|
Fly 714 SGAGGQKG-GAAAGAAGQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIV--EWKPFEFLIL 775
|||||:.| |:|....|....:..|.|.|.......|.||..:..|:.|:|.| .| ||.:.:
Human 26 SGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPW--FERISM 88
Fly 776 LTIFANCIALAVYTPYP--GSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNG 838
|.|..||:.|.::.|.. ..||. ..:.|:..:......|..|.|:|::|.| :.....||.:.
Human 89 LVILLNCVTLGMFRPCEDIACDSQ-RCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDT 151
Fly 839 WNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFH 903
||.|||.||:.|.:..:| .|...:| .|:|..|||||||.::.|||:::::..:|..:..|.:
Human 152 WNRLDFFIVIAGMLEYSL-DLQNVSF--SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGN 213
Fly 904 IALLVLFVIIIYAIIGLELFSGKLHKAC----------------------RDE---ITGEYEEN- 942
:.||..||..|:.|:|::|::|.|...| .|| |..:..||
Human 214 VLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENG 278
Fly 943 ---------IR-------PCGVGYQCPPGY----------------KCYGGWDGPNDGITNFDNF 975
:| |||:.|: .| .|..|...|..|..||||.
Human 279 MRSCRSVPTLRGDGGGGPPCGLDYE---AYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNI 340
Fly 976 GLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNK 1040
|.|.:.:||.:|||||.|::|.:.|| .|.:.::|||.::|:|:||::||.|.|::.:||:.:.:
Human 341 GYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR 404
Fly 1041 AKNRGDFQKLR------------EKQQIEEDLRGYLDWI-------------------------- 1067
.......|::| |.....|:|..||.:|
Human 405 ESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPA 469
Fly 1068 ------TQ--------------------------------------------------------- 1069
||
Human 470 PLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLML 534
Fly 1070 ---------------AEDI----------EP------------DAVGGLISDGK----------- 1086
||.: || :|.|..:..||
Human 535 PPPSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPP 599
Fly 1087 -------------GKQPNEMDS----------------TENLG---------------------- 1100
...|..:.| |::.|
Human 600 ETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGP 664
Fly 1101 ------------------EEMPE------VQMTES------------RWRKMKKDFD--RVNRRM 1127
.|||: .:.|:. |.|.:..|.: .|....
Human 665 DSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFW 729
Fly 1128 RRAC---RKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKM 1189
|..| ||.|.|:.|...|::.:.:||..:..|::.|.:.|.|..|.:|:.|..||..|||||:
Human 730 RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKL 794
Fly 1190 YSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNL 1254
...|..||..:.:|.||..:|:.|:.|.:....| |:||||..||:||.|:.::..:|...
Human 795 LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKLVRFLPALQRQ 854
Fly 1255 VASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKF--NFDGKEEKYRMNFDCFWQALLTVFQI 1317
:..|:.::.::|:..:||.|||.||::|||.:||.|| ..||.....|.|||....|::|||||
Human 855 LVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQI 919
Fly 1318 MTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEK 1382
:|.||||.|: |.|::|..:.|.:|||.|...|||:|.|:.:||.|:.. ...|:.|
Human 920 LTQEDWNKVL------YNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGF----QAEEISK 974
Fly 1383 EEE----------PHDE---SAQKKSHSP---TPTIDGMDDH----------------------- 1408
.|: |.|. .|.|....| :|::||..|.
Human 975 REDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPL 1039
Fly 1409 --------LSID----------------------------------------------------- 1412
:|:.
Human 1040 IIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWT 1104
Fly 1413 ---------------------------IDMEQQELDDEDKMDHETL-----SDEEVREMCEEE-- 1443
:..|.||..||::...|.. ||...|...|.|
Human 1105 SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAK 1169
Fly 1444 ----------------------------------------------------EEVDEEGMITARP 1456
::.|:||.::...
Human 1170 SSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGE 1234
Fly 1457 RRMSEVNTATKILPI----PPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAE 1517
|..:.:... ||. ....|.::|...:|||:.||.:..|..|.:::|..|..:...:|.|
Human 1235 RVRAWIRAR---LPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAME 1296
Fly 1518 NPLRANDDLNKV-LNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVS---- 1577
.|........:: |...:|.|||||..|:.:|:::.|:...:.|:.||::|:||.|:|.:|
Human 1297 RPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI 1361
Fly 1578 LISLVSSSNA--ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMF 1640
|:|:||.|.. :.::::||:||.|||||.|:||:|||.||:.::.::|.|||||::.| .|
Human 1362 LVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC----AF 1422
Fly 1641 AVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGT 1705
.:| |.::||||||||||.| |.| .|
Human 1423 FII--------------------------------FGILGVQLFKGKFFVC-------QGE--DT 1446
Fly 1706 YLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHN 1770
..:.:..|..:...| |..::::||::.:.:::||.:::.:||..::|..:|:...:..||.|
Human 1447 RNITNKSDCAEASYR---WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMN 1508
Fly 1771 FRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF----QNEGEQEYKNCD------LDKNQRNCI-- 1823
..|.:..|:|.:::|:|||::|:|||.|:..| |::.|:|.:..: |:|.:||.:
Human 1509 HNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLD 1573
Fly 1824 ---------EFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLW 1879
..|.:|:....|......:..|....||...:..|..:|.:|.||:||:.|.||..
