DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-Ma2d and cacna2d4b

DIOPT Version :9

Sequence 1:	NP_001260486.1	Gene:	Ca-Ma2d / 34951	FlyBaseID:	FBgn0261999	Length:	1215	Species:	Drosophila melanogaster
Sequence 2:	XP_009296274.2	Gene:	cacna2d4b / 100150428	ZFINID:	ZDB-GENE-100422-18	Length:	1100	Species:	Danio rerio

Alignment Length:	1239	Identity:	367/1239 - (29%)
Similarity:	577/1239 - (46%)	Gaps:	238/1239 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TFPSTSIHW------AEASAADEAVGKWATQFGDELFALAQKITKSQEIKEKYKEYN--ARVELK 93
            ||...|..|      |:.....|.|.|||....:::.|:|.|.:.:...::|.|:..  .|:|..
Zfish    11 TFLLLSTGWMCMFTHAQMKIPPETVQKWALTISEQINAIASKYSGAALFQKKLKDVEPIIRIEDL 75

  Fly    94 NGTELIKSITKNVGRMLARKMDAVRCIQERAEYVNENFEFNLTYALQNFTYFSSKYSTFNGNSSE 158
            :|:||:....:.:.|||..||.:.:.:.:.||..:...|||  .:|| |.||::...    |:.:
Zfish    76 DGSELVLEFAEEIERMLGSKMRSAKRLADTAEDADLYHEFN--SSLQ-FDYFNALLV----NTMD 133

  Fly   159 ELEPNEAEFAWMYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVFRQ 223
            |    |..|..:.....|..:.||....|:|..|.:.||:|::::...:|..:..||.|:::|..
Zfish   134 E----EGNFIELGGEFPLEENNHFSKLAVNTLMSDIQVPTNVYNKDPDILNGVYMSEALNDIFIN 194

  Fly   224 NYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETATCSKDIVILLDH 288
            |:|.||.|:||||.|.||..|.||..:||   |:.:...::|||.|:|||:.||..||:||::|.
Zfish   195 NFQKDPTLTWQYFCSQTGFFRLYPGIRWT---PDANGVVSFDCRNRNWYIQAATSPKDLVIVVDV 256

  Fly   289 SGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIIPCFNGALVQATPENIEVFNQQIE 353
            ||||.|.:..:||.||.:||||...|||..::.|:..|:.:.|||.|.||||..:|.|.|...::
Zfish   257 SGSMKGLKMTIAKHTINTILDTLGENDFVNVIAYTDYVSYVEPCFKGTLVQADLDNREHFKLLVD 321

  Fly   354 QLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTNSTCNQAIMLVTDGVAGNTTEVFQKYNWGNGE 418
            :| ..:|.|.:..|.:.:|::|.   |:|.....|.|||||||:|||...:...||:::||.:.:
Zfish   322 EL-HVKGEAKVKKAMKESFRILA---DARANGQGSLCNQAIMLITDGAMEDFQSVFEEFNWPDKK 382

  Fly   419 NGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVDVIATPLVLQNE 483
                   .||||||:|:::|....::|:||.|:|:|:||.||.:|.|.|::|:.|::.|:|: |.
Zfish   383 -------VRVFTYLIGRDMTFSENVKWIACNNKGFYAHVSTLADVQENVMEYLHVLSRPMVI-NH 439

  Fly   484 QHPPTWTHAFTDKTYDPKTSNEKRPR-----LMISVGVPAFDRFYRHANSTNPRARLLGVAGTDV 543
            .|...||.|:.|... |.|....:.:     .|.||.:|.|.:    ...|.....||||.|||:
Zfish   440 DHDIIWTEAYMDSVL-PNTMEVFKSKAHSLLFMTSVAMPVFSK----KKETLSHGILLGVVGTDI 499

  Fly   544 PVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKM---NPNYNSIDFTEVEHLFED 605
            |:.::.||...||||.:||:|:::||||:|.||||||:...||.   .|||||:|.:|.|  :||
Zfish   500 PLLEVMKLAPRYKLGAHGYAFLITNNGYILAHPDLRPLYYEGKKLKPKPNYNSVDLSEAE--WED 562

  Fly   606 QSPREPGESILHIRNAMVRHEANEFKSISVKFHYDKMRRVSEEKQDYFFAPLPNTPFTLGIVMPS 670
            ...        ::|.|||:.|.... ::.|:...||.:|....|.|||:..:..|||:.|:|:..
Zfish   563 TED--------NLRTAMVKGETGTL-ALDVRTAVDKGKRPLFLKNDYFYTTIDETPFSFGMVLTK 618

