DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Scn9a

DIOPT Version :10

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_579823.1 Gene:Scn9a / 78956 RGDID:69368 Length:1984 Species:Rattus norvegicus


Alignment Length:1992 Identity:499/1992 - (25%)
Similarity:847/1992 - (42%) Gaps:571/1992 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.||..:|||.:.|:|:....|..||:.||..|||.:.:..|         .:..:.|||.|.
  Rat   105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTLSNP---------PEWTKNVEYTFT 160

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||||.||.:....:||:.||.|||.::|...::..:     :..:|.|||.|||||
  Rat   161 GIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFV-----NLGNVSALRTFRVLR 220

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKL-HKACRDEI----- 935
            .|:.:|.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.| ||..|.|:     
  Rat   221 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKELEENET 285

  Fly   936 ------TGEYEENIRP-------------CGVGY---QCPPGYKCYGGWDGPNDGITNFDNFGLA 978
                  |.|.||.::.             ||...   |||.||.|......|:.|.|:||.|..|
  Rat   286 LESIMNTAESEEELKKYFYYLEGSKDALLCGFSTDSGQCPEGYICVKAGRNPDYGYTSFDTFSWA 350

  Fly   979 MLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGV-------------- 1029
            .|.:|:.:|.:.|.::......|.|..:. ::|:.::.||:|:::||||.|              
  Rat   351 FLALFRLMTQDYWENLYQQTLRAAGKTYM-IFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIE 414

  Fly  1030 -----------------------------------------------------LSGEFSKE-RNK 1040
                                                                 ||.:.:|| ||:
  Rat   415 EAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEFTSIGRSRIMGLSESSSETSRLSSKSAKERRNR 479

  Fly  1041 AK----------NRGDFQKL------------------------REKQ-----QIEEDLRGYL-- 1064
            .|          .:||.:||                        |||:     |....:||.|  
  Rat   480 RKKKKQKMSSGEEKGDDEKLSKSGSEESIRKKSFHLGVEGHHRTREKRLSTPNQSPLSIRGSLFS 544

  Fly  1065 ------------------------------------------------------DWITQAEDIEP 1075
                                                                  ..|:||....|
  Rat   545 ARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSPP 609

  Fly  1076 ---------DAV--GGLIS--DGKG--KQPNEMDSTENLGEEMPEV-----------QMTESRWR 1114
                     .||  .|::|  ||..  ..||        |:.:|||           ...:.|.:
  Rat   610 VLPVNGKMHSAVDCNGVVSLVDGPSALMLPN--------GQLLPEVIIDKATSDDSGTTNQMRKK 666

  Fly  1115 KMKKDF----DRVN---RRMRRACRKAVKSQAF----------------------------YWL- 1143
            ::...:    |.:|   .|.|...|.::.:...                            ||: 
  Rat   667 RLSSSYFLSEDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHTFLIWNCSPYWIK 731

  Fly  1144 -----------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYS 1191
                             |.:.:.|||..:|.||:...:...|.....|:.|.|:|..||:||:.:
  Rat   732 FKKLIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAVGNLIFTGIFAAEMVLKLIA 796

  Fly  1192 LGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVA 1256
            :....||...:|.||..:|..|:.|..|.:..     |:||||..|||||||:.|.|.:|:.|:.
  Rat   797 MDPYEYFQVGWNIFDSLIVTLSLIELFLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIK 856

  Fly  1257 SLLNSIQSIASLLLLLFLFIVIFALLGMQVFGG-------KFNFDGKEEKYRMNFDCFWQALLTV 1314
            .:.||:.::.:|.|:|.:.:.|||::|||:||.       |.|.|.|..::.||  .|:.:.|.|
  Rat   857 IIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHMN--DFFHSFLIV 919

  Fly  1315 FQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSE 1379
            |:::.|| |...|:..:...|     ..:..|.::::.:.||.::||:|||:.:.:.: :|:|:.
  Rat   920 FRVLCGE-WIETMWDCMEVAG-----QTMCLIVYMMVMVIGNLVVLNLFLALLLSSFS-SDNLTA 977

  Fly  1380 VEKEEEPH------------------------------------------DESAQKKSHSPTPTI 1402
            :|::.:.:                                          |.:.:|:::....|:
  Rat   978 IEEDTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKGSKDTKRTADPNNKKENYISNRTL 1042

  Fly  1403 DGMD-DHLSID----IDMEQQELDDE--DKMDHETL----------------SDEEVREMCEEEE 1444
            ..|. ||..:.    |......||..  |:.|:::.                ||.|:  |..||.
  Rat  1043 AEMSKDHNFLKEKDRISGYGSSLDKSFMDENDYQSFIHNPSLTVTVPIAPGESDLEI--MNTEEL 1105

  Fly  1445 EVDEEGMITARPR-RMSEVNTATKILPIP--------------PGTSF-------FLFSQTN--- 1484
            ..|.:...:...| |.|....:|...|:|              |...|       |...|.|   
  Rat  1106 SSDSDSDYSKEKRNRSSSSECSTVDNPLPGEEEAEAEPVNADEPEACFTDGCVRRFPCCQVNVDS 1170

  Fly  1485 -------RFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVF 1541
                   ..|..|:.:..||.|.:.|:..|:.||..||.|: .:.....:..:|...|..||.:|
  Rat  1171 GKGKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIF 1235

