DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1D and CACNA1F

DIOPT Version :9

Sequence 1:	NP_723952.2	Gene:	Ca-alpha1D / 34950	FlyBaseID:	FBgn0001991	Length:	2705	Species:	Drosophila melanogaster
Sequence 2:	NP_005174.2	Gene:	CACNA1F / 778	HGNCID:	1393	Length:	1977	Species:	Homo sapiens

Alignment Length:	2129	Identity:	1072/2129 - (50%)
Similarity:	1306/2129 - (61%)	Gaps:	378/2129 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   653 ASGEGGF------SPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTI 711
            :..|||.      ||....|||                                  ||.  |...
Human     2 SESEGGKDTTPEPSPANGAGPG----------------------------------PEW--GLCP 30

  Fly   712 GPSGAGGQKGGAAAGAAGQKRQQRRGK------PQPDRPQRALFCLSVKNPLRALCIRIVEWKPF 770
            ||....|:..| |:|....||:.:..|      ....|..||||||::.||||..||.|||||||
Human    31 GPPAVEGESSG-ASGLGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPF 94

  Fly   771 EFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYL 835
            :.||||||||||:||.||.|:|..|||..|..||:||||||||||.|.|:||:|||.|||..||:
Human    95 DILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYI 159

  Fly   836 RNGWNLLDFTIVVIGAISTALSQ---LMKDA---------FDVKALRAFRVLRPLRLVSGVPSLQ 888
            |||||||||.|||:|..|..|.|   ...||         ||||||||||||||||||||||||.
Human   160 RNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLH 224

  Fly   889 VVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITG---EYEENIRPC---G 947
            :|||||:||:|||.|||||||||||||||||||||.|::||.|  ...|   |.||:..||   |
Human   225 IVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTC--YFLGSDMEAEEDPSPCASSG 287

  Fly   948 VGYQCPPGY-KCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYF 1011
            .|..|.... :|.|.|.|||.||||||||..||||||||||:||||||||.:|||||.:..|:||
Human   288 SGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYF 352

  Fly  1012 ISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIE-- 1074
            :|:||.|:|||:||:||||||||||||.|||.||||||.|||||:|||||||||||||||:::
Human   353 VSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDME 417

  Fly  1075 ----PDAVGGLISDGK-GKQPN--EMDS---------------------------------TENL 1099
                .|.:|.:..:|: |.:|.  |:.:                                 ||..
Human   418 DPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQ 482

  Fly  1100 GEEMPEVQMTESRWRKMKKDF-DRVNRRMRRA-------CRKAVKSQAFYWLIIVLVFLNTGVLA 1156
            |:|..|.....|..|.:.|.. .||.||:|||       ||:||||.|.||.:::||||||..:|
Human   483 GDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIA 547

  Fly  1157 TEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTN 1221
            :||:||..||...|||.|...:.|||.|||||:|.||...|..|.|||||||||.|.|.||.|..
Human   548 SEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVE 612

  Fly  1222 TGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQV 1286
            .|.|.|||:||||||||||:||||::|.||||||||||||::|||||||||||||:||:|||||:
Human   613 VGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQL 677

  Fly  1287 FGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIIL 1351
            ||||||||....| |..||.|.|||||||||:||||||.|||.||.||||....|.|.|||||||
Human   678 FGGKFNFDQTHTK-RSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIIL 741

  Fly  1352 FICGNYILLNVFLAIAVDNLADADS-----------------------LSEVEKEEEPHDESAQK 1393
            |||||||||||||||||||||..|:                       :..||||||   |.|::
Human   742 FICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEKDLPQENEGLVPGVEKEEE---EGARR 803

  Fly  1394 KSHSPTPTIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRR 1458
            :.                 .|||::|.::|                 |||||.:|||  ......
Human   804 EG-----------------ADMEEEEEEEE-----------------EEEEEEEEEG--AGGVEL 832

  Fly  1459 MSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRAN 1523
            :.||....|::|||.|::||..||||..|..||.|.:|..|.|:||..|:.||..||||:|:||:
Human   833 LQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAH 897

  Fly  1524 DDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAI 1588
            ...|.:|..|||.||::||:|::||:..:|..||.|:||||.||:||||||.|||||....|:||
Human   898 SFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAI 962

  Fly  1589 SVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVK 1653
            |||||||||||||||||||||||||||||||.
Human   963 SVVKILRVLRVLRPLRAINRAKGLKHVVQCVF--------------------------------- 994

  Fly  1654 CVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPR 1718
               |||:||||||:||.|||||||.||||||||||:.|||.:|.|..||.|::|||.||||.:|.
Human   995 ---VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPL 1056

  Fly  1719 LREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYI 1783
            :|||.|.|:.|:||:|...|:.|||||||||||.|||.:||:..|:.|||:|:|..::.::|:||
Human  1057 VRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYI 1121

  Fly  1784 IIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWF 1848
            |||||||:||||||||:||:.:|||||:||:||||||.|:|:||||:|:||||||:..||:||..
Human  1122 IIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWAT 1186

  Fly  1849 VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFG 1913
            |.|::|||.:|:||::|||.|||:.|.|...:...:|.|||:||.:|.:|.|.|:.||:.|:||.
Human  1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFT 1251

