DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-Ma2d and cacna2d4a

DIOPT Version :9

Sequence 1:NP_001260486.1 Gene:Ca-Ma2d / 34951 FlyBaseID:FBgn0261999 Length:1215 Species:Drosophila melanogaster
Sequence 2:XP_021330935.1 Gene:cacna2d4a / 568225 ZFINID:ZDB-GENE-041210-213 Length:1105 Species:Danio rerio


Alignment Length:1235 Identity:387/1235 - (31%)
Similarity:595/1235 - (48%) Gaps:221/1235 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 GTFPSTSIHW-----------AEASAADEAVGKWATQFGDELFALAQKITKSQEIKEKYKEYNAR 89
            |...|.::.|           |:...:.|.|.:||..||.:|.||:.:.:.:|.:::||||....
Zfish     7 GRMRSVTLLWVLCSSWTIQTQAQMRISPETVQQWANNFGKQLMALSNRYSGAQLLQKKYKEVEPI 71

  Fly    90 VELK--NGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSSK-YST 151
            |:::  :|.:::|...:.:..||.|||.:|:.:.|.||..:...|||.|.   .|.|::|. .:|
Zfish    72 VKMEEIDGLKMVKEFAEEMENMLGRKMKSVKRMAETAEDADFYHEFNATL---EFDYYNSMLINT 133

  Fly   152 FN--GNSSE-----ELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLK 209
            .|  ||:.|     .||.||                ||.|.||:|:.|.|.||:|::::...:|.
Zfish   134 LNEDGNNIELGGEFPLEENE----------------HFNNLPVNTQQSVVQVPTNVYNKDPDILN 182

  Fly   210 TIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIE 274
            .:..||.|:::|..|::.||.|:||||||.||..|.||..:||   |:.:...|:|.|.|:|||:
Zfish   183 GVFMSEALNDIFISNFEKDPTLTWQYFGSSTGFFRLYPGIKWT---PDENGVVTFDGRNRNWYIQ 244

  Fly   275 TATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGALVQ 339
            .||..|||:|.:|.||||.|.|..:||.||.:||||...|||..::.||..|..:.|||.|.|||
Zfish   245 AATSPKDIIIAVDISGSMKGLRLTIAKHTINTILDTLGENDFVNVIAYSDYVQYVEPCFKGTLVQ 309

  Fly   340 ATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRK-YYDSRHCVTNSTCNQAIMLVTDGVAG 403
            |..:|.|.|...:::| ..:|...:..|.:.:|::|.: ..:.|    .|.|||||||:|||...
Zfish   310 ADLDNREHFKLLVQEL-QVKGEGKVKKAMKESFKILNEAAAEGR----GSLCNQAIMLITDGAME 369

  Fly   404 NTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVL 468
            :..:||:::||.:.:       .||||||:|:|:|....::|:||.|:|||:|:.||.:|.|.|:
Zfish   370 DFQQVFEEFNWPDRK-------VRVFTYLIGRELTFASNVKWIACNNKGYYTHISTLADVQENVM 427

  Fly   469 KYVDVIATPLVLQNEQHPPTWTHAFTDKTYDPKT-----SNEKRPRLMISVGVPAFDRFYRHANS 528
            :|:.|::.|:|: |..|...||.|:.|... |.|     :..:...||.||.:|.|.:    ...
Zfish   428 EYLHVLSRPMVI-NHDHDIIWTEAYMDSVL-PNTAELFNTQAESLLLMTSVAMPVFSK----KEE 486

  Fly   529 TNPRARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKM---NPN 590
            |.....||||.|||||::::.:|...|||||:||:|:.:||||:|.||||||:..:||.   .||
Zfish   487 TLSHGILLGVVGTDVPLKELMRLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYKDGKKLKPKPN 551

  Fly   591 YNSIDFTEVEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFA 655
            |||:|.:|||  :||....        :|.|||:.|.... |:.|:...:|.:||...|.:||:.
Zfish   552 YNSVDLSEVE--WEDTEDA--------LRTAMVKGETGTI-SLDVRATVEKGKRVVFLKNEYFYT 605

