DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-Ma2d and Cacna2d3

DIOPT Version :9

Sequence 1:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_017455566.2	Gene:	Cacna2d3 / 306243	RGDID:	631361	Length:	1091	Species:	Rattus norvegicus

Alignment Length:	1222	Identity:	378/1222 - (30%)
Similarity:	592/1222 - (48%)	Gaps:	193/1222 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LICGPHGGT-FPSTSIHWA--------EASAADEAVGKWATQFGDELFALAQKITKSQEIKEKYK 84
            |.|...|.: ..:|::.:|        |.......|..||:.||.|:.::|.|.:.||.:::|||
  Rat     7 LCCASRGASALLATALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYK 71

  Fly    85 EYNARVELK--NGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSS 147
            ||...|.::  :|.:|:|.:.||:..|..:|.:|||.:.|.||..:...||:.          ..
  Rat    72 EYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDA----------DL 126

  Fly   148 KYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIM 212
            :|..||.....|.: .:..|..:.:...|.|:.||.|.||:...|.|.||:|::::...::..:.
  Rat   127 QYEYFNAVLINERD-KDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVY 190

  Fly   213 WSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETAT 277
            |||.|::||..|:..||:|.||||||..|..|.||..:|   .|:.:....:|||.|.|||:.||
  Rat   191 WSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKW---EPDENGVIAFDCRNRKWYIQAAT 252

  Fly   278 CSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGALVQATP 342
            ..||:|||:|.||||.|.|..:||.|:.|||||..::|||.|:.|:.|::.:.||.||.||||..
  Rat   253 SPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADR 317

  Fly   343 ENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGVAGNTTE 407
            .|.|.|.:.:::| ..:|...|.:|...||.:|.   |..|....|.|:|||||:|||.......
  Rat   318 TNKEHFREHLDKL-FAKGIGMLDIALNEAFNVLS---DFNHTGQGSICSQAIMLITDGAVDTYDT 378

  Fly   408 VFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVD 472
            :|.||||       .:...|:||||:|:|......::||||.|:|:::.:.||.:|.|.|::|:.
  Rat   379 IFAKYNW-------PERKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLH 436

  Fly   473 VIATPLVLQNEQHPPTWTHAFTDKTYD--PKTSNEKRPRLMISVGVPAFDRFYRHANSTNPRARL 535
            |::.|.|: :::|...||.|:.|.|..  .|.::::...||.:|.:|.|.:    .|.|..:..|
  Rat   437 VLSRPKVI-DQEHDVVWTEAYIDSTLPQAQKLADDQGLVLMTTVAMPVFSK----QNETRSKGIL 496

  Fly   536 LGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGK--MNPNYNSIDFTE 598
            |||.||||||:::.|....||||::||:|.::||||:|.||:|||:...||  ..|||:|:|.:|
  Rat   497 LGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSE 561

  Fly   599 VEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFT 663
            ||  :||:      :.:|  |||||..:..:| |:.||...||.:||.....||::..:...||:
  Rat   562 VE--WEDR------DDVL--RNAMVNRKTGKF-SMEVKKTVDKGKRVLVMTNDYYYTDIKGAPFS 615

  Fly   664 LGIVMPSEYGKTW----IKVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCKYHYLEGHEFKTP 724
            ||:.:...:||.:    :.:.|.:...:|..::::|           :|.||.......|...:.
  Rat   616 LGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLAD-----------EWSYCNTDLHPEHRHLSQ 669

  Fly   725 EAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFDAKVTNS 789
            ...::.:|.                           |::.|    ..|:|||:..::|||.|:..
  Rat   670 LEAIKLYLK---------------------------GKEPL----LQCDKELIQEVLFDAVVSAP 703

  Fly   790 SYGVW------RFESDEERQLIERFRADLRFVATMSGLTRWQFIFGEVEVDTDREFGDYHTTAID 848
            ....|      :.|:.::       ..::.|:.|.:||:|.....|..:: |:::|    ..|.|
  Rat   704 IEAYWTSLALNKSENSDK-------GVEVAFLGTRTGLSRINLFVGAEQL-TNQDF----LKARD 756

  Fly   849 E----------TWYKSAILQHHEDRAESFVYSVKYYDDPMEDSEVKVTASHAIFPRDGGKEAPAC 903
            :          .||:.|.    |....|||||:.:....:..|.| ||||.:|...|..|.....
  Rat   757 KENIFNADHFPLWYRRAA----EQIPGSFVYSIPFSTGTVNKSNV-VTASTSIQLLDERKSPVVA 816

  Fly   904 VVGFQ----FSHARMWERFFNITAVDHC----NHCLPICTDDDVDCVVIDNNAYIVIGQNINTTG 960
            .||.|    |...:.|      ||...|    ..|...|.|:.|:|.:||||.:|::.::...||
  Rat   817 AVGIQMKLEFFQRKFW------TASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTG 875

  Fly   961 KFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPLRLLSLGWKYLVGRL-- 1023
            .||||..|.||..::..|.|..|.:||||..|:...::....||||.|.:......|::|..|
  Rat   876 DFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIVTELVL 940

  Fly  1024 -FFEYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDEPEPDPIYKAC 1087
             ..|:....||        ::|.            .:.|.|.|...          ||      |
  Rat   941 FLVEFNLCSWW--------HSDM------------TAKAQKLKQTL----------EP------C 969

  Fly  1088 DKRSTLYALQPSALVGINDFVEAPSTRPFLVKKIPNSNLVLVVVNVLMPSRSVR-LTTEPQRMEY 1151
            |.....:..:.:......:......::.|::::||:|||.:|||:......||. :|..|..:.|
  Rat   970 DTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRY 1034

  Fly  1152 DKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRL--VLTLQLMPL 1201
            ::...|.:|..... |||.|.|:..|.:|.. ..||.||.|  .:.|.|:||
  Rat  1035 NESLKCERLKAQKI-RRRPESCHGFHPEENA-RECGGASSLQAQVALLLLPL 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	41/126 (33%)
		vWA_VGCC_like	267..461	CDD:238740	82/193 (42%)
		Cache_1	510..587	CDD:280839	37/78 (47%)
Cacna2d3	XP_017455566.2	VWA_N	113..229	CDD:400621	41/126 (33%)
		vWA_VGCC_like	242..425	CDD:238740	82/193 (42%)
		HK_sensor	<446..506	CDD:365792	22/63 (35%)
		PDC2_MCP_like	508..622	CDD:350337	50/124 (40%)
		VGCC_alpha2	655..1068	CDD:400667	121/504 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4184
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm9092
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.770