DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1D and CCH1

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_011733.3 Gene:CCH1 / 853131 SGDID:S000003449 Length:2039 Species:Saccharomyces cerevisiae


Alignment Length:2130 Identity:413/2130 - (19%)
Similarity:764/2130 - (35%) Gaps:656/2130 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   422 NCDITGDNSTLHGFGVGDVCSFIADCDDNSEDDDGDPNNQDLSSQTLRTAAIVAAVAAAAKEQAQ 486
            |.:..|||:.:          ...:.:||||.|.   |..:...|.|...|:......::....:
Yeast    15 NTNPFGDNAAV----------MTENVEDNSETDG---NRLESKPQALVPPALNIVPPESSIHSTE 66

  Fly   487 EQSLADCESFSDRRQDADEDVRIIQDCC-----GGNNDSLE---------DVGEVDDNADVVVRK 537
            |:.       .|.....|:|..:|.:..     ..::::|.         ..|..:.:     |:
Yeast    67 EKK-------GDEYNGNDKDSSLISNIFRTRVGRSSHENLSRPKLSLKTASFGAAESS-----RR 119

  Fly   538 N-SRNRPSIRRTCRITEEDDDEDENADYGDFDREDQELDDEEPEGTTIDIDEQEQQHDQGDSAEE 601
            | |.:..|.:.:.:..:.:|:......:..:.|.........|..|  |...:..:.....:|::
Yeast   120 NVSPSTKSAKSSSQYIDLNDERLRRRSFSSYSRSSSRRVSNSPSST--DRPPRSAKVLSLIAADD 182

  Fly   602 EDDDEDVDEYFEE--EEDDTQAFSPFYSSSAELIDNFG--GGAGKFFNIMDFERGASGEGGFSPN 662
            .||.||:.:.|:.  :|:.........|..:..:.:.|  .|.|:..:|.|..         :||
Yeast   183 MDDFEDLQKGFKSAIDEEGLTWLPQLKSEKSRPVSDVGEDRGEGEQESIPDVH---------TPN 238

  Fly   663 GNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGA 727
            .......|.:..|                           ||.            .|.|..:.|.
Yeast   239 VGASATPGSIHLT---------------------------PEP------------AQNGSVSEGL 264

  Fly   728 AGQKRQQRRGKPQP-----------DRPQ-----------------------------RALFCLS 752
            .|.....|: ||.|           |:.|                             .:|...|
Yeast   265 EGSINNSRK-KPSPKFFHHLSPQKEDKDQTEVIEYAEDILDFETLQRKLESRPFVLYGHSLGVFS 328

  Fly   753 VKNPLRALCIRIVEWKPFEFL--ILLTIFANCIALAVYTPYPGSDSNV------TNQTLEKVEYV 809
            ..||||....|.:..:.:..|  .|||.:|..:|:..|.|:     ||      :|.|    :|.
Yeast   329 PTNPLRIKIARFLLHRRYSLLYNTLLTFYAILLAIRTYNPH-----NVVFLYRFSNWT----DYF 384

  Fly   810 FLVI---FTAECVMKILAYGF----------------VLHNGA------YLRN--GWNLLDFTIV 847
            ..::   ||...:.||:|:||                :|....      |||.  |..|:||.|.
Yeast   385 IFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRSGIMKLYIYLREKYGRKLIDFIIP 449

  Fly   848 --VI----------GAISTALSQ--------------------------------------LMKD 862
              :|          .::||:|::                                      |...
Yeast   450 FRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSIK 514

  Fly   863 AFDVK-ALRAFR---VLRPLRLV---SGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGL 920
            ::|.| .:|.|:   :||.||||   :|:||   :|..:...:..|.:::.::::..|.:.|:|:
Yeast   515 SYDTKTGIRIFKPLAILRILRLVNVDTGMPS---ILRGLKYGIPQLVNVSSMLVYFWIFFGILGV 576

  Fly   921 ELFSGKLHKAC----RDEITGEYEENIRPCG------------------------VGYQCPPGYK 957
            ::|.|...:.|    .::.|..|:.:::.||                        .|:.||...|
Yeast   577 QIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVTKRKQNYIYEDGSEGSVSKGFLCPQYSK 641