Human 1574 DVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQI 1638
Fly 1880 YTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQI 1944
..|.|...|.|||.:|.||.||||.||.|:.:|.|.||..|..|||.|.:.|...||:
Human 1639 LDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIE------- 1696
Fly 1945 AECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV---A 2006
...|...|...|...|:.|:.|::|||....|:|.||.|.: ||||.| .
Human 1697 -----------VNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVM---QALPQVGNLG 1747
Fly 2007 LLIVLLFFIYAVVGMQVFGKIALDGGN---AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCS 2068
||.:|||||:|.:|:::||.:..|..: .:..:..|:.|..|.|.|||.:||:.|..||....
Human 1748 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTL 1812
Fly 2069 AQPDVKCDMNSDTPGEPCGSSIAYP-YFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHH 2132
.. ||..| .|.:::..| ||:||.:...|:::|:.:||:| .|
Human 1813 RD----CDQES-----TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM---------------KH 1853
Fly 2133 LDEFIRLWSEYDPDAKGRIK---HLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSD-- 2192
|:| |..:...:..:: .|::.||..:...|||...|.| .:..|.:.|
Human 1854 LEE-----SNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWP---------GVEGPDSPDSP 1904
Fly 2193 --GTVLFNATLFAVVRTSLSIKTDGNIDDANSEL-RATIKQIWKRTNPKLLDQVVPPPGNDDEVT 2254
|.:...|...:....||...||..:.|..|.| :.::: |:. ||:|::..|.|...
Human 1905 KPGALHPAAHARSASHFSLEHPTDRQLFDTISLLIQGSLE--WEL---KLMDELAGPGGQPS--- 1961
Fly 2255 VGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVS-PALKRAISGNLDELDQ 2318
.|.......|.: |......::|...|...|| |:...|::. |.
Human 1962 ---------------AFPSAPSLGGSD--PQIPLAEMEALSLTSEIVSEPSCSLALTD-----DS 2004
Fly 2319 EPEPMHRRHHTLFGSVWSSIRRHGNG-------TFRRS-AKATASQSNGALAI--GGSASAALGV 2373
.|:.||. .|..::.|:::.|... |.|:| ...|.|..|.:... |.:|...||.
Human 2005 LPDDMHT---LLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGH 2066
Fly 2374 GG--------SSLVLGSSDPAGGDYL------------------YDTLNRSVADGVNNITRNIMQ 2412
.| .|::...|.||...|: :.|:.:....|.:.:.:..::
Human 2067 RGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLR 2131
Fly 2413 ARLAAAGKLQDELQGAGSGGELRTFGESISMRPLAKNGGGAATVAGTLPPEANAINY-------- 2469
|.||......::||.||..:| .|.|:|..||.|.|.::
Human 2132 -RQAAIRTDSLDVQGLGSREDL------------------LAEVSGPSPPLARAYSFWGQSSTQA 2177
Fly 2470 ---DNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAA 2531
...:..|..| ..|....||.|......| |..:..|...::: |.|.|.|..
Human 2178 QQHSRSHSKISKH-----MTPPAPCPGPEPNWGKGP--PETRSSLELDTEL-----SWISGDLLP 2230
Fly 2532 EGLG----------KYCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSLSLIGSSNGSIF 2586
.| | |.|.|....:..|.....|| |:.. |.| ::|.:.|.:....
Human 2231 PG-GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLD---EQRR---HSI-----AVSCLDSGSQPHL 2283
Fly 2587 GGSAGGLGGAGSGGVGGLGGSSSIRNAFGGSGSGP-SSLSPQ----HQPYSGTLNSPPIPDNRLR 2646
|.....||| ...||.||.| ..|||. ..|.|....:||.|...||
Human 2284 GTDPSNLGG----------------QPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLR 2332
Fly 2647 RVATVTTTNNNNKSQVSQNNSNSL 2670
|.| .::::|..::....:|:
Human 2333 RRA----PSSDSKDPLASGPPDSM 2352
| 
