DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and CACNA1I

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_066919.2 Gene:CACNA1I / 8911 HGNCID:1396 Length:2223 Species:Homo sapiens


Alignment Length:2485 Identity:593/2485 - (23%)
Similarity:937/2485 - (37%) Gaps:848/2485 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   739 PQPDRPQRALFCLSVKNPLRALCIRIV--EWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQ 801
            |.||....|.|||......|..||::|  .|  ||.:.:|.|..||:.|.:|.|....|......
Human    50 PHPDLAPIAFFCLRQTTSPRNWCIKMVCNPW--FECVSMLVILLNCVTLGMYQPCDDMDCLSDRC 112

  Fly   802 TLEKV--EYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAF 864
            .:.:|  :::| :.|..|.|:|::|.| :.....||.:.||.|||.||:.|.:..:|.   ....
Human   113 KILQVFDDFIF-IFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLD---LQNI 172

  Fly   865 DVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHK 929
            ::.|:|..||||||:.::.|||:::::|.:|..:..|.::.||..||..|:.|||::|::|.|..
Human   173 NLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRN 237

  Fly   930 ACRDE----ITGEY---------EENIRP--CGVG--------YQCPP----GYKC--------- 958
            .|..|    |.|:.         |::..|  |.:.        ::.||    |.:|         
Human   238 RCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYD 302

  Fly   959 YG-------------GWD-----------GPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQ 999
            :|             .|:           .|:.|..||||.|.|.:.:||.:|||||.:::|.:.
Human   303 FGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM 367

  Fly  1000 DAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFS--KER------------------------ 1038
            || .|.:.::|||.::|:|:||::||.|.|::.:||  |:|                        
Human   368 DA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEP 431

  Fly  1039 ---------------NKAKNR--GDFQKLREKQQI--------------EEDLRGY--------- 1063
                           .|||.|  |.:|.|:.::|.              .::.|.|         
Human   432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGD 496

  Fly  1064 ----------------------------------LDW---------------------ITQAED- 1072
                                              ||.                     ..|.|| 
Human   497 EGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDG 561

  Fly  1073 IEPDAVGGLIS-----------------DGKGKQPNEMDSTENLGEEMPEVQMTESR-------W 1113
            ..|..:|...|                 ||.|.:.:|..::..||:|..|.:..:..       |
Human   562 RRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVW 626

  Fly  1114 RKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFI 1178
            |:           .|...|..|.|:.|...|::.:.:||..:..||:.|.:.|.|..|..||.|.
Human   627 RE-----------TRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFT 680

  Fly  1179 GLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFK 1243
            .:|..||:||:.:.|...|..:.:|.||..:||.||.|.:....|     |:||||..|||||.|
Human   681 SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADG-----GLSVLRTFRLLRVLK 740

  Fly  1244 VTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF---DGKEEKYRMNFD 1305
            :.::..:|...:..|:.::.::|:..:||.|||.||::|||.:||.||:.   .|.....|.|||
Human   741 LVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805

  Fly  1306 CFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVD- 1369
            ....|::|||||:|.||||.|:      |.|::|....|.:||:.|...|||:|.|:.:||.|: 
Human   806 SLLWAIVTVFQILTQEDWNVVL------YNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEG 864

  Fly  1370 ---------NLADAD----SLSEVEKEEEPHDESAQKK--------------------------- 1394
                     :.:|.|    ::.|.:|.:|..|.|...|                           
Human   865 FQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGA 929

  Fly  1395 -------SHSPTPTIDGMDDHLSIDIDMEQQELDDED---------------------------- 1424
                   |..|.|.:..:....|..:.:.:...|...                            
Human   930 AGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL 994

  Fly  1425 -----KMDHETL---------------SDE----------------------------------- 1434
                 ..:||:|               :||                                   
Human   995 KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSL 1059

  Fly  1435 ------EVREM-----------------------C----------------------EEEEEVDE 1448
                  ::.|:                       |                      |:|||:|.
Human  1060 DNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDY 1124

  Fly  1449 EGMITARPRRMSEVNTATKILP----IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMF 1509
              .:..|.|:|.:|     ..|    :....|.:|||..|||||.|..:..|..|..::|..|..
Human  1125 --TLCFRVRKMIDV-----YKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFL 1182

  Fly  1510 SSAMLAAENP-LRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLV 1573
            :...:|.|.| :.|.......|...:|.|||:|..|:.||::|.|....:.|:.||::|:||..:
Human  1183 NCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFL 1247

  Fly  1574 VCVSLISLVSS------SNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLV 1632
            |.||:|.:|.|      :..:.|:::||:||.|||||.|:||.|||.||:.:|.::|.||||||:
Human  1248 VFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLI 1312

  Fly  1633 TCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKC--TDGS 1695
            .|    .|.:|                                |.::|||||||||:.|  .|..
Human  1313 CC----AFFII--------------------------------FGILGVQLFKGKFYHCLGVDTR 1341

  Fly  1696 KMT-QDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSID 1759
            .:| :.:|...               ...|.:::::||::.:.:::||.:::.:||..::|..:|
Human  1342 NITNRSDCMAA---------------NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1391

  Fly  1760 SNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF----QNEGEQEYKNCD------ 1814
            :...:..|:.|..|.:..|:|.:::|::||::|:|||.|:..|    |::..:|.:..:      
Human  1392 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1456