  Fly  1914 DAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRL 1978
            ||||.||.:||:||.:||..:|:.:             |....:.|..|:.|||.||||||||||
Human  1252 DAWNTFDALIVVGSIVDIAVTEVNN-------------GGHLGESSEDSSRISITFFRLFRVMRL 1303

  Fly  1979 VKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQT 2043
            |||||||||||||||||||||||||||||||.::||||||:|||:|||:||..|..|..||||||
Human  1304 VKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQT 1368

  Fly  2044 FQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSD-TPGE--PCGSSIAYPYFISFYVLCSFL 2105
            |.||||:|||.||||||||||:  ::.|..:||..|| .|||  .|||:.|..|||||::||:||
Human  1369 FPQAVLLLFRCATGEAWQEIML--ASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFL 1431

  Fly  2106 IINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFG 2170
            |||||||||||||||||||||||||||||||.|:||||||.|||||||||||.|||:|.||||||
Human  1432 IINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFG 1496

  Fly  2171 KLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRT 2235
            ||||||:||||||:|||||||||||.|||||||:|||||.|||:||::.||.|||..||:||||.
Human  1497 KLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRM 1561

  Fly  2236 NPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQE--GKEGHPDSNTVTLQAGLRTL 2298
            ..||||:|:||| :::||||||||||:|||||||:|::|||:.  |.:..| |.:..||||||:|
Human  1562 KQKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAP-STSSALQAGLRSL 1624

  Fly  2299 HEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAI 2363
            .::.|.:::|::.:.:|.::|.:              ..:..........:.....||.:...
Human  1625 QDLGPEMRQALTCDTEEEEEEGQ--------------EGVEEEDEKDLETNKATMVSQPSARR-- 1673

  Fly  2364 GGSASAALGVGG---SSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDEL 2425
            |...|.:|.||.   .||..|.||...|                  |....|..:..||   ...
Human  1674 GSGISVSLPVGDRLPDSLSFGPSDDDRG------------------TPTSSQPSVPQAG---SNT 1717

  Fly  2426 QGAGSGGELRTFGESISMRPLAKNGGGAATVAGTLPPEANAINYDNRNRG-----ILLHPYNNVY 2485
            ...|||..:.|..|..:.:|....|.........:|   :.::|.:...|     :||.|:....
Human  1718 HRRGSGALIFTIPEEGNSQPKGTKGQNKQDEDEEVP---DRLSYLDEQAGTPPCSVLLPPHRAQR 1779

  Fly  2486 APNGALPGHERMIQSTP------------------------------------------ASPYDQ 2508
            ..:|.|....|::..||                                          |:|..:
Human  1780 YMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQGSCEDLPIPGTYHRGRNSGPNRAQGSWATPPQR 1844

  Fly  2509 RRL----------------------------------PTSSD----MNGLAESLIGGVLAAEGLG 2535
            .||                                  .|.||    ..|.|:||:..||.:||||
Human  1845 GRLLYAPLLLVEEGAAGEGYLGRSSGPLRTFTCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLG 1909

  Fly  2536 KYC-DSEFVGTAAREMREALDMTPEEMNLAAHQIL--------SNEHSL 2575
            .:. |..||..|.:|:.:|..:|.:||:.||..:|        |:|.|:
Human  1910 LFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESI 1958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	196/293 (67%)
		Ion_trans	1137..1379	CDD:395416	168/264 (64%)
		Ion_trans	1496..1809	CDD:395416	180/312 (58%)
		Ion_trans	1851..2126	CDD:395416	170/277 (61%)
		GPHH	2135..2188	CDD:407139	44/52 (85%)
		Ca_chan_IQ	2199..2271	CDD:400901	51/71 (72%)
CACNA1F	NP_005174.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60		20/94 (21%)
		I	79..375		198/297 (67%)
		Ion_trans	109..383	CDD:278921	181/275 (66%)
		Binding to the beta subunit. /evidence=ECO:0000250	395..412		15/16 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..441		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..488		4/32 (13%)
		II	515..761		169/246 (69%)
		Ion_trans	546..763	CDD:278921	156/217 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..830		21/101 (21%)
		III	858..1140		181/317 (57%)
		Ion_trans	888..1107	CDD:278921	147/254 (58%)
		Dihydropyridine binding. /evidence=ECO:0000250	1060..1150		55/89 (62%)
		IV	1177..1444		167/281 (59%)
		Ion_trans	1207..1452	CDD:278921	160/259 (62%)
		Dihydropyridine binding. /evidence=ECO:0000250	1397..1463		50/65 (77%)
		Phenylalkylamine binding. /evidence=ECO:0000250	1409..1452		32/42 (76%)
		GPHH	1460..1523	CDD:293510	54/62 (87%)
		Ca_chan_IQ	1525..1596	CDD:285917	51/71 (72%)
		CAC1F_C	1620..1974	CDD:293490	75/379 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1637..1754		27/156 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1816..1841		1/24 (4%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I825
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1991	1.000	Inparanoid score	I55
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48156
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	1	1.000	-	-		otm41149
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X533
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.980