DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-Ma2d and Cacna2d1

DIOPT Version :9

Sequence 1:NP_001260486.1 Gene:Ca-Ma2d / 34951 FlyBaseID:FBgn0261999 Length:1215 Species:Drosophila melanogaster
Sequence 2:NP_037051.2 Gene:Cacna2d1 / 25399 RGDID:2247 Length:1091 Species:Rattus norvegicus


Alignment Length:1239 Identity:332/1239 - (26%)
Similarity:560/1239 - (45%) Gaps:240/1239 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 WAEASAADE------AVGKWATQFGDELFALAQK---ITKSQEIKEKYKEYNARVELKNGTELIK 100
            |....:::|      .:..|..:..::|..||:.   :|:..:|.|||::... ||..|..:|::
  Rat    17 WLIGPSSEEPFPSPVTIKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYT-VEPNNARQLVE 80

  Fly   101 SITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSSKYSTFNGNSSEELEP--N 163
            ...:::.::|:.:..|:..:...||.|....::...:|.....|:         |:.::|:|  |
  Rat    81 IAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFASNEVVYY---------NAKDDLDPERN 136

  Fly   164 EAEFAWMYRNMELNP----DTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVFRQN 224
            |:|..    :..:.|    |.:| ...:..:|::||:|::|::.|..||..:.|:..|||||::|
  Rat   137 ESESG----SQRIKPVFIEDANF-GRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRN 196

  Fly   225 YQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETATCSKDIVILLDHS 289
            ...||.|.||.|||.||:.|:|||:.|.|.....:..|.||.|:|.|||:.|...||::||:|.|
  Rat   197 RDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVS 261

  Fly   290 GSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGALVQATPENIEVFNQQIEQ 354
            ||::|....:.:.::..:|:|.|::||..:..::|...| :.||. .||||...|.:|....:..
  Rat   262 GSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD-VSCFQ-HLVQANVRNKKVLKDAVNN 324

  Fly   355 LDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGVAGNTTEVFQKYNWGNGEN 419
            : ..:|..:....:..||:.|..|..||     :.||:.|||.|||......|:|.|||      
  Rat   325 I-TAKGITDYKKGFSFAFEQLLNYNVSR-----ANCNKIIMLFTDGGEERAQEIFAKYN------ 377

  Fly   420 GTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVDVIATPLVLQNEQ 484
              .....||||:.:|:.......||||||.|:|||..:.::..:.....:|:||:..|:||..::
  Rat   378 --KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDK 440

  Fly   485 HPPT-WTHAFTDKTYDPKTSNEKRPRLMISVGVPAFDRFYRHANSTNPRARL-LGVAGTDVPVED 547
            .... ||:.:.|..         ...|:|:..:|.|:...:..|.||.:.:| |||.|.||.:||
  Rat   441 AKQVQWTNVYLDAL---------ELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLED 496

  Fly   548 IDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKMNPNYN---SIDFTEVEHLFEDQSPR 609
            |.:||..:.|..|||.|.:..||||||||:|:|      .||...   ::||.:.| |..|..  
  Rat   497 IKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQP------KNPKSQEPVTLDFLDAE-LENDIK-- 552

  Fly   610 EPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFTLGIVMPSEYGK 674
                  :.|||.|:..|:.| |:..........|.:.:..:.|.:.|:..|.::|.:|:|: |..
  Rat   553 ------VEIRNKMIDGESGE-KTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPT-YSF 609

  Fly   675 TWI--KVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCKYHYLE-GHEFKTPEAELREFLAKMQ 736
            .:|  |:.|.:.:.:..|..:.|   .|..|  ||      ::.| |:.|..|    ||:.    
  Rat   610 YYIKAKIEETITQARSKKGKMKD---SETLK--PD------NFEESGYTFIAP----REYC---- 655

