DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-Ma2d and cacna2d1a

DIOPT Version :9

Sequence 1:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_009298560.1	Gene:	cacna2d1a / 561434	ZFINID:	ZDB-GENE-041210-215	Length:	1093	Species:	Danio rerio

Alignment Length:	1256	Identity:	312/1256 - (24%)
Similarity:	545/1256 - (43%)	Gaps:	248/1256 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILTAFSFSQPLLLLLICGPHGGT--FPSTSIHWAEASAADEAVGKWATQFGDELFALAQKITKSQ 77
            ::.|...|..|||||.....|..  ||.:.:           ..|||.:..::|..|....:..:
Zfish     6 MMDALRLSTALLLLLSLCSFGSAIQFPDSFL-----------TRKWAEKMQEDLVQLIDSESGIK 59

  Fly    78 EIKEKYKEYNAR--VELKNGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQ 140
            |:|:.:..:...  |...|..:|::..:..:...||.:..|:..:...||.:.:..::.....:.
Zfish    60 ELKKIFNNFQRHYTVRQNNPRQLVEKASHEIEEFLANRSKALEALATAAENLQKEHQWKEDLDVN 124

  Fly   141 NFTYFSSKYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSE 205
            ...|:::|     ..|..:.||.:....     ::...|..| ..||....::||:|::|::.|.
Zfish   125 ETIYYNAK-----DKSDNQTEPRKNRLI-----LDFTEDPAF-KRPVSYNTTAVHIPTDIYEGST 178

  Fly   206 RVLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRS 270
            .:|..:.|:..||:|||:|.:.||:|.||.|||.||:.|::||:.|.|   :::..|.||.|:|.
Zfish   179 IILNELNWTAALDDVFRKNKEDDPSLHWQVFGSATGLARYFPASPWVD---SKNKIDLYDVRRRP 240

  Fly   271 WYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNG 335
            |||:.|...||::||:|.|||::|....:.:.::..:|:|.|::|:..|:.:::.... :.||..
Zfish   241 WYIQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNIVSFNNSAKS-VACFEN 304

  Fly   336 ALVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDG 400
             ||||...|.:...:.:::: ...|..:..:.::.||..|.....||     :.||:.|||.|||
Zfish   305 -LVQANVRNKKTLKEAVQKI-TANGTTDYKIGFKEAFNQLASMNVSR-----ANCNKIIMLFTDG 362

  Fly   401 VAGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHE 465
            .....:|:|.:||        |....|:||:.:|:.......||:|||.|:|||..:.::..:..
Zfish   363 GEDKASEIFDEYN--------SDKRVRIFTFSVGQHNYDKAPIQYMACHNKGYYYEIPSIGAIRI 419

  Fly   466 EVLKYVDVIATPLV-----LQNEQHPPTWTHAFTD----------------KTYDPKTSNEKRPR 509
            ...:|:||:..|:|     .:|.|    ||:.:.|                ||   :||.|| |:
Zfish   420 NTQEYLDVLGRPMVKADKKAKNVQ----WTNVYVDALELGLVVTGTLPVFNKT---RTSKEK-PK 476

  Fly   510 LMISVGVPAFDRFYRHANSTNPRARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLL 574
                            ..:..|...:|||...||.::||.:||..|.||.|||.|.:..||||||
Zfish   477 ----------------GKNLGPSQMILGVMAIDVSLDDIKRLTPHYTLGPNGYYFAIDPNGYVLL 525

  Fly   575 HPDLRPIGTNGKMNPNYNSIDFTEVEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFH- 638
            ||:|:|.....: .|  .::||.:.|  .||       |..:.||.:|:..|.::     ::||
Zfish   526 HPNLQPKDLKSQ-EP--VTLDFLDAE--MED-------EVKVDIRRSMIDGERSQ-----IRFHT 573

  Fly   639 ----YDKMRRVSEEKQDYFFAPLPNTPFTLGIVMPSEYGKTWIK--VGEEVDKNKHMKINISDFF 697
                .|: |.:.:..:.|.::|:.:..::|.:|:| :|..::||  :|:.:.:.|.        :
Zfish   574 LMKSQDE-RYIDKGFRTYTWSPVTDADYSLALVLP-DYSMSYIKATIGDTITQAKS--------W 628

