DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-Ma2d and Cacna2d1

DIOPT Version :9

Sequence 1:NP_001260486.1 Gene:Ca-Ma2d / 34951 FlyBaseID:FBgn0261999 Length:1215 Species:Drosophila melanogaster
Sequence 2:XP_011248046.1 Gene:Cacna2d1 / 12293 MGIID:88295 Length:1110 Species:Mus musculus


Alignment Length:1279 Identity:342/1279 - (26%)
Similarity:570/1279 - (44%) Gaps:260/1279 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 AVILTAFSFSQPLLLLLICGPHG-GTFPSTSIHWAEASAADEAVGKWATQFGDELFALAQK---I 73
            |:.||.|...       :.||.. ..|||           ...:..|..:..::|..||:.   :
Mouse     8 ALTLTLFQSG-------LIGPSSEEPFPS-----------PVTIKSWVDKMQEDLVTLAKTASGV 54

  Fly    74 TKSQEIKEKYKEYNARVELKNGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYA 138
            |:..:|.|||::... ||..|..:|::...:::.::|:.:..|:..:...||.|....::...:|
Mouse    55 TQLADIYEKYQDLYT-VEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFA 118

  Fly   139 LQNFTYFSSKYSTFNGNSSEELEP--NEAEFAWMYRNMELNP----DTHFYNTPVDTEHSSVHVP 197
            .....|:         |:.::|:|  ||:|..    :..:.|    |.:| ...:..:|::||:|
Mouse   119 SNEVVYY---------NAKDDLDPERNESEPG----SQRIKPVFIEDANF-GRQISYQHAAVHIP 169

  Fly   198 SNIWDRSERVLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDAD 262
            ::|::.|..||..:.|:..|||||::|...||.|.||.|||.||:.|:|||:.|.|.....:..|
Mouse   170 TDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKID 234

  Fly   263 TYDCRKRSWYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVN 327
            .||.|:|.|||:.|...||::||:|.|||::|....:.:.::..:|:|.|::||..:..::|...
Mouse   235 LYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQ 299

  Fly   328 DIIPCFNGALVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQ 392
            | :.||. .||||...|.:|....:..: ..:|..:....:..||:.|..|..||     :.||:
Mouse   300 D-VSCFQ-HLVQANVRNKKVLKDAVNNI-TAKGITDYKKGFSFAFEQLLNYNVSR-----ANCNK 356

  Fly   393 AIMLVTDGVAGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHV 457
            .|||.|||......|:|.|||        .....||||:.:|:.......||||||.|:|||..:
Mouse   357 IIMLFTDGGEERAQEIFAKYN--------KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEI 413

  Fly   458 QTLDEVHEEVLKYVDVIATPLVLQNEQHPPT-WTHAFTDKTYDPKTSNEKRPRLMISVGVPAFDR 521
            .::..:.....:|:||:..|:||..::.... ||:.:.|..         ...|:|:..:|.|:.
Mouse   414 PSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDAL---------ELGLVITGTLPVFNV 469

  Fly   522 FYRHANSTNPRARL-LGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDL--RPIGT 583
            ..:..|.||.:.:| |||.|.||.:|||.:||..:.|..|||.|.:..||||||||:|  :|||.
Mouse   470 TGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGV 534

  Fly   584 N------GKMNPNYN--------SIDFTEVEHLFEDQSPREPGESILHIRNAMVRHEANEFKSIS 634
            .      .|..||..        ::||.:.|  .|:       |..:.|||.|:..|:.| |:..
Mouse   535 GIPTINLRKRRPNVQNPKSQEPVTLDFLDAE--LEN-------EIKVEIRNKMIDGESGE-KTFR 589

  Fly   635 VKFHYDKMRRVSEEKQDYFFAPLPNTPFTLGIVMPSEYGKTWI--KVGEEVDKNKHMKINISDFF 697
            ........|.:.:..:.|.:.|:..|.::|.:|:|: |...:|  |:.|.:.:.:..|..:.|  
Mouse   590 TLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPT-YSFYYIKAKLEETITQARSKKGKMKD-- 651