  Fly   656 PLPNTPFTLGIVMPSEYGKTWIKVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCKYHYLEGHE 720
            .:..|||:||||:.:.:||........|::..| .:..||..|.:      :|.||:.. ::.|.
Zfish   606 TINETPFSLGIVLTNGHGKNVFIGNVSVEEGLH-DLTASDVSIAQ------EWTYCETD-IDPHH 662

  Fly   721 FKTP--EAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFD 783
            .|..  :|.:|....|                    :.||.            |::.|:...:||
Zfish   663 RKLTQLQAVVRYLTGK--------------------EPDLE------------CDERLLQQTLFD 695

  Fly   784 AKVTNSSYGVWRFESDEERQLIERFRAD----LRFVATMSGLTRWQFIFGEVEVDTDREFGDYHT 844
            |.||......|      ...|:.....|    ..|:.|.|||.| ...:..||....::|    .
Zfish   696 AVVTAPMEAYW------TALLLNASGIDGGVETAFLGTRSGLMR-MIRYAGVEKRVAKKF----L 749

  Fly   845 TAIDE----------TWYKSAILQHHEDRAESFVYSVKYYDDPMEDSE------------VKVTA 887
            ||.|:          .||:.|.    |:.|..|:|.|     |.||:.            |.|:.
Zfish   750 TASDKENIFTLDHFPVWYRRAA----ENPAGRFLYYV-----PTEDNSGVNGRFVIAVTPVTVSV 805

  Fly   888 SHAIFPRDGGKEAPACVVGFQFSHARMWERFFNITAVDHCNHCLPI-------CTDD-DVDCVVI 944
            |.        |.|.|..:|.|.|...:.:||::|....:...|..|       |:|: |:.|.||
Zfish   806 SK--------KTAVAGAIGVQMSLEMLEKRFWSIANQPNDTDCSGIEGLCPLSCSDNPDISCYVI 862

  Fly   945 DNNAYIVIGQNINTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPL 1009
            |:|.:|:|.::....|||.|:..|.||:.:::.|:|..:.:||||..||....:.|....||.|.
Zfish   863 DSNGFIIISRDKADVGKFLGKIEGSVMSQLLKMGMFKRVVLYDYQAMCKAHAHSASGARPLLSPF 927

  Fly  1010 RLLSLGWKYLVGRLFF---EYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDE 1071
            ..|....|:.:....|   ::.....|.            .|.:........||:.|.|..    
Zfish   928 YNLLAALKWFLSNFLFLLLDFNIYNLWH------------SDHFTEAKTSFHSSSKKLKGG---- 976

  Fly  1072 NAMFDEPEPDPIYKACDKRSTLYALQPSALVGINDFVE-APSTRPFLVKKIPNSNLVLVVVNVLM 1135
               |.:|        ||.....:..:|| :...|..:: ....:.|::::||:|||:|||:....
Zfish   977 ---FLQP--------CDTEYPSFVYEPS-IKETNSLIKCGRCQKVFVIQQIPDSNLLLVVIQADC 1029

  Fly  1136 P-SRSV-RLTTEPQRMEYDKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRLVLTLQL 1198
            . ||.. .:|.||:.::|:....|.::. |...|||.|.|:..|..|.... ||.|..:.|::.|
Zfish  1030 DCSRQYPPITMEPKEVKYNASVKCDRMR-SQKIRRRPESCHAYHPQENAKD-CGGAVAISLSIML 1092

  Fly  1199  1198
            Zfish  1093  1092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-Ma2dNP_001260486.1 VWA_N 124..251 CDD:285584 49/134 (37%)
vWA_VGCC_like 267..461 CDD:238740 82/194 (42%)
Cache_1 510..587 CDD:280839 37/76 (49%)
cacna2d4aXP_021330935.1 VWA_N 114..224 CDD:312040 47/128 (37%)
vWA_VGCC_like 237..420 CDD:238740 82/194 (42%)
dCache_1 <472..576 CDD:308398 53/117 (45%)
VGCC_alpha2 652..1032 CDD:312092 110/468 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11344
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 1 1.000 - - mtm6553
orthoMCL 1 0.900 - - OOG6_103783
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.810

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