DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and CACNA1H

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_006721026.1 Gene:CACNA1H / 8912 HGNCID:1395 Length:2358 Species:Homo sapiens


Alignment Length:2603 Identity:609/2603 - (23%)
Similarity:965/2603 - (37%) Gaps:930/2603 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   658 GFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGG 722
            |.||...|.||     |.|...|   :||                        :.||.:...:.|
Human    27 GASPESPGAPG-----REAERGS---ELG------------------------VSPSESPAAERG 59

  Fly   723 AAAGAAGQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIV--EWKPFEFLILLTIFANCIAL 785
            |..||..::|     .|.|.......|||......|:.|:|:|  .|  ||.:.:|.|..||:.|
Human    60 AELGADEEQR-----VPYPALAATVFFCLGQTTRPRSWCLRLVCNPW--FEHVSMLVIMLNCVTL 117

  Fly   786 AVYTPYP----GSD-SNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFT 845
            .::.|..    ||: .|:    ||..:......|..|.|:|::|.| :.....||.:.||.|||.
Human   118 GMFRPCEDVECGSERCNI----LEAFDAFIFAFFAVEMVIKMVALG-LFGQKCYLGDTWNRLDFF 177

  Fly   846 IVVIGAISTALSQLMKDAFDV--KALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLV 908
            |||.|.:..:|     |..:|  .|:|..|||||||.::.|||:::::..:|..:..|.::.||.
Human   178 IVVAGMMEYSL-----DGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLC 237

  Fly   909 LFVIIIYAIIGLELFSGKLHKAC-------RDE---------ITGEYEEN--------------- 942
            .||..|:.|:|::|::|.|...|       |:.         .|.|.|||               
Human   238 FFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKC 302

  Fly   943 --------IR-PCGVGYQC---PPG----------------YK-CYGGWDGPNDGITNFDNFGLA 978
                    :| ||.:|::.   |..                |. |..|...|::|..||||.|.|
Human   303 SHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYA 367

  Fly   979 MLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKN 1043
            .:.:||.:|||||.|::|.:.|| .|.:.::|||.::|:|:||::||.|.|::.:||:.:.:   
Human   368 WIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR--- 428

  Fly  1044 RGDFQKLREKQQ------------------IEE---------------DLRGYLDWITQ-AEDIE 1074
              :.|.:||::.                  .||               .||.|..|.:: .:.::
Human   429 --ESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVD 491

  Fly  1075 PDAVGGL---------------------------------------------------------- 1081
            |.||.|.                                                          
Human   492 PSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAP 556

  Fly  1082 ----------------------------------------------------------------I 1082
                                                                            :
Human   557 PSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPTILPSGV 621

  Fly  1083 SDGKGKQ-------------------PNEMDSTE------------NLGE--------------- 1101
            ..|||..                   |..::|.:            .||:               
Human   622 GSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLP 686

  Fly  1102 ---------------------EMPEVQMTES---------------------RWRKMKKDFDRVN 1124
                                 |.||.:::.|                     ||     |..|..
Human   687 SPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRW-----DPTRPP 746

  Fly  1125 RR-----------MRRA----------------------CRKAVKSQAFYWLIIVLVFLNTGVLA 1156
            |.           .|||                      .|:.|.|:.|...|::.:.:||..:.
Human   747 RATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMG 811

  Fly  1157 TEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTN 1221
            .|::.|.:.|.|..|.:|:.|..:|..|||||:.:.|..||..:.:|.||..:|:.|:.|.:...
Human   812 VEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA 876

  Fly  1222 TGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQV 1286
            .|     |:||||..|||||.|:.::..:|...:..|:.::.::|:...||.|||.||::|||.:
Human   877 DG-----GLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHL 936

  Fly  1287 FGGKFNF---DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYF 1348
            ||.||:.   .|.....|.|||....|::|||||:|.||||.|:      |.|::|..:.|.:||
Human   937 FGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL------YNGMASTSSWAALYF 995

  Fly  1349 IILFICGNYILLNVFLAIAVD--------NLADAD-------------SLSEVEKEE-------- 1384
            :.|...|||:|.|:.:||.|:        |.:|.|             .|.|::..|        
Human   996 VALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV 1060

  Fly  1385 EPHDESAQKKSHSP----------------TPTID---GMDDHLSIDIDMEQQELDDEDKM---- 1426
            .|:.....:.|.||                :|.:|   .:.|............|.|:...    
Human  1061 TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLR 1125

  Fly  1427 ------------------------------------DHETLSDEEVREMCEEEEE---------- 1445
                                                :.|:|...|.:...::|.|          
Human  1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRA 1190

  Fly  1446 ------------------------VDEEGMITARP-----------RRMSEVNTAT--------- 1466
                                    .|.:|.:.|.|           ...:|::..:         
Human  1191 TPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLH 1255

  Fly  1467 KIL-PIPP-------GTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRAN 1523
            |:| |..|       ..:.:|||..|||||.|..:..|..|.:::|..|..:...:|.|.|....
Human  1256 KVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDP 1320

  Fly  1524 DDLNKV-LNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLV----- 1582
            ....:| |:..:|.|||:|..|:::|:::.|.:..:.|:.:|::||||.|:|.|||:.:|     
Human  1321 GSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMAS 1385

  Fly  1583 -SSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQ 1646
             ..:..:.|:::||:||.|||||.|:||.|||.||:.:|.:::.||||||:.|    .|.:|   
Human  1386 AGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICC----AFFII--- 1443

