DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1D and CACNA1S

DIOPT Version :10

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_000060.2 Gene:CACNA1S / 779 HGNCID:1397 Length:1873 Species:Homo sapiens


Alignment Length:1971 Identity:1026/1971 - (52%)
Similarity:1290/1971 - (65%) Gaps:233/1971 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   732 RQQRRGKPQPD---RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPG 793
            |:::..||.|:   ||.||||||:::||||..||.||||||||.:|||||||||:|||||.|.|.
Human    12 RKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPE 76

  Fly   794 SDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQ 858
            .|:|..|..|||:||.||::|:.|..|||:||||:.|..||||:|||:||||||.:|..:..|.|
Human    77 DDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQ 141

  Fly   859 L-----------MKDA-FDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFV 911
            :           .|.| .||||||||||||||||||||||||||||||.|||:|||||||||||:
Human   142 VNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFM 206

  Fly   912 IIIYAIIGLELFSGKLHKAC----RDEITGEYEENIRPC---GVGYQCP-PGYKCYGGWDGPNDG 968
            :|||||||||||.||:||.|    .|.:.....|...||   |.|.:|. .|.:|.|||.|||.|
Human   207 VIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHG 271

  Fly   969 ITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGE 1033
            ||:|||||.:||||:||:|:||||||||.:.||:|::|.|:||:::::||:||::||:|||||||
Human   272 ITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGE 336

  Fly  1034 FSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAE--DIEPDAVGGLISDGKGKQPNEMDST 1096
            |:|||.|||:||.|||||||||::||||||:.||||.|  |:|....|.|..|..|.....:...
Human   337 FTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEI 401

  Fly  1097 ENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYG 1161
            ..|.:.:..::    .||:.       ||..|..|...|||:.||||:|::|.|||..:|:||:.
Human   402 AGLNKIIQFIR----HWRQW-------NRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHN 455

  Fly  1162 QLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMP 1226
            |..||...|:..|...:.|||.|||:|||.||.:.||:|:|||||||||...|.|.||..:|.|.
Human   456 QPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520

  Fly  1227 PLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKF 1291
            |||:|||||:||||:||:||||.|||||||||||||:||||||||||||||||||||||:|||::
Human   521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY 585

  Fly  1292 NFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGN 1356
            :|:..|.: |.|||.|.|||::|||::|||||.::||.||.||||.|..|.|.||||||||:|||
Human   586 DFEDTEVR-RSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGN 649

  Fly  1357 YILLNVFLAIAVDNLADADSLSEVEK---EEEPH--------DESAQKKSH-----SPTPTIDGM 1405
            ||||||||||||||||:|:||:..:|   ||:..        |:|.::||.     ...|..:|:
Human   650 YILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGI 714

  Fly  1406 DDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILP 1470
            .....:.||..:..:       :|........:...::||.:.|..::.|||.::|:....|.:|
Human   715 PTTAKLKIDEFESNV-------NEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVP 772

  Fly  1471 IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDY 1535
            ||..:|||:||.||:.||.||.:.|.:.|.|.||..|:.|||.||||:|:||:...|::|..||.
Human   773 IPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDI 837

  Fly  1536 FFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVL 1600
            .||:|||:|::||:.:||..||.|:|||:.||:||||||.|||||:...|:||||||||||||||
Human   838 GFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVL 902

  Fly  1601 RPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNI 1665
            ||||||||||||||||||:.||:.|||||||||.|||||||            |           
Human   903 RPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFA------------C----------- 944

  Fly  1666 MLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFH 1730
                         |||||||||||:|||.||||::||.|.|.||.|||..:..||.|||.::.||
Human   945 -------------IGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFH 996

  Fly  1731 FDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFV 1795
            ||:|...|::|||||||||||.|||.:||||.|:.|||:|.|..:|.::|||||:|||||:||||
Human   997 FDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFV 1061

  Fly  1796 GFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFI 1860
            ||||||||.:||.|||||:||||||.|:::||||:|:|.||||:..||:||:.||||.|||.:|.
Human  1062 GFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFA 1126

  Fly  1861 LIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVL 1925
            |||:||:.|.|:.|||......:.|.||:.||.:|.||.:.||.||:.:.||||.||||||:||:
Human  1127 LIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVI 1191

  Fly  1926 GSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRT 1990
            ||.||::.|||.:...|......:..||.:......:. ||..||||||||||:||||:.||:||
Human  1192 GSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESAR-ISSAFFRLFRVMRLIKLLSRAEGVRT 1255