  Fly   671 EYGKTWIKVGEEVDKNKHMKINISDFFIGENWKVHPDWVYCK----------------YHYLEGH 719
            .:|:........|::..| .:...|..|.|      :|.||:                ..||.|
Zfish   619 GHGQYMFFGNVSVEEGLH-DLQQPDLTIAE------EWTYCETDIDPQHRKLNQLQAVVRYLTG- 675

  Fly   720 EFKTPEAELREFLAKMQNDWKWSEQYAEDESDWDDKDDLNCGRKTLGDDAYYCNKELVNLLIFDA 784
              |.||.|                                            |::.|:..::|||
Zfish   676 --KEPELE--------------------------------------------CDEILLQQVLFDA 694

  Fly   785 KVTNSSYGVWRFES------DEERQLIERFRADLRFVATMSGLTRWQFIFGEVEVDTDREFGDYH 843
            .||......|...:      ||        ..:..|:.|.||:.|.....|     .::..|...
Zfish   695 VVTAPLEAYWTRLTLTPPGVDE--------GMESAFLGTRSGVLRVIRYTG-----IEKRLGKKF 746

  Fly   844 TTAIDE----------TWYKSAILQHHEDRAESFVYSVKYYD-DPMEDSEVKVTASHAIFPRDGG 897
            .|.:|:          .||:.|.    |:....|::.|.|.| :..:::.|.||   ::...:..
Zfish   747 LTRVDKENLFTVDHFPIWYRLAA----ENTPGQFLFYVPYDDINKGKNTFVAVT---SVTVTERK 804

  Fly   898 KEAPACVVGFQFSHARMWERFFNITAVD----HCNH----CLPICTDDDVDCVVIDNNAYIVIGQ 954
            :.|.|..:|.|.| ..:.||.|...|..    .||.    |...|...|::|.::|:|.:|::.:
Zfish   805 RTAIAGAIGMQAS-LDVLERIFMSIAKQPNDTDCNDVEGICPLSCESIDLNCYLVDSNGFILMSK 868

  Fly   955 NINTTGKFFGEFHGDVMTAMVERGIFLSIEVYDYQEQCKEEPKAGSDGHGLLHPL-RLLSLGWKY 1018
            :....|:||||..|.||..:::.|::..:.:||||..||......|....||.|. .||:|
Zfish   869 DRGDVGRFFGEIDGSVMAQLLKSGLYKRVTLYDYQAMCKTGHHHSSGARPLLSPFYALLAL---- 929

  Fly  1019 LVGRLFFEYQRIQWWADGAPFMEYTDEI------EDEYVAVGDGGKSSASKPKD-------DSDD 1070
                       |:||.  :.|:.:..|.      .::||.....|..:..|.|.       :::.
Zfish   930 -----------IKWWF--SHFVMFMLEFNICGLWHNDYVVDAKAGFHTTHKQKKVELMQPCNTEY 981

  Fly  1071 ENAMFDEP--EPDPIYKA--CDKRSTLYALQPSALVGINDFVEAPSTRPFLVKKIPNSNLVLVVV 1131
            ...|:|:.  |.:.|.|.  |.|.                         |::::|||||||::||
Zfish   982 PGFMYDKSIRETNSIIKCGRCQKM-------------------------FVLQQIPNSNLVMLVV 1021

  Fly  1132 NVLMP-SRS-VRLTTEPQRMEYDKEFPCYKLNMSFYERRRIEECYTVHEDEELYTYCGNASRLVL 1194
            ..... ||. ..:|..|:.::|:....|.::. |...|||.|.|::.|..|.... ||.|..:.|
Zfish  1022 QADCDCSRQYAPITLMPKEVKYNATVKCNRMK-SQKIRRRPESCHSYHAHENAED-CGGACGITL 1084

  Fly  1195 TLQL 1198
            :|.|
Zfish  1085 SLTL 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-Ma2d	NP_001260486.1	VWA_N	124..251	CDD:285584	43/126 (34%)
		vWA_VGCC_like	267..461	CDD:238740	81/193 (42%)
		Cache_1	510..587	CDD:280839	35/76 (46%)
cacna2d4b	XP_009296274.2	VWA_N	112..222	CDD:312040	41/120 (34%)
		vWA_VGCC_like	235..418	CDD:238740	81/193 (42%)
		dCache_1	414..>533	CDD:308398	47/124 (38%)
		VGCC_alpha2	650..1028	CDD:312092	106/487 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4523
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm6553
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.770