  Fly  1647 LFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDG----SKMTQDECYGTYL 1707
                                         |.::|||||||||:.| :|    :..|:.:|     
Human  1444 -----------------------------FGILGVQLFKGKFYYC-EGPDTRNISTKAQC----- 1473

  Fly  1708 VYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFR 1772
                      |.....|...:::||::.:.:::||.:|:.:||..::|..:|:...:..|:.|..
Human  1474 ----------RAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528

  Fly  1773 PIVAAYYIIYIIIIAFFMVNIFVGFVIVTF----QNEGEQEYKNCD------LDKNQRNCIEFAL 1827
            |.:..|:|.:::|::||::|:|||.|:..|    |::..:|.:..:      |::.:|:      
Human  1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRS------ 1587

  Fly  1828 KAKPV--------RR--YIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTE 1882
            ||.||        ||  |......:..:....||...:..|..:|.:|.:|::|:.||||....|
Human  1588 KALPVAVAVAEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDE 1652

  Fly  1883 LLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAEC 1947
            .|...|.:||.||..|...||.||.|:.:|.|.||..|..|||.|.:.|...||:......|   
Human  1653 ALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPI--- 1714

  Fly  1948 DIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV---ALLI 2009
                           |...|...|:.|:.|::|||....|:|.||.|.:   ||||.|   .||.
Human  1715 ---------------NPTIIRIMRVLRIARVLKLLKMATGMRALLDTVV---QALPQVGNLGLLF 1761

  Fly  2010 VLLFFIYAVVGMQVFGKIALDGGN---AITANNNFQTFQQAVLVLFRSATGEAWQEIM----MSC 2067
            :|||||||.:|:::||::.....|   .::.:..|..|..|.|.|||.:||:.|..||    ..|
Human  1762 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLREC 1826

  Fly  2068 SAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHH 2132
            |.: |..|  .|..|      :::..||::|.::..|:::|:.|||:|.:.:...::  ......
Human  1827 SRE-DKHC--LSYLP------ALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKE--AREDAE 1880

  Fly  2133 LDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPL-----GFGKLCPHRMACKRLVSMNMPLNSD 2192
            ||..|.|.....|   |..:.:|.      ..|||     | .:..|:.:|.|..||..:.|.:|
Human  1881 LDAEIELEMAQGP---GSARRVDA------DRPPLPQESPG-ARDAPNLVARKVSVSRMLSLPND 1935

  Fly  2193 GTVLFNATLFAVVRTS---------LSIKTDG---------NIDDANSELRATIKQIWKRTNPKL 2239
             :.:|.    .||..|         :.::|.|         ::....:|..|:::.....::|..
Human  1936 -SYMFR----PVVPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQIPLAVSSPAR 1995

  Fly  2240 LDQ---VVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEV 2301
            ..:   .:.|.|.....::.:...               .||..  |.||....:.:...||...
Human  1996 SGEPLHALSPRGTARSPSLSRLLC---------------RQEAV--HTDSLEGKIDSPRDTLDPA 2043

  Fly  2302 SPALKRAI-----SGNLDELDQEPEP--MHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNG 2359
            .|..|..:     .|:|....:.|.|  :..|.|| ||....|.|                    
Human  2044 EPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHT-FGQRCVSSR-------------------- 2087

  Fly  2360 ALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLN---------------RSVADGVNNITRN 2409
            ..|.||..:.|            ||||..:..:.|.:               ..||.|..::.|.
Human  2088 PAAPGGEEAEA------------SDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRL 2140

  Fly  2410 I---MQARLAAAGKLQDELQ-----GAGSGGELRTFGES-----------------ISMRPLAKN 2449
            .   .|..|...|:..::.:     |:|..||.:.:|..                 ||:.|.|::
Human  2141 YSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAED 2205

  Fly  2450 GGGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTP---ASPYDQRRL 2511
            .|.|                                .|:.|..|...:.:.||   |:|:.....
Human  2206 EGSA--------------------------------RPSAAEGGSTTLRRRTPSCEATPHRDSLE 2238

  Fly  2512 PTSSDMNGLAESLIGGVLAAEG--LGK-YCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEH 2573
            ||..       |..||..||:|  .|: .|.:|.: |......|.||                  
Human  2239 PTEG-------SGAGGDPAAKGERWGQASCRAEHL-TVPSFAFEPLD------------------ 2277

  Fly  2574 SLSLIGSSNGSIFGGSAGGLGGAGSGGVGGLGGSSSIRNAFGGSGSGPSSLSPQHQPYSGTLNSP 2638
                :|..:|..|                 |.||.|:......|.||  ::.|...|.|    .|
Human  2278 ----LGVPSGDPF-----------------LDGSHSVTPESRASSSG--AIVPLEPPES----EP 2315

  Fly  2639 PIP 2641
            |:|
Human  2316 PMP 2318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 106/341 (31%)
Ion_trans 1137..1379 CDD:395416 92/265 (35%)
Ion_trans 1496..1809 CDD:395416 97/327 (30%)
Ion_trans 1851..2126 CDD:395416 94/284 (33%)
GPHH 2135..2188 CDD:407139 14/57 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 10/92 (11%)
CACNA1HXP_006721026.1 Ion_trans 149..430 CDD:278921 91/292 (31%)
Ion_trans 810..1019 CDD:278921 83/219 (38%)
Ion_trans 1317..1565 CDD:278921 90/299 (30%)
Ion_trans 1639..1852 CDD:278921 83/242 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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