  Fly  1991 LLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSA 2055
            ||||||||||||||||||||:|||||||:|||:||||||..|..|..|||||||.||||:|||.|
Human  1256 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA 1320

  Fly  2056 TGEAWQEIMMSCSAQPDVKCDMNSD-TPGE--PCGSSIAYPYFISFYVLCSFLIINLFVAVIMDN 2117
            ||||||||:::||.  ...||..|| .|||  .||::.||.||||||:||:||:|||||||||||
Human  1321 TGEAWQEILLACSY--GKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDN 1383

  Fly  2118 FDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRL 2182
            |||||||||||||||||||..:|:||||:|||||||||||||||:|.|||||||.||||:|||||
Human  1384 FDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRL 1448

  Fly  2183 VSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPP 2247
            |.|||||||||||.|||||||:|||:|.|||:||.:.||.||||.||:|||||:.||||||:||.
Human  1449 VGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPI 1513

  Fly  2248 GNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGH-PDSNTVTLQAGLRTL-HEVSPALKRAIS 2310
            | ||||||||||||:|||::||:|.||  ||...|: |..:.|.:||||||: .|.:|.:.|.:|
Human  1514 G-DDEVTVGKFYATFLIQEHFRKFMKR--QEEYYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVS 1575

  Fly  2311 GNL---DELDQE------PEPMHRRHHTLFGSVWSSIRRHG-----------------------N 2343
            |:|   :||::.      .|.:.||...|||.|.:.:.|..                       :
Human  1576 GDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEIEMEEMES 1640

  Fly  2344 GTF--------RRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVA 2400
            ..|        |.:..|.|:.:|.                                    |.:||
Human  1641 PVFLEDFPQDPRTNPLARANTNNA------------------------------------NANVA 1669

  Fly  2401 DGVNNITRNIMQARLAAAGKLQDELQ-----GAGSGGELRTFGESISMRPLAKNGGGAAT----V 2456
            .|.:|.:.:.:.:.:....:..:|.:     |...|...|..|.  ..:|..:...|..|    .
Human  1670 YGNSNHSNSHVFSSVHYEREFPEETETPATRGRALGQPCRVLGP--HSKPCVEMLKGLLTQRAMP 1732

  Fly  2457 AGTLPPEANAINYDNRNRGILLHPYNNVYAP------NGALPGHERMIQSTPAS-----PYDQRR 2510
            .|..||                       ||      ..::|  |....|||.|     |:.:..
Human  1733 RGQAPP-----------------------APCQCPRVESSMP--EDRKSSTPGSLHEETPHSRST 1772

  Fly  2511 LPTSSDMNGLAES-LIGGVLAAEGLGKY-CDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEH 2573
            ...:|..:..|.: ||...|...|||.. .|:.|:....:.:.:|..|.|||:.:.|.::|....
Human  1773 RENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKGRE 1837

  Fly  2574 SLSLIGSSNGSI-FGGSAGGL 2593
            :...:.||.|.: .|.|.|.|
Human  1838 APEGMASSLGCLNLGSSLGSL 1858

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:459842 182/294 (62%)
Ion_trans 1137..1379 CDD:459842 162/241 (67%)
Ion_trans 1496..1809 CDD:459842 187/312 (60%)
Ion_trans 1851..2126 CDD:459842 172/277 (62%)
GPHH 2135..2188 CDD:465306 42/52 (81%)
Ca_chan_IQ 2198..2273 CDD:462591 55/74 (74%)
CACNA1SNP_000060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 4/10 (40%)
I. /evidence=ECO:0000305 38..337 185/298 (62%)
Ion_trans 50..345 CDD:459842 182/294 (62%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 1/2 (50%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 12/16 (75%)
II. /evidence=ECO:0000305 418..664 162/246 (66%)
Ion_trans 431..672 CDD:459842 162/241 (67%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..717 9/41 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 4/25 (16%)
Interaction with STAC, STAC2 and STAC3 (via SH3 domains). /evidence=ECO:0000269|PubMed:29078335 747..760 4/12 (33%)
III. /evidence=ECO:0000305 786..1068 188/317 (59%)
Ion_trans 798..1075 CDD:459842 187/312 (60%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 59/88 (67%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 2/2 (100%)
IV. /evidence=ECO:0000305 1105..1384 170/281 (60%)
Ion_trans 1117..1392 CDD:459842 172/277 (62%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 50/65 (77%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 31/41 (76%)
GPHH 1401..1454 CDD:465306 42/52 (81%)
Ca_chan_IQ 1464..1536 CDD:462591 54/72 (75%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:19473981 1522..1542 14/21 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1731..1780 13/73 (18%)

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