DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-Ma2d and Cacna2d2

DIOPT Version :9

Sequence 1:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_783182.1	Gene:	Cacna2d2 / 300992	RGDID:	631360	Length:	1157	Species:	Rattus norvegicus

Alignment Length:	1258	Identity:	312/1258 - (24%)
Similarity:	545/1258 - (43%)	Gaps:	224/1258 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLLLL-LICGPHGGTFPSTSIHWAEASAADEAVGKWATQFGDELFALAQKITKSQEIKEKYKEYN 87
            ||||| |:..|....:.....|         .:..||.:...|:..:.:.....|:::|.||:..
  Rat    50 PLLLLPLLTAPGASAYSFPQQH---------TMQHWARRLEQEIDGVMRIFGGVQQLREIYKDNR 105

  Fly    88 ARVELKNG--TELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSSKYS 150
            ...:::..  .:|::.:..::..:|.||:.|::.:.:.||...:...:......::..|:.:|
  Rat   106 NLFDVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAK-- 168

  Fly   151 TFNGNSSEELEPNEAEFAWMYRNMELNPDT-----HFYNTP-----VDTEHSSVHVPSNIWDRSE 205
                 :..||:..|:|      :||....|     .|...|     |:..:::|.:|::|:..|.
  Rat   169 -----ADAELDDPESE------DMERGSKTSALRLDFIEEPNFKNKVNYSYTAVQIPTDIYKGST 222

  Fly   206 RVLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRS 270
            .:|..:.|:|.|:.||.:|.:.||.|.||.|||.||:.|:|||..|  ..|.:  .|.||.|:|.
  Rat   223 VILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPW--RAPKK--IDLYDVRRRP 283

  Fly   271 WYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNG 335
            |||:.|:..||:||::|.|||::|....:.|.::..:|||.|::|:..:..::.:... :.||.
  Rat   284 WYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQP-VSCFT- 346

  Fly   336 ALVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDG 400
            .||||...|.:||.:.::.: ..:|.......:|.||..|:     ...:|.:.||:.||:.|||
  Rat   347 HLVQANVRNKKVFKEAVQGM-VAKGTTGYKAGFEYAFDQLQ-----NSNITRANCNKMIMMFTDG 405

  Fly   401 VAGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHE 465
            ......:||:||||.|       ...||||:.:|:....|..:|||||.|:|||..:.::..:..
  Rat   406 GEDRVQDVFEKYNWPN-------RTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRI 463

  Fly   466 EVLKYVDVIATPLVLQNEQHPPT-WTHAFTDKTYDPKTSNEKRPRLMISVGVPAFDRFYRHANST 529
            ...:|:||:..|:||..:..... ||:.:.|..         ...|:::..:|.|: ..:.....
  Rat   464 NTQEYLDVLGRPMVLAGKDAKQVQWTNVYEDAL---------GLGLVVTGTLPVFN-LTQDGPGD 518

  Fly   530 NPRARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKMNPNYNSI 594
            .....:|||.|.||.:.||.:||..|.||.|||.|.:..||||||||:|:|..||.: .|  .::
  Rat   519 KKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQITNFR-EP--VTL 580

  Fly   595 DFTEVEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPN 659
            ||.:.|  .||::..|       ||.:|:..:... |.|.........|.:.|..::|.:.|:.:
  Rat   581 DFLDAE--LEDENKEE-------IRRSMIDGDKGH-KQIRTLVKSLDERYIDEVIRNYTWVPIRS 635

  Fly   660 TPFTLGIVMP--SEYGKTWIKVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCKYHYLEGHEFK 722
            |.::||:|:|  |.|               :::.|:||..:         .|......|:..||.
  Rat   636 TNYSLGLVLPPYSTY---------------YLQANLSDQIL---------QVKLPISKLKDFEFL 676

  Fly   723 TP---EAELREFLAKMQNDWKWSEQYAEDESDWDD-----KDDLNCGRKTLGDDAYYCNKELVNL 779
            .|   |:|...|:|        ..:|.:|.:..|:     |:.:....| :..|:..||..|::.
  Rat   677 LPSSFESEGHVFIA--------PREYCKDLNASDNNTEFLKNFIELMEK-VTPDSKQCNNFLLHN 732

  Fly   780 LIFDAKVTNSSYGVWRFESDEERQLIERFRAD---------LRFVATMSGLTRWQFIFGEVEVDT 835
            ||.|..:|              :||:||...|         ..|.||..|:||   :|.....:.
  Rat   733 LILDTGIT--------------QQLVERVWRDQDLNTYSLLAVFAATDGGITR---VFPNKAAED 780

  Fly   836 DREFGDYHTTAIDETWYKSAILQHHEDRAESFVYSVKYYDD-----PMEDSEVKVTASHAIFPRD 895
            ..|    :....:.::|:.::    ::|  .:::...:.|.     .:|:..|.|..|.|:....
  Rat   781 WTE----NPEPFNASFYRRSL----DNR--GYIFKPPHQDSLLRPLELENDTVGVLVSTAVELSL 835

  Fly   896 GGKEAPACVVGFQFSHARMWERFFNITAVD---------HC---NHCLPIC--TDDDVDCVVIDN 946
            |.:.....|||.:.. ...|...|.:.|.:         .|   :||...|  .::|:.||:||:
  Rat   836 GRRTLRPAVVGVKLD-LEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLIDD 899

  Fly   947 NAYIVI-GQN--INTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEP--KAGSDGHGLL 1006
            ..::|: .||  .:..|:||.|...::|.|:.....:...|.||||..|..:|  ..|:...|:.
  Rat   900 GGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVF 964

  Fly  1007 HPLRLLSLGWKYLVGRLFFEYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDE 1071
            .|              ...::..:.||...|.:..:...:   |..:......:     |.::.|
  Rat   965 VP--------------TIADFLNLAWWTSAAAWSLFQQLL---YGLIYHSWFQA-----DPAEAE 1007

  Fly  1072 NAMFDEPEPDPIYKACDKRSTLYALQPSALVGINDFVEAPS-TRPFLVKKIPNSNLVLVVVNVLM 1135
            .:      |:....:|..:.|.|.. .|.....|..::..: :|.|..:::.|:||:.||....:
  Rat  1008 GS------PETRESSCVMKQTQYYF-GSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPL 1065

  Fly  1136 PSRSV--RLTTEPQRMEYDKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRLVLTL-Q 1197
            .|:..  ||..:......|....|..:....| |.....|:..:..|:. :.||..:....:| .
  Rat  1066 CSQCEVGRLLQKETHCPADGPEQCELVQRPRY-RTGPHICFDYNATEDT-SDCGRGASFPPSLGV 1128

  Fly  1198 LMPLTIILVFYL-------THSF 1213
            |:.|.::|:..|       .|||
  Rat  1129 LVSLQLLLLLGLPPRPQPQIHSF 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	39/136 (29%)
		vWA_VGCC_like	267..461	CDD:238740	65/193 (34%)
		Cache_1	510..587	CDD:280839	32/76 (42%)
Cacna2d2	NP_783182.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		VWA_N	144..268	CDD:285584	39/136 (29%)
		vWA_VGCC_like	280..459	CDD:238740	65/193 (34%)
		MIDAS-like motif	300..304		2/3 (67%)
		Cache_1	488..576	CDD:280839	35/98 (36%)
		VGCC_alpha2	583..666	CDD:285647	24/116 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237570at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920