Protein Alignment Ca-Ma2d and cacna2d4

DIOPT Version :10

• Sequence 1: NP_723955.2
• Gene: Ca-Ma2d / 34951
• FlyBaseID: FBgn0261999
• Length: 1215
• Species: Drosophila melanogaster
• Sequence 2: XP_031754464.1
• Gene: cacna2d4 / 100488361
• XenbaseID: XB-GENE-991123
• Length: 1121
• Species: Xenopus tropicalis
• Alignment Length: 1238
• Identity: 375/1238 - (30%)
• Similarity: 590/1238 - (47%)
• Gaps: 217/1238 - (17%)

  Fly    46 AEASAADEAVGKWATQFGDELFALAQKITKSQEIKEKYK--EYNARVELKNGTELIKSITKNVGR 108
            |:...:.:.|..||..||.|:::|..:.:.|..:::|||  |....:|..:|.||:|..::.:..
 Frog    17 AQNQISTDTVKIWADAFGGEVYSLVTRYSGSLLLQKKYKDVEPTLSIEEVDGLELVKKFSEEMEN 81

  Fly   109 MLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSSKYSTFNGNSSEELEPNE------AEF 167
            ||.||::||..:.|.||..:.:.|||.          |.::..:|.....|.:.|:      :||
 Frog    82 MLRRKVEAVEKLVEAAEDADLHHEFNT----------SLEFEYYNSVRINEKDENDNYVELGSEF 136

  Fly   168 AWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVFRQNYQSDPALS 232
            .       |..:.||.|..|:|..|::.:|:|::::...:|..:..||.|:.:|..|:|.||.|:
 Frog   137 I-------LETNEHFNNLMVNTSLSNIQLPTNVYNKDPSILNGVYMSEALNPIFVDNFQRDPTLT 194

  Fly   233 WQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETATCSKDIVILLDHSGSMTGFRH 297
            ||||||.:|..|.||..:|.   |:.:...::|||.|.|||:.||..|||||::|.||||.|.|.
 Frog   195 WQYFGSSSGFFRLYPGIKWV---PDENGVISFDCRNRGWYIQAATSPKDIVIVVDISGSMKGLRM 256

  Fly   298 HVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGALVQATPENIEVFNQQIEQLDDPEGYA 362
            .:||.||.::|||...|||..|:.|:..|:.|.|||.|.||||..:|.|.|.|.:::| ..:|..
 Frog   257 TIAKHTISTLLDTLGENDFVNIIAYNDYVHYIEPCFKGILVQADRDNREHFKQLVDEL-HAKGVG 320

  Fly   363 NLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGVAGNTTEVFQKYNWGNGENGTSQMDTR 427
            .:..|...||::|:::   |.......|||||||:|||.......||:|||:.:.:       .|
 Frog   321 TVNKALIEAFKILKEF---REAGQGGLCNQAIMLITDGAVEEYEPVFEKYNFPDRK-------VR 375

  Fly   428 VFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVDVIATPLVLQNEQHPPTWTHA 492
            :||||:|:|||....::|:||.|:|||:.:.||.:|.|.|::|:.|::.|:|: |..|...||.|
 Frog   376 LFTYLIGREVTFSSNVKWIACNNKGYYTQISTLADVQENVMEYLHVLSRPMVI-NHDHDIIWTEA 439

  Fly   493 FTDKTYDPKT-----SNEKRPRLMISVGVPAFDRFYRHANSTNPRARLLGVAGTDVPVEDIDKLT 552
            :.|... |::     |..:...||.:|.:|.|.:    .|.|.....||||.|:|||:.::.||.
 Frog   440 YMDSAL-PQSEELFASQAQSLLLMTTVAMPVFSK----KNETRSEGILLGVVGSDVPLRELLKLA 499

  Fly   553 LPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKM---NPNYNSIDFTEVEHLFEDQSPREPGES 614
            ..|||||:||:|:.:||||:|.||||||:...||.   .|||||:|.:|||  :||:      :.
 Frog   500 PRYKLGVHGYAFLNTNNGYILSHPDLRPLYKEGKKLRPKPNYNSVDLSEVE--WEDK------DE 556

  Fly   615 ILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFTLGIVMPSEYGKTWIKV 679
            ||  |.||:..|.... ::.||...||.:||.....|||:..:.:|||:||:|:...:|: :|.:
 Frog   557 IL--RTAMINGETGSL-TMDVKVPVDKGKRVLFLTSDYFYTHIDDTPFSLGVVLSRGHGE-YILI 617