  Fly   958 CYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQ--WMYFISMVILGAF 1020
            |... ..|.:|..:|||...:|..||..::...:||::|...|   ||..  .::||..:.:...
Yeast   642 CVSN-ANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMD---SDEMAACLFFIVCIFVLTI 702

  Fly  1021 FVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDG 1085
            :::||::.||...|.....:.|.:......|:...:...:.||..:..             :...
Yeast   703 WLLNLLIAVLVSSFEIANEEYKKKKFIYGSRKTGYVARIVTGYWKYFK-------------LKAN 754

  Fly  1086 KGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFY----WLIIV 1146
            :.|.||                     |.:                    |..|.|    ::.::
Yeast   755 QTKFPN---------------------WSQ--------------------KGLAIYSHVEFIFVI 778

  Fly  1147 LVFLNTGVLATEHYGQLDWLDNFQEYTN-----VFFIGLFTCEML--LKMYSLGFQGYFVSLFNR 1204
            |:..:.|:.|:.........:|....|:     |.||     |.|  |.:|......:.......
Yeast   779 LIICDIGMRASVKVSTSANCNNILLKTDRGISIVLFI-----ESLARLVLYLPNMWKFLTKPSYV 838

  Fly  1205 FDCFVVIGSITETLLTNTGMMPPL--GVSVLRCVRLLRV---FKVT-KYWRSLSNLVASLLNSIQ 1263
            :|..:.|.::..:.|...|::..:  .:|:....|..||   |.:| |.|:.:      |.|.:.
Yeast   839 YDFIISIITLVISCLAVEGVLGHMYAWLSIFHISRFYRVIISFNLTKKLWKQI------LSNGVM 897

  Fly  1264 SIASLLLLLFLFIVIFALLGMQVFGGKFNFDG---KEEKYRMNFDCFW--QALLTVFQIMTGEDW 1323
             |.:|....|.|..:.|:: |.|:     |:|   .||.....|..:.  .:.|::|.|.:.|:|
Yeast   898 -IWNLSSFYFFFTFLVAII-MAVY-----FEGVIPPEEMADQPFGMYSLPNSFLSLFIIGSTENW 955

  Fly  1324 NAVMYVGINAYGGVSSYGALAC-IYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEP- 1386
            ..::|........:||  ...| ::|||.|:..|.::||:|:|:.      ::|:...|:|:.| 
Yeast   956 TDILYALQKHSPNISS--TFFCSVFFIIWFLLSNSVILNIFIALI------SESMEVKEEEKRPQ 1012

  Fly  1387 ---------HDESAQKKSHSPTPTIDGMDDHLSIDIDMEQQELD---DEDKMDHETL-------- 1431
                     :.:..|:.:|:            |:...:.::...   :||..|.:..        
Yeast  1013 QIKHYLKFVYPQKIQEYTHA------------SLVARIRKKFFGGHRNEDTRDFKQFLMRGTAIM 1065

  Fly  1432 -SDEEVREMCEEEEEVDEE------------GMITARPRRM-----------------SEVNTAT 1466
             ..:.:.|:.:|.:|...|            |:.:.:..||                 :::|..|
Yeast  1066 NIAQNMGELADEFKEPPSENLFKKGLSKLTIGVPSLKRLRMFANNPFYKNSDVVFTETNDINGRT 1130

  Fly  1467 KILPIPP---------------GTSFFLFSQTNRFRVFCHWLC---------------------- 1494
            .||.:..               ..|::.||..:|||.||..|.                      
Yeast  1131 YILELNEYEDEKLDYLKKYPLFNYSYYFFSPQHRFRRFCQRLVPPSTGKRTDGSRFFEDSTDLYN 1195

  Fly  1495 NHSNFGNI----------------ILC-CIM--------------FSSAMLAAENPLRANDDLNK 1528
            ..|.|.:|                |:| |.:              :|||:               
Yeast  1196 KRSYFHHIERDVFVFIFALATILLIVCSCYVTPLYRMHHKMGTWNWSSAL--------------- 1245

