Protein Alignment Ca-Ma2d and cacna2d1

DIOPT Version :9

• Sequence 1: NP_001260486.1
• Gene: Ca-Ma2d / 34951
• FlyBaseID: FBgn0261999
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: XP_017207543.2
• Gene: cacna2d1 / 101882457
• -ID: -
• Length: 1094
• Species: Danio rerio
• Alignment Length: 1197
• Identity: 312/1197 - (26%)
• Similarity: 541/1197 - (45%)
• Gaps: 192/1197 - (16%)

  Fly    55 VGKWATQFGDELFALAQKITKSQEIKEKY--KEYNARVELKNGTELIKSITKNVGRMLARKMDAV 117
            :.:|..|...||.:||...:....:::.:  .:.:..|...|..:|:::..:|:...|.::..|:
Zfish    42 IKEWVDQLQQELVSLADTASAGDNLRQIFMDNQKSFTVRSNNAVQLVETAARNIENFLKKRATAL 106

  Fly   118 RCIQERAEYVNENFEFNLTYALQNFTYFSSKYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHF 182
            ..:...||......::...:|..:..||         |:.:.||.|:.|........|...|..|
Zfish   107 ETLATAAENFQMEHQWKDEFAEDDIVYF---------NAKDNLETNDTEGRKNRIRPEFKEDPSF 162

  Fly   183 YNTPVDTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYP 247
            .|......|::||:|::|:|.|..||..:.|:|.|::||::|.:.||.|.||.|||.||:.|.||
Zfish   163 KNRLTSYNHTAVHIPTDIYDGSTIVLNELNWTEALEDVFKKNREEDPTLLWQVFGSATGLARFYP 227

  Fly   248 AAQWTDTRPNRDDADTYDCRKRSWYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFS 312
            |:.|.|.|......|.||.|:|.||::.|...||::||:|.|||::|....:.:.::..:|:|.|
Zfish   228 ASPWMDARKTPSKIDLYDVRRRPWYVQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLS 292

  Fly   313 NNDFFTILRYSSEVNDIIPCFNGALVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRK 377
            ::|:..::.::::||: ..||: .||||...|.::....::.: ..:|..|.|..:|.||..|
Zfish   293 DDDYVNVVHFNTKVNN-TACFD-HLVQANVRNKKILKDAVQNI-TAKGITNYTKGFEFAFNQL-- 352

  Fly   378 YYDSRHCVTNSTCNQAIMLVTDGVAGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVRE 442
               |...::.:.||:.|||.|||......|:|.::|        .....||||:.:|:.......
Zfish   353 ---SNPNISRANCNKIIMLFTDGGEERAEEIFSRHN--------IDRKVRVFTFSVGQHNYDTGP 406

  Fly   443 IQWMACLNRGYYSHVQTLDEVHEEVLKYVDVIATPLVLQNEQHPPTWTHAFTDKTYDPKTSNEKR 507
            |:||||.|:||:..:.::..:.....:|:||:..|:||.:.:. ..||:.:.|..         .
Zfish   407 IKWMACQNKGYFYEIPSIGAIRINTQEYLDVLGRPMVLADAKQ-VQWTNVYLDAL---------E 461

  Fly   508 PRLMISVGVPAFDRFYRHANSTNPRAR-----LLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVS 567
            ..|:|:..:|.|::    ..||..|:|     :|||.|.||.::||.:||..:.:|.|||.|.:.
Zfish   462 LGLVITGTLPVFNK----TKSTEARSRSQNQLILGVMGVDVSLDDIKRLTPRFTIGPNGYYFAID 522

  Fly   568 NNGYVLLHPDLRPIGTNGKMNPNYN---SIDFTEVEHLFEDQSPREPGESILHIRNAMVRHEANE 629
            .||||||||:|:|      .||.:.   ::||.:.| |..|..        :.||..|:.:.:.|
Zfish   523 PNGYVLLHPNLQP------KNPKFQEPVTLDFLDAE-LENDIK--------VQIRTMMINNSSGE 572

  Fly   630 FKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFTLGIVMPSEYGKTWIKVGEEVDKNKHMKINIS 694
             |:|.........|.:....:.|.:||:..|.::|.:|:| ||...:|:.            |:.
Zfish   573 -KTIETLVKSQDERYIDRGIRKYTWAPVNGTDYSLALVLP-EYSLHYIEA------------NLG 623

