DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and scn8ab

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_005166128.1 Gene:scn8ab / 793996 ZFINID:ZDB-GENE-060906-2 Length:1969 Species:Danio rerio


Alignment Length:1950 Identity:476/1950 - (24%)
Similarity:821/1950 - (42%) Gaps:544/1950 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            :|:.:|..|..|.:.|:|:....|..:|:.||..||:.:....|...|         ::|||.|.
Zfish   113 SLYIISPFNLFRQIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWS---------KQVEYTFT 168

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.:.||:|.||.:.:..:||:.||.|||.::.:..|:..:     :..:|.|||.|||||
Zfish   169 GIYTFESLTKIVARGFCIDDFTFLRDPWNWLDFMVISMAYITEFV-----NLGNVSALRTFRVLR 228

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC---------- 931
            .|:.|:.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.|.:.|          
Zfish   229 ALKTVAVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVIWPVNSTET 293

  Fly   932 -----------RDEITGEYEENIRP-------CGVGY---QCPPGYKCYGGWDGPNDGITNFDNF 975
                       .:.|..:......|       ||...   :||.||.|......||.|.|:||:|
Zfish   294 YLANGSKGFDFNEYIMNDTNFYFLPGMLDALLCGNSSDSGRCPEGYTCMKAGRNPNYGYTSFDSF 358

  Fly   976 GLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSK---- 1036
            |.|.|.:|:.:|.:.|.::......|.|..:. ::|:.::.:|:|:::||||.|::..:.:    
Zfish   359 GWAFLALFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA 422

  Fly  1037 -----ERNKAKNRGDFQKLREKQQ------------------IEEDLRGYLD------------- 1065
                 |:.:|:.:...::|:::|:                  :|:|..|:|.             
Zfish   423 TIEEAEQKEAEFKAMLEQLKKQQEEAQANAMATSAGTVSEDAVEDDGGGHLSRSSSEVSKLSSKS 487

  Fly  1066 ----------W------------------------------------------------------ 1066
                      |                                                      
Zfish   488 AKERRNRKKKWRKEQEEKGDSEKVVKSESDDGSKRSRFRFRDNRLGRKASIMNQSLLSIPGSPFM 552

  Fly  1067 -----------------------ITQAED------------------------------------ 1072
                                   :.::||                                    
Zfish   553 SRRSSIFSFKGSENEFADDEHSTVEESEDRRGSLFVPYRRSSYSGYSQGSSRINPLAPHPGCKRN 617

  Fly  1073 --IEPDAVGGLISDGKGKQPNEM--------DST-------ENLGEEMPEV-QMTESRWRKMKKD 1119
              ::.:.|..||..|.|:...|:        |||       ::.|..|..| |:..|..||    
Zfish   618 STVDCNGVVSLIGPGPGRLLPEVKIDKAASDDSTTEVEGKRKHSGSLMVSVDQLNTSFSRK---- 678

  Fly  1120 FDRVNRRM--------------RRACRKA-----------------VKSQAFYWLII-------- 1145
             :|.|..|              :|.|...                 :|.:....||:        
Zfish   679 -ERANSAMTVVTNTLVEELEESQRKCPPCWYKFANTFLIWECCPIWIKIKEIVNLIVMDPFVDLA 742

  Fly  1146 --VLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCF 1208
              :.:.|||..:|.|||......:......|:.|.|:||.||..|:.::....||...:|.||.|
Zfish   743 ITICIVLNTVFMAMEHYPMTPRFEEVLSVGNLVFTGIFTAEMFAKLIAMDPYYYFQEGWNIFDGF 807

  Fly  1209 VVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLF 1273
            :|..|:.|     .|:....|:||||..|||||||:.|.|.:|:.|:..:.||:.::.:|.|:|.
Zfish   808 IVSLSLVE-----LGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 867

  Fly  1274 LFIVIFALLGMQVFGGKFNFDGKE---------EKYRMNFDCFWQALLTVFQIMTGEDWNAVMYV 1329
            :.:.|||::|||:||..:    |:         |..|.:.:.|:.:.|.||:::.|| |...|:.
Zfish   868 IIVFIFAVVGMQLFGKSY----KDCVCKIAESCELPRWHMNDFFHSFLIVFRVLCGE-WIETMWD 927

  Fly  1330 GINAYGGVSSYGALACIYFIILFICGNYILLNVFLAI-----AVDNLADADSLSE---------- 1379
            .:...|     .::..|.|:::.:.||.::||:|||:     :.||||..|...|          
Zfish   928 CMEVAG-----QSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 987

  Fly  1380 ------------------------VEKEEEPHDESAQKK-------------------------- 1394
                                    :|.|::|.|:...||                          
Zfish   988 IKKGIAWFKIHVRLLVAHVLKKKPLEDEDKPLDDMYDKKLNLMGNHTGVEIKCGDLNYPKNGNGT 1052

  Fly  1395 --------------------SHSPTPTID-----GMDD-------HLSIDIDME-QQELDDEDKM 1426
                                .|:|..|:.     |..|       ..|.:.|:| .::|||....
Zfish  1053 TSGIGSSVGKYMIDEEPMSFIHNPNLTVRVPIAVGESDFENLNTEDFSSESDVENSKDLDDTSSS 1117

  Fly  1427 DHETLS---DEEVREMCE-EEEEVDEEGMIT----ARPRRMSEVNTATKILPIPPGTS---FFLF 1480
            :..|:.   |||...:.| .||.:|.|...|    ||.:...        :||..|..   :|| 
Zfish  1118 EGSTIDIKPDEEEMAVVEVVEEYLDPEACWTDACVARYKCCD--------VPITEGWGKYWWFL- 1173