  Fly  1529 VLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLV----SSSNAIS 1589
                 |..|...|:||.|:|.::.||:....|:.|:.:|.:|..|:....|:|:    ::.|...
Yeast  1246 -----DCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCVLISMWINLIAYLKNNGNLSR 1305

  Fly  1590 VVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKC 1654
            :.|.|..||.||.|...|.|:                                   |.|..|   
Yeast  1306 IFKGLTALRALRCLTISNTAR-----------------------------------QTFNLV--- 1332

  Fly  1655 VVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTY--LVYDDGDVHKP 1717
            :...:..|....|::..|.|.|.|.|:.:|||:...|.||| :.:.:||..|  .|: ..|:..|
Yeast  1333 MFDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCNDGS-LGRADCYNEYSNSVF-QWDIMSP 1395

  Fly  1718 RLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIV-----AA 1777
            |:.::.:    .|.|..|....:|:.:.:.|||..||     .|..|...|.....::     |.
Yeast  1396 RVYQQPY----LHLDSFASAFSSLYQIISLEGWVDLL-----ENMMNSSGIGTPATVMGSAGNAL 1451

  Fly  1778 YYIIYIIIIAFFMVNIFVGFVI-----------VTFQNEGEQEYKNCDLDKNQRNCIEFALKAKP 1831
            :.:::..:...|::|:||.|::           .|.:.:...|.:.. |.:.:...|...::...
Yeast  1452 FLVLFNFLSMVFILNLFVSFIVNNQARTTGSAYFTIEEKAWLESQKL-LSQAKPKAIPNLIELSR 1515

  Fly  1832 VRRYIPKHGIQYKVWWFVTSSSFEYTIF--ILIMINTVTLAMKFYN-------QPLWYTELLDAL 1887
            ||::..:..::.|        :|.|..|  :::.::.:.|..:.||       |.:::       
Yeast  1516 VRQFFYQLAVEKK--------NFYYASFLQVVLYLHIIMLLSRSYNPGNLIGYQGVYF------- 1565

  Fly  1888 NMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFI-DIVYSEIKSKDTSQIAECDIVE 1951
             |..|:||.::....:.....:.||...||.....|::.:|| :.|...:.:             
Yeast  1566 -MFSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVAFHVPA------------- 1616

  Fly  1952 GCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIY 2016
                      |:....|....|.::..:.::.:.:.:..||.|.:.|...:..:.....:||.:|
Yeast  1617 ----------SHYWFHNIKGFFLLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVY 1671

  Fly  2017 AVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDT 2081
            |:...|:||...|  |:..|.|.||:|..::::||||.:.||.|..||...:.. :..|..:.::
Yeast  1672 AIALNQIFGLTRL--GSNTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVS-EPYCSSDDNS 1733

  Fly  2082 PGEPCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDW---SILGPHHLDEFIRLWSE 2142
            ....||| :.||...:|:.::..::.:|:||::|:.||.|:.|..   |.:....:.::|..||:
Yeast  1734 TYTDCGSETYAYLLLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSK 1798

  Fly  2143 YDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSD 2192
            :|.|..|.::...:..::.....||.| |:...|:..|.||...|.:|.|
Yeast  1799 FDTDGTGELELSYLPRIMHSFDGPLSF-KIWEGRLTIKSLVENYMEVNPD 1847

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 85/396 (21%)
Ion_trans 1137..1379 CDD:395416 59/264 (22%)
Ion_trans 1496..1809 CDD:395416 78/365 (21%)
Ion_trans 1851..2126 CDD:395416 64/288 (22%)
GPHH 2135..2188 CDD:407139 14/52 (27%)
Ca_chan_IQ 2199..2271 CDD:400901
CCH1NP_011733.3 Ion_trans <483..722 CDD:395416 52/245 (21%)
Ion_trans 769..1010 CDD:395416 60/266 (23%)
Ion_trans 1210..1480 CDD:395416 74/338 (22%)
Ion_trans 1529..1776 CDD:395416 63/280 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 91 1.000 Domainoid score I1740
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 1 0.950 - 0 Normalized mean entropy S2960
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.040

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