Protein Alignment Ca-Ma2d and Cacna2d3

DIOPT Version :10

• Sequence 1: NP_723955.2
• Gene: Ca-Ma2d / 34951
• FlyBaseID: FBgn0261999
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: XP_063131356.1
• Gene: Cacna2d3 / 306243
• RGDID: 631361
• Length: 1091
• Species: Rattus norvegicus
• Alignment Length: 1222
• Identity: 378/1222 - (30%)
• Similarity: 592/1222 - (48%)
• Gaps: 193/1222 - (15%)

  Fly    29 LICGPHGGT-FPSTSIHWA--------EASAADEAVGKWATQFGDELFALAQKITKSQEIKEKYK 84
            |.|...|.: ..:|::.:|        |.......|..||:.||.|:.::|.|.:.||.:::|||
  Rat     7 LCCASRGASALLATALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYK 71

  Fly    85 EYNARVELK--NGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSS 147
            ||...|.::  :|.:|:|.:.||:..|..:|.:|||.:.|.||..:...||:.          ..
  Rat    72 EYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDA----------DL 126

  Fly   148 KYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIM 212
            :|..||.....|.: .:..|..:.:...|.|:.||.|.||:...|.|.||:|::::...::..:.
  Rat   127 QYEYFNAVLINERD-KDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVY 190

  Fly   213 WSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETAT 277
            |||.|::||..|:..||:|.||||||..|..|.||..:|   .|:.:....:|||.|.|||:.||
  Rat   191 WSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKW---EPDENGVIAFDCRNRKWYIQAAT 252

  Fly   278 CSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGALVQATP 342
            ..||:|||:|.||||.|.|..:||.|:.|||||..::|||.|:.|:.|::.:.||.||.||||..
  Rat   253 SPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADR 317

  Fly   343 ENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGVAGNTTE 407
            .|.|.|.:.:::| ..:|...|.:|...||.:|.   |..|....|.|:|||||:|||.......
  Rat   318 TNKEHFREHLDKL-FAKGIGMLDIALNEAFNVLS---DFNHTGQGSICSQAIMLITDGAVDTYDT 378

  Fly   408 VFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVD 472
            :|.||||       .:...|:||||:|:|......::||||.|:|:::.:.||.:|.|.|::|:.
  Rat   379 IFAKYNW-------PERKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLH 436

  Fly   473 VIATPLVLQNEQHPPTWTHAFTDKTYD--PKTSNEKRPRLMISVGVPAFDRFYRHANSTNPRARL 535
            |::.|.|: :::|...||.|:.|.|..  .|.::::...||.:|.:|.|.:    .|.|..:..|
  Rat   437 VLSRPKVI-DQEHDVVWTEAYIDSTLPQAQKLADDQGLVLMTTVAMPVFSK----QNETRSKGIL 496

  Fly   536 LGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGK--MNPNYNSIDFTE 598
            |||.||||||:::.|....||||::||:|.::||||:|.||:|||:...||  ..|||:|:|.:|
  Rat   497 LGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSE 561

  Fly   599 VEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFT 663
            ||  :||:      :.:|  |||||..:..:| |:.||...||.:||.....||::..:...||:
  Rat   562 VE--WEDR------DDVL--RNAMVNRKTGKF-SMEVKKTVDKGKRVLVMTNDYYYTDIKGAPFS 615

  Fly   664 LGIVMPSEYGKTW----IKVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCKYHYLEGHEFKTP 724
            ||:.:...:||.:    :.:.|.:...:|..::::|           :|.||.......|...:.
  Rat   616 LGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLAD-----------EWSYCNTDLHPEHRHLSQ 669

  Fly   725 EAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFDAKVTNS 789
            ...::.:|.                           |::.|    ..|:|||:..::|||.|:..
  Rat   670 LEAIKLYLK---------------------------GKEPL----LQCDKELIQEVLFDAVVSAP 703

  Fly   790 SYGVW------RFESDEERQLIERFRADLRFVATMSGLTRWQFIFGEVEVDTDREFGDYHTTAID 848
            ....|      :.|:.::       ..::.|:.|.:||:|.....|..:: |:::|    ..|.|
  Rat   704 IEAYWTSLALNKSENSDK-------GVEVAFLGTRTGLSRINLFVGAEQL-TNQDF----LKARD 756

  Fly   849 E----------TWYKSAILQHHEDRAESFVYSVKYYDDPMEDSEVKVTASHAIFPRDGGKEAPAC 903
            :          .||:.|.    |....|||||:.:....:..|.| ||||.:|...|..|.....
  Rat   757 KENIFNADHFPLWYRRAA----EQIPGSFVYSIPFSTGTVNKSNV-VTASTSIQLLDERKSPVVA 816

  Fly   904 VVGFQ----FSHARMWERFFNITAVDHC----NHCLPICTDDDVDCVVIDNNAYIVIGQNINTTG 960
            .||.|    |...:.|      ||...|    ..|...|.|:.|:|.:||||.:|::.::...||
  Rat   817 AVGIQMKLEFFQRKFW------TASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTG 875

  Fly   961 KFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPLRLLSLGWKYLVGRL-- 1023
            .||||..|.||..::..|.|..|.:||||..|:...::....||||.|.:......|::|..|
  Rat   876 DFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIVTELVL 940

  Fly  1024 -FFEYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDEPEPDPIYKAC 1087
             ..|:....||        ::|.            .:.|.|.|...          ||      |
  Rat   941 FLVEFNLCSWW--------HSDM------------TAKAQKLKQTL----------EP------C 969

  Fly  1088 DKRSTLYALQPSALVGINDFVEAPSTRPFLVKKIPNSNLVLVVVNVLMPSRSVR-LTTEPQRMEY 1151
            |.....:..:.:......:......::.|::::||:|||.:|||:......||. :|..|..:.|
  Rat   970 DTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRY 1034

  Fly  1152 DKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRL--VLTLQLMPL 1201
            ::...|.:|..... |||.|.|:..|.:|.. ..||.||.|  .:.|.|:||
  Rat  1035 NESLKCERLKAQKI-RRRPESCHGFHPEENA-RECGGASSLQAQVALLLLPL 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_723955.2	VWA_N	124..251	CDD:462464	41/126 (33%)
		vWA_VGCC_like	267..461	CDD:238740	82/193 (42%)
		HK_sensor	547..669	CDD:365792	50/123 (41%)
		VGCC_alpha2	772..>999	CDD:462488	73/250 (29%)
Cacna2d3	XP_063131356.1	None