Protein Alignment Ca-alpha1D and CCH1

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: NP_011733.3
• Gene: CCH1 / 853131
• SGDID: S000003449
• Length: 2039
• Species: Saccharomyces cerevisiae
• Alignment Length: 2130
• Identity: 413/2130 - (19%)
• Similarity: 764/2130 - (35%)
• Gaps: 656/2130 - (30%)

  Fly   422 NCDITGDNSTLHGFGVGDVCSFIADCDDNSEDDDGDPNNQDLSSQTLRTAAIVAAVAAAAKEQAQ 486
            |.:..|||:.:          ...:.:||||.|.   |..:...|.|...|:......::....:
Yeast    15 NTNPFGDNAAV----------MTENVEDNSETDG---NRLESKPQALVPPALNIVPPESSIHSTE 66

  Fly   487 EQSLADCESFSDRRQDADEDVRIIQDCC-----GGNNDSLE---------DVGEVDDNADVVVRK 537
            |:.       .|.....|:|..:|.:..     ..::::|.         ..|..:.:     |:
Yeast    67 EKK-------GDEYNGNDKDSSLISNIFRTRVGRSSHENLSRPKLSLKTASFGAAESS-----RR 119

  Fly   538 N-SRNRPSIRRTCRITEEDDDEDENADYGDFDREDQELDDEEPEGTTIDIDEQEQQHDQGDSAEE 601
            | |.:..|.:.:.:..:.:|:......:..:.|.........|..|  |...:..:.....:|::
Yeast   120 NVSPSTKSAKSSSQYIDLNDERLRRRSFSSYSRSSSRRVSNSPSST--DRPPRSAKVLSLIAADD 182

  Fly   602 EDDDEDVDEYFEE--EEDDTQAFSPFYSSSAELIDNFG--GGAGKFFNIMDFERGASGEGGFSPN 662
            .||.||:.:.|:.  :|:.........|..:..:.:.|  .|.|:..:|.|..         :||
Yeast   183 MDDFEDLQKGFKSAIDEEGLTWLPQLKSEKSRPVSDVGEDRGEGEQESIPDVH---------TPN 238

  Fly   663 GNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGA 727
            .......|.:..|                           ||.            .|.|..:.|.
Yeast   239 VGASATPGSIHLT---------------------------PEP------------AQNGSVSEGL 264

  Fly   728 AGQKRQQRRGKPQP-----------DRPQ-----------------------------RALFCLS 752
            .|.....|: ||.|           |:.|                             .:|...|
Yeast   265 EGSINNSRK-KPSPKFFHHLSPQKEDKDQTEVIEYAEDILDFETLQRKLESRPFVLYGHSLGVFS 328

  Fly   753 VKNPLRALCIRIVEWKPFEFL--ILLTIFANCIALAVYTPYPGSDSNV------TNQTLEKVEYV 809
            ..||||....|.:..:.:..|  .|||.:|..:|:..|.|:     ||      :|.|    :|.
Yeast   329 PTNPLRIKIARFLLHRRYSLLYNTLLTFYAILLAIRTYNPH-----NVVFLYRFSNWT----DYF 384

  Fly   810 FLVI---FTAECVMKILAYGF----------------VLHNGA------YLRN--GWNLLDFTIV 847
            ..::   ||...:.||:|:||                :|....      |||.  |..|:||.|.
Yeast   385 IFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRSGIMKLYIYLREKYGRKLIDFIIP 449

  Fly   848 --VI----------GAISTALSQ--------------------------------------LMKD 862
              :|          .::||:|::                                      |...
Yeast   450 FRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSIK 514

  Fly   863 AFDVK-ALRAFR---VLRPLRLV---SGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGL 920
            ::|.| .:|.|:   :||.||||   :|:||   :|..:...:..|.:::.::::..|.:.|:|:
Yeast   515 SYDTKTGIRIFKPLAILRILRLVNVDTGMPS---ILRGLKYGIPQLVNVSSMLVYFWIFFGILGV 576