  Fly   698 IGENWKVHPDWVYCKYHYLE-GHEFKTPEAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCG 761
             .|..|  ||      ::.| |:.|..|    ||:.    ||.|.|:...|...::::..|    
Mouse   652 -SETLK--PD------NFEESGYTFIAP----REYC----NDLKPSDNNTEFLLNFNEFID---- 695

  Fly   762 RKTLGDDAYYCNKELVNLLIFDAKVTN---SSYGVWRFESDEERQLIERFRADLRFVATMSGLTR 823
            |||..:.:  ||.:|:|.::.||..||   .:|  |     .:::.|:..:|  |||.|..|:||
Mouse   696 RKTPNNPS--CNTDLINRILLDAGFTNELVQNY--W-----SKQKNIKGVKA--RFVVTDGGITR 749

  Fly   824 ---------WQFIFGEVEVDTDREFGDYHTTAIDETWYKSAILQHHEDRAESFVYSVKYYDDPME 879
                     ||                .:....::::||.::     |. :::|::..|::....
Mouse   750 VYPKEAGENWQ----------------ENPETYEDSFYKRSL-----DN-DNYVFTAPYFNKSGP 792

  Fly   880 DS-EVKVTASHAIFPRDGGKEAPACVVGFQFSHARMWERFFNITAV-DHCNHCLPIC----TDDD 938
            .: |..:..|.|:.....||.....|||.:.. ...|...|..|:: |.|  ..|:|    ..|.
Mouse   793 GAYESGIMVSKAVELYIQGKLLKPAVVGIKID-VNSWIENFTKTSIRDPC--AGPVCDCKRNSDV 854

  Fly   939 VDCVVIDNNAYIVIGQN---INTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCK--EEPKA 998
            :|||::|:..::::..:   .|..|:||||....:|..:|...::...:.||||..|.  ..||.
Mouse   855 MDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQ 919

  Fly   999 GSDGHGLLHPLRLLSLGWKYLVGRLFFEYQRIQWWADGAPF---------------MEYTDEIED 1048
            |: ||...:...:..:             .:|.|||..|.:               :|..:..||
Mouse   920 GA-GHRSAYVPSIADI-------------LQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEED 970

  Fly  1049 EYVAVGDGGKSSASKPKDDSDDENAMFDEPEPDPIYKACDKRSTLYALQ--PSALVGINDFVEAP 1111
            ::.|       |.||                     ::|....|.|..:  ..:..|:.|.  ..
Mouse   971 DFTA-------SLSK---------------------QSCITEQTQYFFKNDTKSFSGLLDC--GN 1005

  Fly  1112 STRPFLVKKIPNSNLVLVVVNVLMPSR-----SVRLTTEPQRMEYDKEFPCYKLNMSFYERRRIE 1171
            .:|.|.|:|:.|:|||.::|.    |:     ..||..:.::.. |...||..:....| |:..:
Mouse  1006 CSRIFHVEKLMNTNLVFIMVE----SKGTCPCDTRLLMQAEQTS-DGPDPCDMVKQPRY-RKGPD 1064

  Fly  1172 ECY--TVHEDEELYTYCGNASRLVLTL-QLMPLTIILVFYLTHS 1212
            .|:  .|.||   ||.||..|.|..:| .:..|..||::.::.|
Mouse  1065 VCFDNNVLED---YTDCGGVSGLNPSLWSIFGLQFILLWLVSGS 1105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-Ma2dNP_001260486.1 VWA_N 124..251 CDD:285584 43/132 (33%)
vWA_VGCC_like 267..461 CDD:238740 65/193 (34%)
Cache_1 510..587 CDD:280839 36/85 (42%)
Cacna2d1XP_011248046.1 VWA_N 104..223 CDD:369855 43/132 (33%)
vWA_VGCC_like 239..417 CDD:238740 65/193 (34%)
dCache_1 <437..622 CDD:376917 59/203 (29%)
VGCC_alpha2 651..1079 CDD:369894 124/539 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2353
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X365
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.910

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