  Fly  1815 LDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLW 1879
            |:|.:|       ||:.:..|......:..:....||...:..|..:|.:|.||::::.||||..
Human  1457 LEKKRR-------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTS 1514

  Fly  1880 YTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQI 1944
            ....|...|.:||.||.||.|.||.||..:.:|.|.||..|..|||.|.:.|...||:......|
Human  1515 LETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPI 1579

  Fly  1945 AECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV---A 2006
                              |...|...|:.|:.|::|||....|:|.||.|.:   ||||.|   .
Human  1580 ------------------NPTIIRIMRVLRIARVLKLLKMATGMRALLDTVV---QALPQVGNLG 1623

  Fly  2007 LLIVLLFFIYAVVGMQVFGKIALDGGN---AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCS 2068
            ||.:|||||||.:|:::|||:..:..|   .::.:..|:.|..|.|.||:.:||:.|..||    
Human  1624 LLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIM---- 1684

  Fly  2069 AQPDVKCDMNSDTPGEPCGSSIAYP---YFISFYVLCSFLIINLFVAVIMDNFD----------Y 2120
              .|...|...|.  ..|.||:.:.   ||:||.:...|::||:.|||:|.:.|          .
Human  1685 --KDTLRDCTHDE--RSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAE 1745

  Fly  2121 LTRDWSILGPHHLDEFIRLWSEYDPDAKGR-------------------------IKHLDVVTLL 2160
            :..:..:...|.|....|| ....|.|.||                         ...||.|:|:
Human  1746 MDAELELEMAHGLGPGPRL-PTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLI 1809

  Fly  2161 RK--------------------ISPPLGFGKLCPHRMACKRLVSMN-MPLNSD--GTVLFNATLF 2202
            .|                    .|.|.|. |.|.|.....:|.... ..||||  .::|..    
Human  1810 IKDSLEGELTIIDNLSGSIFHHYSSPAGC-KKCHHDKQEVQLAETEAFSLNSDRSSSILLG---- 1869

  Fly  2203 AVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDY 2267
                           ||.:.|                 |....|||                   
Human  1870 ---------------DDLSLE-----------------DPTACPPG------------------- 1883

  Fly  2268 FRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHE-VSPALKRAISGN----LDELDQEPEPMHRRH 2327
                  ||:.:|:...|:    .::.|  .|.| ..|....|:|.:    |.|:::.|       
Human  1884 ------RKDSKGELDPPE----PMRVG--DLGECFFPLSSTAVSPDPENFLCEMEEIP------- 1929

  Fly  2328 HTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLY 2392
               |..|.|.::..       |::|..|              ......||.:|    |...::.:
Human  1930 ---FNPVRSWLKHD-------SSQAPPS--------------PFSPDASSPLL----PMPAEFFH 1966

  Fly  2393 DTLNRS-----VADGVNNITRNIMQARLAA--AGKLQDELQGAGSGGELRTFGESISMRPLAKNG 2450
            ..::.|     ...|...:.:..:|...|:  :.::...|....:|.:     .|:...|.:..|
Human  1967 PAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSD-----TSLDASPSSSAG 2026

  Fly  2451 GGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSS 2515
            ....|:..:|...      |:..|.:         .|....||....:     ||..:|||    
Human  2027 SLQTTLEDSLTLS------DSPRRAL---------GPPAPAPGPRAGL-----SPAARRRL---- 2067

  Fly  2516 DMNGLAESLIG-GVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSLSLIG 2579
                   ||.| |:.:..|                             |.|||   ..|      
Human  2068 -------SLRGRGLFSLRG-----------------------------LRAHQ---RSH------ 2087

  Fly  2580 SSNGSIFGGSA--GGLGGAGSGGVGGLGGSSSIRNAFGGSGSGPSSLSPQHQPYSGTLNS----- 2637
            ||.||...|..  ..:..:...|.||.||        ||:||          .:|.||:|     
Human  2088 SSGGSTSPGCTHHDSMDPSDEEGRGGAGG--------GGAGS----------EHSETLSSLSLTS 2134

  Fly  2638 -------PPIPD----NRLRRVATVTTTNNNNKSQVSQNNSNSLNVRANANSQ--------MNMS 2683
                   ||.|.    .:....:::......:.:.::...:.|.:..|:.:..        |.:.
Human  2135 LFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLG 2199

  Fly  2684 PTGQPVQQQSPLRGQ 2698
            |...|.|   ||.|:
Human  2200 PLAPPPQ---PLPGE 2211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 103/377 (27%)
Ion_trans 1137..1379 CDD:395416 92/258 (36%)
Ion_trans 1496..1809 CDD:395416 98/326 (30%)
Ion_trans 1851..2126 CDD:395416 97/293 (33%)
GPHH 2135..2188 CDD:407139 18/98 (18%)
Ca_chan_IQ 2199..2271 CDD:400901 7/71 (10%)
CACNA1INP_066919.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
I 66..401 102/342 (30%)
Ion_trans 127..409 CDD:278921 88/286 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..536 4/68 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..616 14/60 (23%)
II 626..865 95/260 (37%)
Ion_trans 657..866 CDD:278921 85/219 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..936 1/36 (3%)
III 1157..1434 102/327 (31%)
Ion_trans 1202..1441 CDD:278921 90/289 (31%)
IV 1472..1733 97/289 (34%)
Ion_trans 1504..1741 CDD:278921 91/265 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1758..1784 7/26 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1868..1897 11/93 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1937..1960 6/47 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2013..2062 11/73 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2076..2223 36/195 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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