  Fly   921 ELFSGKLHKAC----RDEITGEYEENIRPCG------------------------VGYQCPPGYK 957
            ::|.|...:.|    .::.|..|:.:::.||                        .|:.||...|
Yeast   577 QIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVTKRKQNYIYEDGSEGSVSKGFLCPQYSK 641

  Fly   958 CYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQ--WMYFISMVILGAF 1020
            |... ..|.:|..:|||...:|..||..::...:||::|...|   ||..  .::||..:.:...
Yeast   642 CVSN-ANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMD---SDEMAACLFFIVCIFVLTI 702

  Fly  1021 FVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDG 1085
            :::||::.||...|.....:.|.:......|:...:...:.||..:..             :...
Yeast   703 WLLNLLIAVLVSSFEIANEEYKKKKFIYGSRKTGYVARIVTGYWKYFK-------------LKAN 754

  Fly  1086 KGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFY----WLIIV 1146
            :.|.||                     |.:                    |..|.|    ::.::
Yeast   755 QTKFPN---------------------WSQ--------------------KGLAIYSHVEFIFVI 778

  Fly  1147 LVFLNTGVLATEHYGQLDWLDNFQEYTN-----VFFIGLFTCEML--LKMYSLGFQGYFVSLFNR 1204
            |:..:.|:.|:.........:|....|:     |.||     |.|  |.:|......:.......
Yeast   779 LIICDIGMRASVKVSTSANCNNILLKTDRGISIVLFI-----ESLARLVLYLPNMWKFLTKPSYV 838

  Fly  1205 FDCFVVIGSITETLLTNTGMMPPL--GVSVLRCVRLLRV---FKVT-KYWRSLSNLVASLLNSIQ 1263
            :|..:.|.::..:.|...|::..:  .:|:....|..||   |.:| |.|:.:      |.|.:.
Yeast   839 YDFIISIITLVISCLAVEGVLGHMYAWLSIFHISRFYRVIISFNLTKKLWKQI------LSNGVM 897

  Fly  1264 SIASLLLLLFLFIVIFALLGMQVFGGKFNFDG---KEEKYRMNFDCFW--QALLTVFQIMTGEDW 1323
             |.:|....|.|..:.|:: |.|:     |:|   .||.....|..:.  .:.|::|.|.:.|:|
Yeast   898 -IWNLSSFYFFFTFLVAII-MAVY-----FEGVIPPEEMADQPFGMYSLPNSFLSLFIIGSTENW 955

  Fly  1324 NAVMYVGINAYGGVSSYGALAC-IYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEP- 1386
            ..::|........:||  ...| ::|||.|:..|.::||:|:|:.      ::|:...|:|:.|
Yeast   956 TDILYALQKHSPNISS--TFFCSVFFIIWFLLSNSVILNIFIALI------SESMEVKEEEKRPQ 1012

  Fly  1387 ---------HDESAQKKSHSPTPTIDGMDDHLSIDIDMEQQELD---DEDKMDHETL-------- 1431
                     :.:..|:.:|:            |:...:.::...   :||..|.:..
Yeast  1013 QIKHYLKFVYPQKIQEYTHA------------SLVARIRKKFFGGHRNEDTRDFKQFLMRGTAIM 1065

  Fly  1432 -SDEEVREMCEEEEEVDEE------------GMITARPRRM-----------------SEVNTAT 1466
             ..:.:.|:.:|.:|...|            |:.:.:..||                 :::|..|
Yeast  1066 NIAQNMGELADEFKEPPSENLFKKGLSKLTIGVPSLKRLRMFANNPFYKNSDVVFTETNDINGRT 1130

  Fly  1467 KILPIPP---------------GTSFFLFSQTNRFRVFCHWLC---------------------- 1494
            .||.:..               ..|::.||..:|||.||..|.
Yeast  1131 YILELNEYEDEKLDYLKKYPLFNYSYYFFSPQHRFRRFCQRLVPPSTGKRTDGSRFFEDSTDLYN 1195

  Fly  1495 NHSNFGNI----------------ILC-CIM--------------FSSAMLAAENPLRANDDLNK 1528
            ..|.|.:|                |:| |.:              :|||:
Yeast  1196 KRSYFHHIERDVFVFIFALATILLIVCSCYVTPLYRMHHKMGTWNWSSAL--------------- 1245

