DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-Ma2d and cacna2d3a

DIOPT Version :9

Sequence 1:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_009302617.1	Gene:	cacna2d3a / 100535196	ZFINID:	ZDB-GENE-060328-4	Length:	1080	Species:	Danio rerio

Alignment Length:	1230	Identity:	373/1230 - (30%)
Similarity:	575/1230 - (46%)	Gaps:	199/1230 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FSQPLLLLL-------ICGPHGGTFPSTSIHWAEASAADEAVGKWATQFGDELFALAQKITKSQE 78
            |.:..:|||       ||..|.| .|.:            .|..||:.||.|:.::|.|.:.||.
Zfish     5 FCRLFVLLLWIINDSGICASHQG-IPLS------------VVKLWASAFGGEIKSIAAKYSGSQL 56

  Fly    79 IKEKYKEY--NARVELKNGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQN 141
            :::||||:  :.|||..:|.:|:|.:...:.:...:|.:|::.:.|.||..:.|.|.:.
Zfish    57 LQKKYKEFERSVRVEEIDGIKLVKKLAAKMEQRFHKKAEAIKRLVEAAEEAHLNHEEDP------ 115

  Fly   142 FTYFSSKYSTFNGNSSEELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSER 206
                ..:|..||.....||: .|.....:.....|.|:.||.|..|:...|.|.||:|::::...
Zfish   116 ----DLQYEYFNAVLINELD-EEGRSVELGGEFILQPNEHFNNLSVNLSLSVVQVPTNMYNKDSD 175

  Fly   207 VLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSW 271
            ::..:.|||.|:.||..|::.||:|.||||||..|..|.||..:||   |:......:|||.|.|
Zfish   176 IVNGVYWSEALNTVFVDNFKRDPSLLWQYFGSAQGFFRQYPGMKWT---PDEHGVLEFDCRNRKW 237

  Fly   272 YIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGA 336
            ||:.||..||:|||:|.||||.|.|..:|:.|:.|||||..::|||.::.|:.:::.:.||.||.
Zfish   238 YIQAATSPKDVVILVDVSGSMKGLRLTIARQTVSSILDTLGDDDFFNVIAYNEDLHYVEPCLNGT 302

  Fly   337 LVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGV 401
            ||||...|.:.|.|::::| ..:|...|.:|...||:||..:..:..   .|.|:|||||||||.
Zfish   303 LVQADITNKDHFRQRLDKL-LAKGIGMLDVALTEAFELLSNFNQTGR---GSECSQAIMLVTDGA 363

  Fly   402 AGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEE 466
            ......||..|||.:.:       .|||.||:|:|......::||||.|:||::.:.||.:|.|.
Zfish   364 VETYDAVFAVYNWPDRK-------VRVFPYLIGRESAFADNLKWMACANKGYFTQISTLADVQEN 421

  Fly   467 VLKYVDVIATPLVLQNEQHPPTWTHAFTDKTYD--PKTSNEKRPRLMISVGVPAFDRFYRHANST 529
            |:||:.|::.|.|:..| |...||.|:.|.|..  .|..:.:.|.||.:|.:|.|..    .|.|
Zfish   422 VMKYLHVLSRPKVIDRE-HDMVWTEAYIDNTRSQAQKLEDAQGPVLMTTVAMPVFST----KNET 481

  Fly   530 NPRARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGK--MNPNYN 592
            ..:..||||.||||||.:|.|....||||::||:|.::||||:|.||||:|:...||  ...:|:
Zfish   482 RNKGILLGVVGTDVPVSEILKAIPKYKLGIHGYAFAITNNGYILTHPDLQPLYEEGKKRRKSSYS 546

  Fly   593 SIDFTEVEHLFEDQSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPL 657
            |.|.:|||  :||:..        .:|||||..:...| |:.||...||.:||.....||::..:
Zfish   547 SADLSEVE--WEDKED--------ELRNAMVNRQTGSF-SMKVKKTVDKGKRVLVLHNDYYYTDI 600