  Fly  1481 SQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENP-LRANDDLNKVLNKFDYFFTAVFTIE 1544
                  |..|:.:..|:.|..:|:..|:.||..||.|:. :.....:..:|...|..||.:|.:|
Zfish  1174 ------RKTCYLIVEHNWFETLIIFMILLSSGALAFEDVYIEQRKTIQIILEYADRVFTYIFILE 1232

  Fly  1545 LILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSSS---NAISVVKILRVLRVLRPLRA 1605
            ::||.::||||.: ..|:|     .||..:|.||::||::::   :.:..:|.||.||.||||||
Zfish  1233 MLLKWVAYGFVKYFTNAWC-----WLDFFIVDVSIVSLIANALGYSDLGPIKSLRTLRALRPLRA 1292

  Fly  1606 INRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTY 1670
            ::|.:|::.||..::.|:.:|.|::|| ||:.::                               
Zfish  1293 LSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL------------------------------- 1325

  Fly  1671 LLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGD---VHKPRLREREWSNNRFHFD 1732
                :|:::||.||.||::.|.:   .|.:|.:...:|.:..:   :......|..|.|.:.:||
Zfish  1326 ----IFSIMGVNLFAGKYYYCFN---QTAEEYFQVDVVNNKTECFALINANYTEVRWKNVKINFD 1383

  Fly  1733 DVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGF 1797
            :|..|.|.|..|:||:||..::|.::||.|....|::.....:..|::|:||..:||.:|:|:|.
Zfish  1384 NVGAGYLALLQVATFKGWMDIMYAAVDSRKVEDQPLYEDNIYMYIYFVIFIIFGSFFTLNLFIGV 1448

  Fly  1798 VIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPK--HGIQYKVWWFVTSSSFEY 1856
            :|..|..:    |.|:....:..|...|.:: .|.:|..::.||:  :.||..|:.|||..:|:.
Zfish  1449 IIDNFNQQKKKFGGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPLNKIQGMVFDFVTQQAFDI 1512

  Fly  1857 TIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDF 1921
            :|.:||.:|.||:.::..:|......:|..:|.:|...|..|||.||.|.| ..||.:.|||||.
Zfish  1513 SIMMLICLNMVTMMVETDDQSDETENILYWINFVFIVAFTGEFVLKLFALR-HYYFTNGWNVFDC 1576

  Fly  1922 IIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGE 1986
            ::|:.|.:.:..:             |::|     |......|..:  .||.|:.|:::|:...:
Zfish  1577 VVVILSIVGMFLA-------------DLIE-----KYFVSPTLFRV--IRLARIGRILRLIKGAK 1621

  Fly  1987 GIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVL 2051
            ||||||:..:.|..||..:.||:.|:.||:::.||..|..:..:.|  |....||:||..:::.|
Zfish  1622 GIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKREIG--IDDMYNFETFGNSMICL 1684

  Fly  2052 FRSATGEAWQEIMMS-CSAQPDVKCDMNSDTPGEP----CGSSIAYPYFISFYVLCSFLI-INLF 2110
            |...|...|..::.. .:..||  ||.|.:.||..    ||:.....:|...|::.|||| :|::
Zfish  1685 FMITTSAGWDGLLAPILNYPPD--CDPNKENPGTTVKGNCGNPSVGIFFFVMYIIVSFLIVVNMY 1747

  Fly  2111 VAVIMDNFDYLTRDWS-ILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 2174
            :|:|::||...|.:.: .|.....:.|..:|.::||||...|....:......:..||...|  |
Zfish  1748 IAIILENFSVATEESADPLCEDDFESFYEIWEKFDPDASQFITFAKLPDFADTLEHPLRVPK--P 1810

  Fly  2175 HRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKL 2239
            :.:   .|::|::|:.|...:.....|||..:..|.  ..|::|    .:|..:::.:...||  
Zfish  1811 NII---ELIAMDLPMVSGDRIHCLDILFAFTKRVLG--DSGDLD----MMRQQMEERFVAANP-- 1864

  Fly  2240 LDQVVPPP------GNDDEVT---VGKFYATYLIQDYF---RRFKKRK------EQEGKEGHPDS 2286
             .:|...|      ...:||:   :.:.|.::|....|   ||....|      .||.|||.|.:
Zfish  1865 -SKVSYEPITTTLRRKQEEVSAIVIQRSYRSHLASRGFICKRRPANNKLENGGGNQEKKEGTPST 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 86/314 (27%)
Ion_trans 1137..1379 CDD:395416 82/265 (31%)
Ion_trans 1496..1809 CDD:395416 94/324 (29%)
Ion_trans 1851..2126 CDD:395416 85/280 (30%)
GPHH 2135..2188 CDD:407139 13/52 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 17/83 (20%)
scn8abXP_005166128.1 Ion_trans 133..423 CDD:306908 85/304 (28%)
ARGLU <418..449 CDD:330370 4/30 (13%)
Na_trans_cytopl 503..672 CDD:314757 15/168 (9%)
Ion_trans 736..949 CDD:306908 68/227 (30%)
Na_trans_assoc 975..1178 CDD:310839 36/217 (17%)
Ion_trans 1183..1459 CDD:306908 93/319 (29%)
Na_channel_gate 1451..1503 CDD:240441 12/52 (23%)
Ion_trans 1508..1762 CDD:306908 85/278 (31%)
GPHH 1766..1829 CDD:318993 16/67 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.950

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