DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-Ma2d and Cachd1

DIOPT Version :9

Sequence 1:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_932154.1	Gene:	Cachd1 / 320508	MGIID:	2444177	Length:	1288	Species:	Mus musculus

Alignment Length:	1270	Identity:	251/1270 - (19%)
Similarity:	440/1270 - (34%)	Gaps:	395/1270 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LLLLLICGPHGGTFPSTSIHWAEASAADEA---VGKWATQFGDELFALA-QKITKSQEIKEKYKE 85
            ||.|:.|...|      ::..|:.|..|||   ..:......:||..:. |:|..|....||
Mouse    36 LLCLVACWILG------AVADADFSILDEAQVLASQMRRLAAEELGVVTMQRIFNSLVYTEK--- 91

  Fly    86 YNARVELKNGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLT---YALQNFTYFSS 147
                  :.||...::.:.|.:.....|.:|.|   ....:.|..::..:||   .|:|:......
Mouse    92 ------ISNGESEVQQLAKKIREKFNRYLDVV---NRNKQVVEASYTAHLTSPLTAIQDCCTIPP 147

  Fly   148 KYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIM 212
            ....|:||                           :||.|....|...:.:.:..|:...
Mouse   148 SMMEFDGN---------------------------FNTNVSRTVSCDRLSTTVNSRAFNP----- 180

  Fly   213 WSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETA- 276
             ...|:.|...|.:|:|.:.||||.|:.||...:||.::.       ...:|:.|.|..|:.|.
Mouse   181 -GRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKFR-------CKGSYEHRSRPIYVSTVR 237

  Fly   277 TCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVN--DIIPCFNGALVQ 339
            ..||.||::|||..|:|..:..:||...:.||.....:|..::|..:..|.  .:..|:...|..
Mouse   238 PQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADAVRTCSLDQCYKTYLSP 302

  Fly   340 ATPE---NIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQA-----IML 396
            ||.|   .:..|...::..|.|..:|   :.:..||||:|.       .:|||..||     |:.
Mouse   303 ATSETKRKMSTFVSSVKPSDSPTQHA---VGFHRAFQLIRS-------TSNSTRFQANTDMVIIY 357

  Fly   397 VTDGVAG-NTTEVFQKYNWG--NGENGTSQMDTRVFTY-LLGKEVTKVREIQWMACL---NRGYY 454
            ::.|:.. :::|..:|....  |.|||.......:.|| |:...||.::|:.::..|   |.|.|
Mouse   358 LSAGITSKDSSEEDKKATLRVINEENGFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKY 422

  Fly   455 SHVQTLDEVHEEVLKYVDVIATPLVLQNEQHPPTWTHAF---------TDKTYDPKTSNEKRPRL 510
            .   ..|.....|:|     .:.:||....:..|....|         .:..:....|:|....|
Mouse   423 G---IPDRTALPVIK-----GSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGL 479

  Fly   511 MISVGVPAFDRFYRHANSTNPRARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLH 575
            :::|..|.:     ..|      .|||:.|.||.:..|.:....|:..:..|:|::.:.||.|:|
Mouse   480 IMTVSKPCY-----FGN------LLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMH 533

  Fly   576 PDLR--------PIGTNGKMNPNYNSIDFTEVEHLFEDQSPREPGESILHIRNAMVRHEANEFKS 632
            |.|.        |:.|           |....|::.:.:..|:...| |.:.:.::....|.
Mouse   534 PSLTRPYLLSEPPLHT-----------DIIHYENIPKFELVRQNILS-LPLGSQIITVPVNS--- 583

  Fly   633 ISVKFHYDKMRRVSEEKQD--YFFAPLPNTPFTLGIVMPSEYGKTWIKVGEEVDKNKHMKINISD 695
             |:.:|.:|:|...:|..:  |.:..:.:|.|.|.||:        |:....|.:.|::....|.
Mouse   584 -SLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVV--------IQPEIPVKQLKNLNTVPSS 639

  Fly   696 FFIGENWKVHPDWVYCKYHYLE-------------------------GHEFKTPEAELREFLAKM 735
            ..:              ||.|:                         ...|.:|...|.:...|
Mouse   640 KLL--------------YHRLDLLGQPSACLHFKQLATLESPTVMLSAGSFSSPYEHLSQPETK- 689

  Fly   736 QNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFDAKVTNSSYGVW--RFES 798
                :..|.|....|| :.:...|.|.|.          .:.|.::..:.||:.    |  :.|.
Mouse   690 ----RMVEHYTAYLSD-NTRLIANPGLKF----------SVRNEVMATSHVTDE----WMTQMEM 735

  Fly   799 DEERQLIERFRADLRFVATMSGLTRWQFIFGEVEVDTDREFGDYHTTAIDET---WYKSAILQ-- 858
            ......|.|     |::||.:|:.|   |:.          |.....|.|.|   ||..|:..
Mouse   736 SSLNTYIVR-----RYIATPNGVLR---IYP----------GSLMDKAFDPTRRQWYLHAVANPG 782

  Fly   859 -------HHEDRAESFVYSVKYYDDPMEDSEVKVTASHAIFPRDGGKEAPACVVGFQFSHARMWE 916
                   :.:.....:|.::.:   .:..|..::::.|.:           .|:|..|:     .
Mouse   783 LISLTGPYLDVGGAGYVVTISH---TIHSSSTQLSSGHTV-----------AVMGIDFT-----L 828

  Fly   917 RFFNITAVDHCNHCLPICTDD---DVDCVVIDNNAYIVIGQNINTTGKFFGEFHGDVMTAMVERG 978
            |:|....:|    .||:|..|   .:.|.::::..|:|.              |..::
Mouse   829 RYFYKVLMD----LLPVCNQDGGNKIRCFIMEDRGYLVA--------------HPTLV------- 868

  Fly   979 IFLSIEVYDYQEQCKEEPKAGSDGHGLLHPLRLLSLGWKYLVGRLFFEYQRIQWWADGAPFMEYT 1043
                            :||    ||                                 ||
Mouse   869 ----------------DPK----GH---------------------------------AP----- 875

  Fly  1044 DEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDEPEPDPIYK-ACD-------KRSTLYALQPSA 1100
              :|.:::        :..:|...:|..|      .|:.:.| .|:       :||  |....|.
Mouse   876 --LEQQHI--------THKEPLVANDILN------HPNFVKKNLCNSFSDRTVQRS--YKFNTSL 922

  Fly  1101 LVGINDFVEAPSTRPFLVKKIPNSNLVLVVVNVLMPSRSV-------RLTTEPQRMEYDK-EFPC 1157
            :..:.:.|.......:.:.:||.:|..:.:||....|.:.       ||.....|||.:: |.||
Mouse   923 VGDLTNLVHGSHCSKYRLTRIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPC 987

  Fly  1158 --------YKLNMSFYERRRIEECYTVHEDEELYT 1184
                    ...|::..|.|. ..| .||::...||
Mouse   988 ECPLEVNECTGNLTNAENRN-PSC-EVHQEPVTYT 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	27/129 (21%)
		vWA_VGCC_like	267..461	CDD:238740	57/211 (27%)
		Cache_1	510..587	CDD:280839	22/84 (26%)
Cachd1	NP_932154.1	VWA_N	103..218	CDD:285584	31/150 (21%)
		vWFA	227..422	CDD:294047	56/204 (27%)
		Cache_1	470..537	CDD:280839	21/77 (27%)
		Cache_1	786..867	CDD:280839	17/117 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1176
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1187..1237
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810