  Fly   680 GEEVDKNKHMKINISDFFIGENWKVHPD------WVYCKYHYLEGHEFKTPEAELREFLAKMQND 738
            |     |...:..:.|.       :|||      |:||.......|...:....:::||.
 Frog   618 G-----NTSAEEGLHDL-------LHPDLTVANEWIYCVTDIDPDHRKLSQLQAVKKFLT----- 665

  Fly   739 WKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFDAKVTNSSYGVW-----RFES 798
                   .||       .||.            |::||:..::|||.||......|     ...|
 Frog   666 -------GED-------PDLE------------CDEELLQEVLFDAVVTAPLEAYWTQLALNMSS 704

  Fly   799 DEERQLIERFRADLRFVATMSGLTRWQFIFGEVEVDTDREFGDYHTT----AIDE--TWYKSAIL 857
            .:|       ..::.|:.|.:||.|.....|..:: |:::|..|...    .:|.  .||:.|.
 Frog   705 KDE-------GIEVAFLGTRAGLMRKNQFVGNEKL-TNKKFLQYEDKESIFTMDHFPLWYRRAA- 760

  Fly   858 QHHEDRAESFVYSVKYYDDP---MEDSEVK-----------------------VTASHAIFPRDG 896
               |..|.||||.:...|:|   ..|:::.                       ||.|.||.....
 Frog   761 ---EHPAGSFVYHIPTDDNPDHNPSDNDISEPPGQPLGSDEQSNKELGRRLEVVTVSTAISVTVH 822

  Fly   897 GKEAPACVVGFQFS----HARMWERFFNITAVDHCNH----CLPICTDDDVDCVVIDNNAYIVIG 953
            .|.|.|..:|.|..    .:..|:........| |.:    |...|.|:.:.|.::|||.:|||.
 Frog   823 SKTAIAAAIGVQMKLSLLESVFWKTMRQPNDTD-CRNVEGLCPLSCQDETLQCYLVDNNGFIVIA 886

  Fly   954 QNINTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPLRLLSLGWKY 1018
            ::.:.||.|.||..|.:::.::..|:|..:::||||..||......|....||:||..|....::
 Frog   887 KDQDKTGVFLGEVEGSLISQLLNMGVFRQVKLYDYQAMCKHPYHYHSGARNLLNPLVALMSAAQW 951

  Fly  1019 LVGRL---FFEYQRIQWWADGAPFMEYTDEIEDEYVAVGDGGKSSASKPKDDSDDENAMFDEPEP 1080
            .:|.|   |.|:....:||            .|..|........|....|.|
 Frog   952 FIGNLVLFFLEFSLCPFWA------------SDNTVQAKSFFHHSHKHKKHD------------- 991

  Fly  1081 DPIYKACDKRSTLYALQPSALVGINDFVE-APSTRPFLVKKIPNSNLVLVVVNV-----LMPSRS 1139
              :.:.||.....: :..:::...|..:. ....:.|:::::.||||:|:|.:.     ..|..|
 Frog   992 --MLQPCDTEYPAF-IHEASIQEANGLINCGECQKMFVLQQVMNSNLLLLVTDATCDCSTFPPVS 1053

  Fly  1140 VRLTTEPQRMEYDKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRLVLTLQLM--PLT 1202
            :|    .:.::|:....|.::. |...|||.:.|:..|.:|.... ||..|.:..||.|:  .||
 Frog  1054 LR----AKEVKYNASVKCDRMR-SQKLRRRPQSCHAFHPEENAQD-CGGVSGITPTLTLLFAALT 1112

  Fly  1203 IIL 1205
            :.|
 Frog  1113 VSL 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_723955.2	VWA_N	124..251	CDD:462464	40/132 (30%)
		vWA_VGCC_like	267..461	CDD:238740	84/193 (44%)
		HK_sensor	547..669	CDD:365792	55/124 (44%)
		VGCC_alpha2	772..>999	CDD:462488	70/271 (26%)
cacna2d4	XP_031754464.1	VWA_N	97..213	CDD:462464	40/132 (30%)
		vWA_VGCC_like	226..409	CDD:238740	84/193 (44%)
		HK_sensor	<433..492	CDD:365792	20/63 (32%)
		PDC2_MCP_like	494..609	CDD:350337	55/125 (44%)
		VGCC_alpha2	670..1095	CDD:462488	111/483 (23%)