  Fly   737 NDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFDAKVTN---SSYGVWRFES 798
            ||.|.|:...|...::::..|    |||..:.:  ||.:|:|.::.||..||   .:|  |    
  Rat   656 NDLKPSDNNTEFLLNFNEFID----RKTPNNPS--CNTDLINRILLDAGFTNELVQNY--W---- 708

  Fly   799 DEERQLIERFRADLRFVATMSGLTR---------WQFIFGEVEVDTDREFGDYHTTAIDETWYKS 854
             .:::.|:..:|  |||.|..|:||         ||                .:....::::||.
  Rat   709 -SKQKNIKGVKA--RFVVTDGGITRVYPKEAGENWQ----------------ENPETYEDSFYKR 754

  Fly   855 AILQHHEDRAESFVYSVKYYDDPMEDS-EVKVTASHAIFPRDGGKEAPACVVGFQFSHARMWERF 918
            ::     |. :::|::..|::.....: |..:..|.|:.....||.....|||.:.. ...|...
  Rat   755 SL-----DN-DNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKID-VNSWIEN 812

  Fly   919 FNITAV-DHCNHCLPIC----TDDDVDCVVIDNNAYIVIGQN---INTTGKFFGEFHGDVMTAMV 975
            |..|:: |.|  ..|:|    ..|.:|||::|:..::::..:   .|..|:||||....:|..:|
  Rat   813 FTKTSIRDPC--AGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMRHLV 875

  Fly   976 ERGIFLSIEVYDYQEQCK--EEPKAGSDGHGLLHPLRLLSLGWKYLVGRLFFEYQRIQWWADGAP 1038
            ...::...:.||||..|.  ..||.|: ||...:...:..:             .:|.|||..|.
  Rat   876 NISLYAFNKSYDYQSVCDPGAAPKQGA-GHRSAYVPSITDI-------------LQIGWWATAAA 926

  Fly  1039 F---------------MEYTDEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDEPEPDPIYKACD 1088
            :               :|..:..||::.|       |.||                     ::|.
  Rat   927 WSILQQLLLSLTFPRLLEAVEMEEDDFTA-------SLSK---------------------QSCI 963

  Fly  1089 KRSTLYALQ--PSALVGINDFVEAPSTRPFLVKKIPNSNLVLVVVNVLMPSR-----SVRLTTEP 1146
            ...|.|..:  ..:..|:.|.  ...:|.|.|:|:.|:|||.::|.    |:     ..||..:.
  Rat   964 TEQTQYFFKNDTKSFSGLLDC--GNCSRIFHVEKLMNTNLVFIMVE----SKGTCPCDTRLLMQA 1022

  Fly  1147 QRMEYDKEFPCYKLNMSFYERRRIEECY--TVHEDEELYTYCGNASRLVLTL-QLMPLTIILVFY 1208
            ::.. |...||..:....| |:..:.|:  .|.||   ||.||..|.|..:| .:..|..||::.
  Rat  1023 EQTS-DGPDPCDMVKQPRY-RKGPDVCFDNNVLED---YTDCGGVSGLNPSLWSIFGLQFILLWL 1082

  Fly  1209 LTHS 1212
            ::.|
  Rat  1083 VSGS 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-Ma2dNP_001260486.1 VWA_N 124..251 CDD:285584 43/132 (33%)
vWA_VGCC_like 267..461 CDD:238740 65/193 (34%)
Cache_1 510..587 CDD:280839 34/77 (44%)
Cacna2d1NP_037051.2 VWA_N 104..223 CDD:285584 43/132 (33%)
vWA_VGCC_like 239..417 CDD:238740 65/193 (34%)
MIDAS-like motif 259..263 2/3 (67%)
Cache_1 446..531 CDD:280839 37/99 (37%)
VGCC_alpha2 543..627 CDD:285647 21/94 (22%)
RAMP_I_III <636..816 CDD:304371 54/233 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D237570at33208
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X365
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
66.020

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