Protein Alignment Ca-Ma2d and Cacna2d4

DIOPT Version :9

• Sequence 1: NP_001260486.1
• Gene: Ca-Ma2d / 34951
• FlyBaseID: FBgn0261999
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: NP_001178680.2
• Gene: Cacna2d4 / 312668
• RGDID: 1562038
• Length: 1144
• Species: Rattus norvegicus
• Alignment Length: 1232
• Identity: 406/1232 - (32%)
• Similarity: 606/1232 - (49%)
• Gaps: 189/1232 - (15%)

  Fly    18 AFSF--SQPLLLLLICGPHGGTFPSTSIHWAEASAAD--EAVGKWATQFGDELFALAQKITKSQE 78
            |::|  ..|::|.|:       ...||:..|.:.|..  |.|..||..||.:|::...:.:.|..
  Rat    50 AWTFLRKMPIVLWLL-------LLDTSLPTARSQATIPLETVKLWAETFGRDLYSTVTRYSGSLL 107

  Fly    79 IKEKYKEYNARVELK--NGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQN 141
            :::|||:....:::|  :|.||:|..::::..||.||::||..:.|.||..:.|.|||.:..
  Rat   108 LQKKYKDAEPSLKIKEVDGLELVKKFSEDMETMLRRKVEAVESLVEAAEEADLNHEFNASLV--- 169

  Fly   142 FTYFSSKYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSER 206
            |.|::|.......:....:|.. |||.       |..|.||.|..|:...|||.:|:|::::...
  Rat   170 FNYYNSVLINEKDDKGNYVELG-AEFL-------LESDAHFNNLRVNVSMSSVQLPTNVYNKDPD 226

  Fly   207 VLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSW 271
            :|..:..||.|:.||.:|:|.||.|:||||||.||..|.||..:||   |:.:....:|||.|.|
  Rat   227 ILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYPGIKWT---PDENGVIAFDCRNRGW 288

  Fly   272 YIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGA 336
            ||:.||..||||||:|.||||.|.|..:||.|:.:||||...|||..|:.|:..|:.|.|||.|.
  Rat   289 YIQAATSPKDIVILVDMSGSMKGLRMAIAKHTVTTILDTLGENDFVNIIAYNDYVHYIEPCFKGI 353

  Fly   337 LVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGV 401
            ||||..:|.|.|.|.:::| ..:|...::.|...|||:|:::.:||.   .|.|||||||||||.
  Rat   354 LVQADRDNREHFKQLVDEL-MVKGVGIVSQALIEAFQILKQFQESRQ---GSLCNQAIMLVTDGA 414

  Fly   402 AGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEE 466
            ..:...||:.|||.:.:       .||||||:|:|||....::|:||.|:|||:.:.||.:..|.
  Rat   415 VEDYEPVFETYNWPDRK-------VRVFTYLIGREVTFADRMKWIACNNKGYYTQISTLADAQEN 472

  Fly   467 VLKYVDVIATPLVLQNEQHPPTWTHAFTDKTYDPKTSNEKRPRLMISVGVPAFDRFYRHANSTNP 531
            |::|:.|::.|:|: |..|...||.|:.|...  .||..:...|:.:|.:|.|.:    .|.|..
  Rat   473 VMEYLHVLSRPMVI-NHDHDIIWTEAYMDSRL--LTSEAQSLMLLTTVAMPVFSK----KNETRS 530

  Fly   532 RARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKM---NPNYNS 593
            ...||||.|:||.:.::.||...|||||:||:|:.:||||:|.||||||:...||.   .|||||
  Rat   531 HGILLGVVGSDVTLRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLKPKPNYNS 595

  Fly   594 IDFTEVEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLP 658
            :|.:|||  :|||:      .||  |.||:..|... .|:.||...||.:||.....||||..:.
  Rat   596 VDLSEVE--WEDQA------EIL--RTAMINGETGS-HSMDVKVPLDKGKRVLFLTNDYFFTDIS 649

  Fly   659 NTPFTLGIVMPSEYGKTWIKVGEEVDKNKHMKINISDFFIGENWKVHP------DWVYCKYHYLE 717
            :|||:||:|:...:|: :|.:|     |..::..:.|.       :||      ||:||......
  Rat   650 DTPFSLGVVLTRGHGE-YILLG-----NTSVEEGLHDL-------LHPDLTLASDWIYCITDIDP 701

  Fly   718 GH-EFKTPEAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLI 781
            .| :....||.:| ||..:..|.:                               |::|||..::
  Rat   702 DHRKLSQLEAVVR-FLTGVDPDLE-------------------------------CDEELVREVL 734

  Fly   782 FDAKVTNSSYGVWRF----ESDEERQLIERFRADLRFVATMSGLTRWQFIFGEVEVDTDREFGDY 842
            |||.||......|..    .|:|....:|     :.|:.|.:||.|.....|..:| :||:|
  Rat   735 FDAVVTAPMEAYWTALALNISEESEPGVE-----VAFLGTRAGLLRRSLFVGSEKV-SDRKF--- 790

  Fly   843 HTTAIDET----------WYKSAILQHHEDRAESFVYSVKYYDDPMEDS---EVKVTASHAIFPR 894
             .|..||.          ||:.|    .|....|||:::::.:.|  ||   .|.|.||.||...
  Rat   791 -LTPEDEASIFTMDHFPLWYRQA----SEQPPGSFVFNLRWAEGP--DSPGKPVAVRASTAITVT 848

  Fly   895 DGGKEAPACVVGFQFSHARMWERFFNITAVDHCN----HCLPICTDDDVDCVVIDNNAYIVIGQN 955
            ..||.|.|..||.|.....:..:|:  .|:..||    .|...|.|.|:||.|||||.:|:|.:.
  Rat   849 VDGKTAIAAAVGIQMQADYLQRQFW--AAMQQCNTVEGPCPKRCQDTDLDCFVIDNNGFILISER 911

  Fly   956 INTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPLRLLSLGWKYLV 1020
            ....|:..||..|.:||.::..|:|..:.:||||..||......|....|:.||.......|:|:
  Rat   912 PQEIGRLLGEADGALMTQLLSMGVFSRVTMYDYQAMCKPPDHHHSAAESLISPLSAFLTVAKWLL 976

  Fly  1021 GR-LFFEYQRIQW--WADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDEPEPDP 1082
            .. |.|.::...|  |.|                      |.|.:|.......::...|...|
  Rat   977 HECLLFLFEWSAWGSWQD----------------------KGSEAKAVFHHSHKHKKQDLLHP-- 1017

  Fly  1083 IYKACDKRSTLYALQPSALVGINDFVEAPS-TRPFLVKKIPNSNLVLVVVNVLMP-SRSVRLTTE 1145
                ||....::..| :|:...|..:|... .:.|::::||:|||:|:|.:.... |....:..|
  Rat  1018 ----CDTEYPVFVHQ-TAIREANGIIECGGCQKTFVMQQIPSSNLLLLVTDRTCDCSAYSPILQE 1077

  Fly  1146 PQRMEYDKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRLVLTLQLMPLTIILVF 1207
            ...::|:....|.::. |...|||...|:..|.:|.... ||.||.   ||...||.::.::
  Rat  1078 ATEVKYNASVKCNRMR-SQKPRRRPGSCHAFHPEENAQD-CGGASD---TLPSSPLLLLALW 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	46/126 (37%)
		vWA_VGCC_like	267..461	CDD:238740	90/193 (47%)
		Cache_1	510..587	CDD:280839	35/76 (46%)
Cacna2d4	NP_001178680.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4184
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm9092
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.770