  Fly  1542 TIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSSS---NAISVVKILRVLRVLRP 1602
            .:|::||.::||:..: ..|:|     .||.|:|.|||::||:::   :.:..:|.||.||.|||
  Rat  1236 ILEMLLKWVAYGYKTYFTNAWC-----WLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRP 1295

  Fly  1603 LRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIML 1667
            |||::|.:|::.||..:|.|:.:|.|::|| ||:.::                            
  Rat  1296 LRALSRFEGMRVVVNALIGAIPSIMNVLLV-CLIFWL---------------------------- 1331

  Fly  1668 VTYLLQFMFAVIGVQLFKGKFFKC---TDGSKM------TQDECYGTYLVYDDGDVHKPRLRERE 1723
                   :|:::||.||.|||::|   ||||:.      .:.||:.  |:...|:|        .
  Rat  1332 -------IFSIMGVNLFAGKFYECVNTTDGSRFPTSQVANRSECFA--LMNVSGNV--------R 1379

  Fly  1724 WSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAF 1788
            |.|.:.:||:|..|.|:|..|:||:||..::|.::||...|..|.:.:...:..|::|:||..:|
  Rat  1380 WKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNEQPKYEYSLYMYIYFVIFIIFGSF 1444

  Fly  1789 FMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYK--VWW 1847
            |.:|:|:|.:|..|..:    |.|:....:..|...|.:: .|.:|..::.||:.|.:::  ::.
  Rat  1445 FTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPGNKFQGCIFD 1508

  Fly  1848 FVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYF 1912
            .||:.:|:.||.:||.:|.||:.::...|..:...:|..:||:|..:|..|.|.||.:.| ..||
  Rat  1509 LVTNQAFDITIMVLICLNMVTMMVEKEGQTEYMDYVLHWINMVFIILFTGECVLKLISLR-HYYF 1572

  Fly  1913 GDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFF---RLFR 1974
            ...||:|||::|:.|.:.:..:|:..|                       ..:|...|   ||.|
  Rat  1573 TVGWNIFDFVVVILSIVGMFLAEMIEK-----------------------YFVSPTLFRVIRLAR 1614

  Fly  1975 VMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANN 2039
            :.|:::|:...:||||||:..:.|..||..:.||:.|:.||||:.||..|..:..:.|  |....
  Rat  1615 IGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAG--INDMF 1677

  Fly  2040 NFQTFQQAVLVLFRSATGEAWQEIMMSC--SAQPDVKCDMNSDTPGE----PCGS-SIAYPYFIS 2097
            ||:||..:::.||:..|...|..::...  ||.||  ||.....||.    .||: |:...||:|
  Rat  1678 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPD--CDPKKVHPGSSVEGDCGNPSVGIFYFVS 1740

  Fly  2098 FYVLCSFLIINLFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLR 2161
            :.::...:::|:::|||::||...|.: ...|.....:.|..:|.::||||...|:...:.....
  Rat  1741 YIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAA 1805

  Fly  2162 KISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRA 2226
            .:.|||...|  |:::   :|::|::|:.|...:.....|||..:..|.  ..|.:|    .||:
  Rat  1806 ALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVLG--EGGEMD----SLRS 1859

  Fly  2227 TIKQIWKRTNPKLLDQVVPPP------GNDDEVTVGKFYATYLIQDYFRRFKKRKEQEG------ 2279
            .:::.:...||   .:|...|      ...:||:     || :||..:||::.|:..:.      
  Rat  1860 QMEERFMSANP---SKVSYEPITTTLKRKQEEVS-----AT-IIQRAYRRYRLRQHVKNISSIYI 1915

  Fly  2280 KEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPE 2321
            |:|..|.:.              |..:..:..|::| :..||
  Rat  1916 KDGDRDDDL--------------PNKEDTVFDNVNE-NSSPE 1942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:459842 98/370 (26%)
Ion_trans 1137..1379 CDD:459842 81/294 (28%)
Ion_trans 1496..1809 CDD:459842 102/330 (31%)
Ion_trans 1851..2126 CDD:459842 87/285 (31%)
GPHH 2135..2188 CDD:465306 14/52 (27%)
Ca_chan_IQ 2198..2273 CDD:462591 20/80 (25%)
Scn9aNP_579823.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55
I. /evidence=ECO:0000305 112..410 97/312 (31%)
Ion_trans 125..410 CDD:459842 92/299 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..542 17/80 (21%)
Na_trans_cytopl 534..693 CDD:463401 25/166 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..609 3/32 (9%)
II. /evidence=ECO:0000305 725..988 82/276 (30%)
Ion_trans 742..955 CDD:459842 70/225 (31%)
Na_trans_assoc 981..1185 CDD:461936 31/205 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1040 2/24 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1145 9/41 (22%)
III. /evidence=ECO:0000305 1178..1486 107/359 (30%)
Ion_trans 1189..1464 CDD:459842 101/325 (31%)
Na_channel_gate 1456..1508 CDD:240441 10/52 (19%)
IV. /evidence=ECO:0000305 1495..1793 99/325 (30%)
Ion_trans 1512..1768 CDD:459842 87/283 (31%)
IQ 1886..1908 CDD:197470 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1984 8/42 (19%)
Blue background indicates that the domain is not in the aligned region.

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