  Fly   658 PNTPFTLGIVMPSEYGKTW----IKVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCKYHYLEG 718
            ..|||:||:.:...:||..    |.|.|.:...:|..:.::|           :|.||.......
Zfish   601 KGTPFSLGVALSGGHGKYVFRGNISVEEGLHDLEHPDVALAD-----------EWTYCNTEEHPD 654

  Fly   719 HEFKTPEAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFD 783
            |    |.....|.:....|                            |::...|::|||..::||
Zfish   655 H----PVLSQIEAIKLYFN----------------------------GEEHLKCDQELVQEVLFD 687

  Fly   784 AKVTNSSYGVW------RFESDEERQLIERFRADLRFVATMSGLTRWQ------------FIFGE 830
            |.||......|      :.|:.::       ..::.|:||.:||:|..            .:.||
Zfish   688 AVVTAPLEAYWTSLALNKSENSDK-------GVEISFLATRTGLSRINLFVTPDQLSNQGLLTGE 745

  Fly   831 VEVDTDREFGDYHTTAIDETWYKSAILQHHEDRAESFVYSVKYYDDPMEDSEVKVTASHAIFPRD 895
               |.:.:|...|.    ..||:.|.    |....:||||:.|  |...|::..|.||.||...|
Zfish   746 ---DKEVQFSADHF----PLWYRRAA----EQVPGTFVYSLPY--DAASDNKSVVLASSAIHLLD 797

  Fly   896 GGKEAPACVVGFQ----FSHARMWERFFNITAVDHCNHCLPICTDDDVDCVVIDNNAYIVIGQNI 956
            ..:...|..||.|    |...:.|.......|:|  ..|...|.:||:.|.:||||.:|::.::.
Zfish   798 ERESPIAAAVGIQMKLEFFQRKFWTASRQCAALD--GKCSISCDNDDISCYLIDNNGFIIVAEDQ 860

  Fly   957 NTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPLRLLSLGWKYLVG 1021
            :.||.||||..|.||..:|..|.|..:.:|||:..|:...:.....|.||||...|....::|:.
Zfish   861 SLTGVFFGEPEGAVMGKLVSMGSFKRVNLYDYRAICRVYAQTSDTAHTLLHPYFALFAAIRWLLT 925

  Fly  1022 R---LFFEYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDEPEPDPI 1083
            .   ...|:....||.            .|..:....||::                       :
Zfish   926 EFVIFLVEFNLYSWWH------------SDLTITAHRGGRT-----------------------L 955

  Fly  1084 YKACDKRSTLYALQPSALVGINDFVEAPSTRPFLVKKIPNSNLVLVVV-NVLMPSRSVRLTTEPQ 1147
            ...||.....:..:.:....:.:.......:.|::::||:|||.:||: |....|....:|.||.
Zfish   956 LVPCDTEYPAFVSERTIKETVGNIDCESCVKSFVIQQIPSSNLFMVVIDNTCDCSDFGPVTMEPV 1020

  Fly  1148 RMEYDKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRLVLTLQLMPLTIILVF 1207
            .:.|::...|.:|... .:|||.:.|:..|.:|.... ||.:..|..:...:.:.||.:|
Zfish  1021 EIMYNESLKCERLKFQ-KDRRRPDTCHPFHHEENSME-CGGSVSLSPSSPALLVLIISIF 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	41/126 (33%)
		vWA_VGCC_like	267..461	CDD:238740	80/193 (41%)
		Cache_1	510..587	CDD:280839	38/78 (49%)
cacna2d3a	XP_009302617.1	SPEC	<52..>103	CDD:295325	14/50 (28%)
		VWA_N	104..220	CDD:285584	41/126 (33%)
		vWA_VGCC_like	233..416	CDD:238740	80/193 (41%)
		Cache_1	443..539	CDD:280839	44/99 (44%)
		VGCC_alpha2	552..625	CDD:285647	27/83 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4523
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm6553
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.910