  Fly   698 IGENWKVHPDWVYCKYHYLEGHEFKTPEAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGR 762
            |.||..|.......|:... |:....|.....:..|:.:|    ..|:..|.:::.|.
Zfish   629 ILENLAVSESLQVDKFEEY-GYTLIAPRDYCEDLKAQNEN----MTQFLIDFNEYIDV------- 681

  Fly   763 KTLGDDAYYCNKELVNLLIFDAKVTNSSYGVWRFESDEERQLIERFRADLRFVATMSGLTR---- 823
            ||..|.  .||.:|:|.|:.||.:|......|     .:.||.:|.:|  :||||..|:||
Zfish   682 KTPNDP--QCNMDLMNRLLLDAGITAELVKHW-----NKNQLSDRIKA--KFVATDGGVTRVYPA 737

  Fly   824 -----WQFIFGEVEVDTDREFGDYHTTAIDETWYKSAILQHHEDRAESFVYSVKYYDDPMEDSEV 883
                 |.   |:.|...    ..::..::|...|....|....::.|..|...:..|..:::..:
Zfish   738 SAGSEWT---GQAETYE----SSFYKRSLDNDLYVFTPLPFTGNKTEESVLVSRAMDLRIDEFWL 795

  Fly   884 KVTASHAIFPRDGGKEAPACVVGFQFSHARMWERFFNITAVDHCNHCLPIC----TDDDVDCVVI 944
            |                || |||.:.......|.|.|.|....|..  .||    .|:.:|||::
Zfish   796 K----------------PA-VVGVKLDVQSWMESFMNTTITPKCEG--EICGCRRNDEYLDCVLL 841

  Fly   945 DNNAYIVIGQN---INTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCK--EEPKAGSDGHG 1004
            |:..::|:...   |:..|:|||.....:|..::...:|.....||||..|:  .|.||.:....
Zfish   842 DDGGFLVMANQDKYIDQIGEFFGMIDPSLMRNLMNVSLFSVNITYDYQALCEPTRESKAAAGLRS 906

  Fly  1005 LLHP--LRLLSLGWKYLVGRLFFEYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDD 1067
            :..|  ..:|::|                |||..|.:    ..::..:|::.......|....|:
Zfish   907 VYVPTIADILNIG----------------WWASAAAW----SIMQQLFVSITFPNFLEAVDISDE 951

  Fly  1068 SDDENAMFDEPEPDPIYKACDKRSTLYAL--QPSALVGINDFVEAPSTRPFLVKKIPNSNLVLVV 1130
            |:           .|..::|.|..|.|..  ..:...|..|....  :|.|:.:|:..:||||:|
Zfish   952 SE-----------TPSKESCIKEQTQYFFDSNDTTFKGTVDCQNC--SRQFIAEKLMKTNLVLIV 1003

  Fly  1131 VNVLMPSRSVRLTTEPQRMEYDKEF-----------PCYKLNMSFYERRRIEECYTVHEDEELYT 1184
            .:..|.|          :|..:|.|           ||. ::.:...|:...||:..:.::|...
Zfish  1004 ADTEMCS----------QMCEEKPFSQEEKPSPGPDPCL-ISQNPRYRKGPMECFDNNVNDEAMC 1057

  Fly  1185 YCGNASRLVLTLQLMPLTIIL 1205
            .....|.|:.:|.::.|.:.:
Zfish  1058 RRNAGSPLLSSLLMLLLPVFM 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	37/126 (29%)
		vWA_VGCC_like	267..461	CDD:238740	59/193 (31%)
		Cache_1	510..587	CDD:280839	27/76 (36%)
cacna2d1a	XP_009298560.1	VWA_N	110..224	CDD:285584	35/124 (28%)
		vWFA	237..415	CDD:294047	59/193 (31%)
		Cache_1	444..532	CDD:280839	36/107 (34%)
		VGCC_alpha2	545..627	CDD:285647	21/97 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8115
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237570at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920