  Fly   695 DFF--IGENW--KVHPDWVYCKYHYLEGHEFKTPEAELREFLAKMQNDWKWSEQYAEDESDWDDK 755
            |..  :...|  ||.......|:... |:.|..|....::......|     .|:..|.:::.:|
Zfish   624 DTIKQVMSQWGNKVFETIQQEKFEEF-GYTFIAPREYCKDLKVSSNN-----TQFLMDFNEYINK 682

  Fly   756 DDLNCGRKTLGDDAYYCNKELVNLLIFDAKVTNSSYGVWRFESDEERQLIERFRADLRFVATMSG 820
                   :|..|..  ||..|||.::.||.:|.....||:      .|.::...|  |||||..|
Zfish   683 -------QTPNDPT--CNYTLVNRMLLDAGLTAKLIKVWK------EQSVDGVLA--RFVATDGG 730

  Fly   821 LTRWQFIFGEVEVDTDREFGDYHTTAIDETWYKSAILQHHEDRAESFVYSVKYYDDPMEDS-EVK 884
            :||   ::.:   ....|:|: ::...|.::||.::     |. :.::::..|.:...|.. |..
Zfish   731 ITR---VYPK---SAGEEWGE-NSETYDSSFYKRSL-----DN-DIYIFTAPYVNKSRESGYESG 782

  Fly   885 VTASHAI-FPRDGGKEAPACVVGFQFSHARMWERFFNITAVDHCNH--CLPICTDDDVDCVVIDN 946
            :..|.|: ...||.|..|| |||.:.:.:.....|.|.|...:|..  |..:..|..||||::|:
Zfish   783 ILVSKAVDLDIDGAKLKPA-VVGVKLNVSAWMNSFINATTKKNCKDEICGCLRNDKQVDCVILDD 846

  Fly   947 NAYIVIG---QNINTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQC--KEEPKAGSDGHGLL 1006
            ..::::.   :.|...|:||||....:|..:|...::...:.||||..|  :.|.||.: ||..:
Zfish   847 GGFLLMSNQEEYIQQIGQFFGEVDPVLMITLVNTSLYSFNKTYDYQSVCDPERETKAAA-GHRAI 910

  Fly  1007 HP---LRLLSLGWKYLVGRLFFEYQRIQWWADGAPF---------MEYTDEIEDEYVAVGDGGKS 1059
            :.   ..||::|                |||..|.:         :...:.|...|
Zfish   911 YVPTIADLLTVG----------------WWASTAVWSILQQLLLSLTLPNVIGTVY--------- 950

  Fly  1060 SASKPKDDSDDENAMFDEPEPDPIYKACDKRSTLYAL--QPSALVGINDFVEAPSTRPFLVKKIP 1122
                   ..||.:..|.:       ::|....|.|..  :..:..|..|.  ...:|.:..:|:|
Zfish   951 -------SEDDLSDAFSK-------ESCITEQTQYFFENENKSFSGAMDC--GNCSRMYRAEKLP 999

  Fly  1123 NSNLVLVVVNVLMPSRSVRLTTEPQRMEYDKE---FPCYKLNMSFYERRRIEECYTVHEDEELYT 1184
            |:|||.::.:..:...|  ..|:|.:......   .||.......| |:..:.|:..:.||:. :
Zfish  1000 NTNLVFLISDAKISCMS--CDTKPLKQAEQPSNGPDPCVLAQKPRY-RKGPDVCFDNNADEDA-S 1060

  Fly  1185 YCGNASRLVLTL-QLMPLTIILVFYLT 1210
            .||..|.|..:| .::.|.::|::.||
Zfish  1061 DCGGGSSLSPSLWPMLALQLLLLWLLT 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	43/126 (34%)
		vWA_VGCC_like	267..461	CDD:238740	59/193 (31%)
		Cache_1	510..587	CDD:280839	33/81 (41%)
cacna2d1	XP_017207543.2	VWA_N	119..231	CDD:312040	41/120 (34%)
		vWFA	247..425	CDD:320736	59/193 (31%)
		dCache_1	<490..609	CDD:308398	44/134 (33%)
		VGCC_alpha2	638..1025	CDD:312092	105/467 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8115
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237570at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.020