DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-Ma2d and Cacna2d3

DIOPT Version :9

Sequence 1:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	NP_033915.1	Gene:	Cacna2d3 / 12294	MGIID:	1338890	Length:	1091	Species:	Mus musculus

Alignment Length:	1218	Identity:	378/1218 - (31%)
Similarity:	593/1218 - (48%)	Gaps:	185/1218 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LICGPHGGT-FPSTSIHWA--------EASAADEAVGKWATQFGDELFALAQKITKSQEIKEKYK 84
            |.|...|.: ..:|::.:|        |.......|..||:.||.|:.::|.|.:.||.:::|||
Mouse     7 LCCASRGASALLATALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYK 71

  Fly    85 EYNARVELK--NGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSS 147
            ||...|.::  :|.:|:|.:.|.:..|..:|.:|||.:.|.||..:...||:.          ..
Mouse    72 EYEKDVAIEEIDGLQLVKKLAKIMEEMFHKKSEAVRRLVEAAEEAHLKHEFDA----------DL 126

  Fly   148 KYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIM 212
            :|..||.....|.: .:..|..:.:...|.|:.||.|.||:...|.|.||:|::::...::..:.
Mouse   127 QYEYFNAVLINERD-KDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVY 190

  Fly   213 WSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETAT 277
            |||.|::||..|:..||:|.||||||..|..|.||..:|   .|:.:....:|||.|.|||:.||
Mouse   191 WSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKW---EPDENGVIAFDCRNRKWYIQAAT 252

  Fly   278 CSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGALVQATP 342
            ..||:|||:|.||||.|.|..:||.|:.|||||..::|||.|:.|:.|::.:.||.||.||||..
Mouse   253 SPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADR 317

  Fly   343 ENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGVAGNTTE 407
            .|.|.|.:.:::| ..:|...|.:|...||.:|.   |..|....|.|:|||||:|||.......
Mouse   318 TNKEHFREHLDKL-FAKGIGMLDIALNEAFNILS---DFNHTGQGSICSQAIMLITDGAVDTYDT 378

  Fly   408 VFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVD 472
            :|.||||.:.:       .|:||||:|:|......::||||.|:|:::.:.||.:|.|.|::|:.
Mouse   379 IFAKYNWPDRK-------VRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLH 436

  Fly   473 VIATPLVLQNEQHPPTWTHAFTDKTYD--PKTSNEKRPRLMISVGVPAFDRFYRHANSTNPRARL 535
            |::.|.|: :::|...||.|:.|.|..  .|.::::...||.:|.:|.|.:    .|.|..:..|
Mouse   437 VLSRPKVI-DQEHDVVWTEAYIDSTLPQAQKLADDQGLVLMTTVAMPVFSK----QNETRSKGIL 496

  Fly   536 LGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGK--MNPNYNSIDFTE 598
            |||.||||||:::.|....||||::||:|.::||||:|.||:|||:...||  ..|||:|:|.:|
Mouse   497 LGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSE 561

  Fly   599 VEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFT 663
            ||  :||:      :.:|  |||||..:..:| |:.||...||.:||.....||::..:..|||:
Mouse   562 VE--WEDR------DDVL--RNAMVNRKTGKF-SMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFS 615

  Fly   664 LGIVMPSEYGKTW----IKVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCKYHYLEGHEFKTP 724
            ||:.:...:||.:    :.:.|.:...:|..::::|           :|.||.......|...:.
Mouse   616 LGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLAD-----------EWSYCNTDLHPEHRHLSQ 669

  Fly   725 EAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFDAKVTNS 789
            ...::.:|.                           |::.|    ..|:|||:..::|||.|:..
Mouse   670 LEAIKLYLK---------------------------GKEPL----LQCDKELIQEVLFDAVVSAP 703

  Fly   790 SYGVW------RFESDEERQLIERFRADLRFVATMSGLTRWQFIFGEVEVDTDREF---GDYHTT 845
            ....|      :.|:.::       ..::.|:.|.:||:|.....|..:: |:::|   ||....
Mouse   704 IEAYWTSLALNKSENSDK-------GVEVAFLGTRTGLSRINLFVGAEQL-TNQDFLKAGDKENI 760

  Fly   846 AIDE---TWYKSAILQHHEDRAESFVYSVKYYDDPMEDSEVKVTASHAIFPRDGGKEAPACVVGF 907
            ...:   .||:.|.    |..|.|||||:.:....:..|.| ||||.:|...|..|......||.
Mouse   761 FNADHFPLWYRRAA----EQIAGSFVYSIPFSTGTVNKSNV-VTASTSIQLLDERKSPVVAAVGI 820

  Fly   908 Q----FSHARMWERFFNITAVDHC----NHCLPICTDDDVDCVVIDNNAYIVIGQNINTTGKFFG 964
            |    |...:.|      ||...|    ..|...|.|:.|:|.:||||.:|::.::...||.|||
Mouse   821 QMKLEFFQRKFW------TASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFG 879

  Fly   965 EFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPLRLLSLGWKYLVGRL---FFE 1026
            |..|.||..::..|.|..|.:||||..|:...::....||||.|.:......|:::..|   ..|
Mouse   880 EVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIMTELVLFLVE 944

  Fly  1027 YQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDEPEPDPIYKACDKRS 1091
            :....||        ::|.            .:.|.|.|...          ||      ||...
Mouse   945 FNLCSWW--------HSDM------------TAKAQKLKQTL----------EP------CDTEY 973

  Fly  1092 TLYALQPSALVGINDFVEAPSTRPFLVKKIPNSNLVLVVVNVLMPSRSVR-LTTEPQRMEYDKEF 1155
            ..:..:.:......:......::.|::::||:|||.:|||:......||. :|..|..:.|::..
Mouse   974 PAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESL 1038

  Fly  1156 PCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRL--VLTLQLMPL 1201
            .|.:|..... |||.|.|:..|.:|.. ..||.||.|  ...|.|:||
Mouse  1039 KCERLKAQKI-RRRPESCHGFHPEENA-RECGGASSLQAQAALLLLPL 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	41/126 (33%)
		vWA_VGCC_like	267..461	CDD:238740	82/193 (42%)
		Cache_1	510..587	CDD:280839	37/78 (47%)
Cacna2d3	NP_033915.1	VWA_N	113..229	CDD:285584	41/126 (33%)
		vWA_VGCC_like	242..425	CDD:238740	82/193 (42%)
		MIDAS-like motif	262..266		2/3 (67%)
		Cache_1	452..548	CDD:280839	42/99 (42%)
		VGCC_alpha2	561..633	CDD:285647	28/82 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I4177
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm8846
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.770