Protein Alignment Ca-Ma2d and Cacna2d2

DIOPT Version :10

• Sequence 1: NP_723955.2
• Gene: Ca-Ma2d / 34951
• FlyBaseID: FBgn0261999
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: XP_017168985.1
• Gene: Cacna2d2 / 56808
• MGIID: 1929813
• Length: 1160
• Species: Mus musculus
• Alignment Length: 1252
• Identity: 310/1252 - (24%)
• Similarity: 544/1252 - (43%)
• Gaps: 209/1252 - (16%)

  Fly    24 PLLLL-LICGPHGGTFPSTSIHWAEASAADEAVGKWATQFGDELFALAQKITKSQEIKEKYKEYN 87
            ||||| |:..|....:.....|         .:..||.:...|:..:.:.....|:::|.||:..
Mouse    50 PLLLLPLLTAPGASAYSFPQQH---------TMQHWARRLEQEIDGVMRIFGGVQQLREIYKDNR 105

  Fly    88 ARVELKNG--TELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSSKY- 149
            ...|::..  .:|::.:..::..:|.||:.|::.:.:.||...:...:......::..|:.:|.
Mouse   106 NLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKAD 170

  Fly   150 STFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIMWS 214
            :..:...||::|......|   ..::...|.:|.| .|:..:::|.:|::|:..|..:|..:.|:
Mouse   171 AELDDPESEDMERGSKTSA---LRLDFIEDPNFKN-KVNYSYTAVQIPTDIYKGSTVILNELNWT 231

  Fly   215 EHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETATCS 279
            |.|:.||.:|.:.||.|.||.|||.||:.|:|||..|  ..|.:  .|.||.|:|.|||:.|:..
Mouse   232 EALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPW--RAPKK--IDLYDVRRRPWYIQGASSP 292

  Fly   280 KDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGALVQATPEN 344
            ||:||::|.|||::|....:.|.::..:|||.|::|:..:..::.:... :.||. .||||...|
Mouse   293 KDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQP-VSCFT-HLVQANVRN 355

  Fly   345 IEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGVAGNTTEVF 409
            .:||.:.::.: ..:|.......:|.||..|:     ...:|.:.||:.||:.|||......:||
Mouse   356 KKVFKEAVQGM-VAKGTTGYKAGFEYAFDQLQ-----NSNITRANCNKMIMMFTDGGEDRVQDVF 414

  Fly   410 QKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVDVI 474
            :||||.|       ...||||:.:|:....|..:|||||.|:|||..:.::..:.....:|:||:
Mouse   415 EKYNWPN-------RTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVL 472

  Fly   475 ATPLVLQNEQHPPT-WTHAFTDKTYDPKTSNEKRPRLMISVGVPAFDRFYRHANSTNPRARLLGV 538
            ..|:||..:..... ||:.:.|..         ...|:::..:|.|: ..:..........:|||
Mouse   473 GRPMVLAGKDAKQVQWTNVYEDAL---------GLGLVVTGTLPVFN-LTQDGPGEKKNQLILGV 527

  Fly   539 AGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKMNPNYN---SIDFTEVE 600
            .|.||.:.||.:||..|.||.|||.|.:..||||||||:|:|   ......|:.   ::||.:.|
Mouse   528 MGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKP---QVSQTTNFREPVTLDFLDAE 589

  Fly   601 HLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFTLG 665
              .||::..|       ||.:|:..:... |.|.........|.:.|..::|.:.|:.:|.::||
Mouse   590 --LEDENKEE-------IRRSMIDGDKGH-KQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLG 644

  Fly   666 IVMP--SEYGKTWIKVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCKYHYLEGHEFKTP---E 725
            :|:|  |.|               :::.|:||..:         .|......|:..||..|   |
Mouse   645 LVLPPYSTY---------------YLQANLSDQIL---------QVKLPISKLKDFEFLLPSSFE 685

  Fly   726 AELREFLAKMQNDWKWSEQYAEDESDWDD-----KDDLNCGRKTLGDDAYYCNKELVNLLIFDAK 785
            :|...|:|        ..:|.:|.:..|:     |:.:....| :..|:..||..|::.||.|..
Mouse   686 SEGHVFIA--------PREYCKDLNASDNNTEFLKNFIELMEK-VTPDSKQCNNFLLHNLILDTG 741

  Fly   786 VTNSSYGVWRFESDEERQLIERFRAD---------LRFVATMSGLTRWQFIFGEVEVDTDREFGD 841
            :|              :||:||...|         ..|.||..|:||   :|.....:...|
Mouse   742 IT--------------QQLVERVWRDQDLNTYSLLAVFAATDGGITR---VFPNKAAEDWTE--- 786

  Fly   842 YHTTAIDETWYKSAILQHHEDRAESFVYSVKYYDD-----PMEDSEVKVTASHAIFPRDGGKEAP 901
             :....:.::|:.::..|      .:::...:.|.     .:|:..|.|..|.|:....|.:...
Mouse   787 -NPEPFNASFYRRSLDNH------GYIFKPPHQDSLLRPLELENDTVGVLVSTAVELSLGRRTLR 844

  Fly   902 ACVVGFQFSHARMWERFFNITAVD---------HC---NHCLPIC--TDDDVDCVVIDNNAYIVI 952
            ..|||.:.. ...|...|.:.|.:         .|   :||...|  .::|:.||:||:..::|:
Mouse   845 PAVVGVKLD-LEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVL 908

  Fly   953 -GQN--INTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEP--KAGSDGHGLLHPLRLL 1012
             .||  .:..|:||.|...::|.|:.....:...|.||||..|..:|  ..|:...|:..|
Mouse   909 SNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVP---- 969

  Fly  1013 SLGWKYLVGRLFFEYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDE 1077
                      ...::..:.||...|.:..:...:   |..:......:     |.::.|.:
Mouse   970 ----------TIADFLNLAWWTSAAAWSLFQQLL---YGLIYHSWFQA-----DPAEAEGS---- 1012

  Fly  1078 PEPDPIYKACDKRSTLYALQPSALVGINDFVEAPS-TRPFLVKKIPNSNLVLVVVNVLMPSR--S 1139
              |:....:|..:.|.|.. .|.....|..::..: :|.|..:::.|:||:.||....:.|:  :
Mouse  1013 --PETRESSCVMKQTQYYF-GSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEA 1074

  Fly  1140 VRLTTEPQRMEYDKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRLVLTL-QLMPLTI 1203
            .||..:......|....|..:....| ||....|:..:..|:. :.||..:....:| .|:.|.:
Mouse  1075 GRLLQKETHCPADGPEQCELVQRPRY-RRGPHICFDYNATEDT-SDCGRGASFPPSLGVLVSLQL 1137

  Fly  1204 ILVFYL-------THSF 1213
            :|:..|       .|||
Mouse  1138 LLLLGLPPRPQPQVHSF 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_723955.2	VWA_N	124..251	CDD:462464	37/127 (29%)
		vWA_VGCC_like	267..461	CDD:238740	65/193 (34%)
		HK_sensor	547..669	CDD:365792	41/124 (33%)
		VGCC_alpha2	772..>999	CDD:462488	60/259 (23%)
Cacna2d2	XP_017168985.1	VWA_N	144..268	CDD:462464	37/127 (29%)
		vWA_VGCC_like	280..459	CDD:238740	65/193 (34%)
		HK_sensor	536..648	CDD:365792	41/124 (33%)
		VGCC_alpha2	675..1120	CDD:462488	105/512 (21%)