  Fly  1529 VLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLV----SSSNAIS 1589
                 |..|...|:||.|:|.::.||:....|:.|:.:|.:|..|:....|:|:    ::.|...
Yeast  1246 -----DCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCVLISMWINLIAYLKNNGNLSR 1305

  Fly  1590 VVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKC 1654
            :.|.|..||.||.|...|.|:                                   |.|..|
Yeast  1306 IFKGLTALRALRCLTISNTAR-----------------------------------QTFNLV--- 1332

  Fly  1655 VVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTY--LVYDDGDVHKP 1717
            :...:..|....|::..|.|.|.|.|:.:|||:...|.||| :.:.:||..|  .|: ..|:..|
Yeast  1333 MFDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCNDGS-LGRADCYNEYSNSVF-QWDIMSP 1395

  Fly  1718 RLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIV-----AA 1777
            |:.::.:    .|.|..|....:|:.:.:.|||..||     .|..|...|.....::     |.
Yeast  1396 RVYQQPY----LHLDSFASAFSSLYQIISLEGWVDLL-----ENMMNSSGIGTPATVMGSAGNAL 1451

  Fly  1778 YYIIYIIIIAFFMVNIFVGFVI-----------VTFQNEGEQEYKNCDLDKNQRNCIEFALKAKP 1831
            :.:::..:...|::|:||.|::           .|.:.:...|.:.. |.:.:...|...::...
Yeast  1452 FLVLFNFLSMVFILNLFVSFIVNNQARTTGSAYFTIEEKAWLESQKL-LSQAKPKAIPNLIELSR 1515

  Fly  1832 VRRYIPKHGIQYKVWWFVTSSSFEYTIF--ILIMINTVTLAMKFYN-------QPLWYTELLDAL 1887
            ||::..:..::.|        :|.|..|  :::.::.:.|..:.||       |.:::
Yeast  1516 VRQFFYQLAVEKK--------NFYYASFLQVVLYLHIIMLLSRSYNPGNLIGYQGVYF------- 1565

  Fly  1888 NMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFI-DIVYSEIKSKDTSQIAECDIVE 1951
             |..|:||.::....:.....:.||...||.....|::.:|| :.|...:.:
Yeast  1566 -MFSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVAFHVPA------------- 1616

  Fly  1952 GCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIY 2016
                      |:....|....|.::..:.::.:.:.:..||.|.:.|...:..:.....:||.:|
Yeast  1617 ----------SHYWFHNIKGFFLLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVY 1671

  Fly  2017 AVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDT 2081
            |:...|:||...|  |:..|.|.||:|..::::||||.:.||.|..||...:.. :..|..:.::
Yeast  1672 AIALNQIFGLTRL--GSNTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVS-EPYCSSDDNS 1733

  Fly  2082 PGEPCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDW---SILGPHHLDEFIRLWSE 2142
            ....||| :.||...:|:.::..::.:|:||::|:.||.|:.|..   |.:....:.::|..||:
Yeast  1734 TYTDCGSETYAYLLLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSK 1798

  Fly  2143 YDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSD 2192
            :|.|..|.::...:..::.....||.| |:...|:..|.||...|.:|.|
Yeast  1799 FDTDGTGELELSYLPRIMHSFDGPLSF-KIWEGRLTIKSLVENYMEVNPD 1847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	85/396 (21%)
		Ion_trans	1137..1379	CDD:459842	59/264 (22%)
		Ion_trans	1496..1809	CDD:459842	78/365 (21%)
		Ion_trans	1851..2126	CDD:459842	64/288 (22%)
		GPHH	2135..2188	CDD:465306	14/52 (27%)
		Ca_chan_IQ	2198..2273	CDD:462591
CCH1	NP_011733.3	Ion_trans	<483..722	CDD:459842	52/245 (21%)
		Ion_trans	769..1010	CDD:459842	60/266 (23%)
		Ion_trans	1210..1480	CDD:459842	74/338 (22%)
		Ion_trans	1529..1776	CDD:459842	63/280 (23%)