/76 (46%)
CACNA2D4	NP_758952.4	VWA_N	148..264	CDD:285584	46/126 (37%)
		vWA_VGCC_like	277..460	CDD:238740	87/193 (45%)
		MIDAS-like motif	297..301		2/3 (67%)
		Cache_1	487..579	CDD:280839	40/97 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I4180
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1119
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm8612
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.820