DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and CACNA1E

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_016857732.1 Gene:CACNA1E / 777 HGNCID:1392 Length:2458 Species:Homo sapiens


Alignment Length:2553 Identity:865/2553 - (33%)
Similarity:1197/2553 - (46%) Gaps:696/2553 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   586 IDEQEQQHDQGDSAEEEDDDEDV-------------DEYFEEEEDDTQAF----------SPFYS 627
            :.|:|....|..:..|.|..::|             |.:|:.:|.:.|.:          |||..
Human    41 LPEEEAWRPQQCALLEADASDEVGMLPASPRAASGFDNFFQVQEGEGQGWEGAMALEAGSSPFLP 105

  Fly   628 SSAELIDNFGGGAGKFFNIM-----------------DFERGASGEGGFSPNGNGGPGSGDVSRT 675
            .|.|::....||..:..:|:                 ::|....||                :..
Human   106 VSPEVMKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGE----------------AVV 154

  Fly   676 ARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQ 740
            ||..||:||.....|..|.                  |..|.||........|.:.|......|.
Human   155 ARPGSGDGDSDQSRNRQGT------------------PVPASGQAAAYKQTKAQRARTMALYNPI 201

  Fly   741 PDRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTN 800
            |.|.     .|:||.....|.:|....::::|.|||::||.||.||||.||:....|..|....:
Human   202 PVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMS 266

  Fly   801 QTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFD 865
            :.|||.|..|:.||..|..:||:|.||:.|.|:|||||||::||.:|:.|.::||.:. .....|
Human   267 RRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTH-FNTHVD 330

  Fly   866 VKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKA 930
            ::.|||.||||||:||||:||||:||.||:||||||..|.||:.|.|:::||||||.:|||||:|
Human   331 LRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRA 395

  Fly   931 CRDEITGEYE--ENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTD 993
            |....:|..|  :...|||| ..||.||:| ..|.|||||||.|||...|:||||||:|:||||.
Human   396 CFMNNSGILEGFDPPHPCGV-QGCPAGYEC-KDWIGPNDGITQFDNILFAVLTVFQCITMEGWTT 458

  Fly   994 VLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEE 1058
            |||:..||:|:.|.|:|||.::|:|:|||:||:||||||||:|||.:.:||..|.|||.:||||.
Human   459 VLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIER 523

  Fly  1059 DLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKD---- 1119
            :|.||..||.:||::       :::     :.|:...|..| |.:....:..||...|.:|    
Human   524 ELNGYRAWIDKAEEV-------MLA-----EENKNAGTSAL-EVLRRATIKRSRTEAMTRDSSDE 575

  Fly  1120 ---------------------------FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLAT 1157
                                       |....|.:|.:.|..||||.|||:::.||.|||..:|.
Human   576 HCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAI 640

  Fly  1158 EHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNT 1222
            .|:.|..||.:...|....|:|||..||.||||.:|.:.||.|.||.||..|.:|||.|.:....
Human   641 VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIF 705

  Fly  1223 GMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVF 1287
            ......|:||||.:||||:||:||||.||.|||.||::|::||.|||.|||||||:|||||||:|
Human   706 RPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLF 770

  Fly  1288 GGKFNF-DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIIL 1351
            ||:||| ||...   .|||.|..|::|||||:||||||.|||.||.:.||||| |..:.||||:|
Human   771 GGRFNFNDGTPS---ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIYFIVL 831

  Fly  1352 FICGNYILLNVFLAIAVDNLADADSLSEVEKEEE-----------------------PHDESAQK 1393
            .:.|||.||||||||||||||:|..|::.|:|||                       |..|..::
Human   832 TLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRR 896

  Fly  1394 KSH-----------------------------------------------SPT------------ 1399
            :.|                                               :||            
Human   897 RRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSS 961

  Fly  1400 -------PTI--------------------------------DGMDDHLSID------------- 1412
                   |::                                ||.|...::|             
Human   962 LNPLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREP 1026

  Fly  1413 ----------IDMEQQE------------------------------------------------ 1419
                      .|..|||                                                
Human  1027 PWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQER 1091

  Fly  1420 -LDD----EDKMDHE----------TLSDEEVRE------------------------------- 1438
             ||:    |.:.|||          |:.:|..::                               
Human  1092 SLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHP 1156

  Fly  1439 ---------MCEEEEEVDEE----------------------GMITAR-PRRMSEVNTATKILP- 1470
                     :.|:|.|...|                      ..|||. .:..:|..:.|..:| 
Human  1157 ELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPD 1221

  Fly  1471 --------------------------------------------------IPPGTSFFLFSQTNR 1485
                                                              :.|.:|.|:||.||.
Human  1222 VDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNP 1286

  Fly  1486 FRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLI 1550
            .|..||::.|...|...||..|..||..||||:|:..|.:.||||..|||.||.|||.|:::|:|
Human  1287 IRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMI 1351

  Fly  1551 SYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNA--------ISVVKILRVLRVLRPLRAIN 1607
            ..|.:|.||::.|..:|:||.:||..:|::. :.:||        |..:|.||||||||||:.|.
Human  1352 DQGLILQDGSYFRDLWNILDFVVVVGALVAF-ALANALGTNKGRDIKTIKSLRVLRVLRPLKTIK 1415

  Fly  1608 RAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLL 1672
            |...||.|..                                    |||.::|.:.||::|..|.
Human  1416 RLPKLKAVFD------------------------------------CVVTSLKNVFNILIVYKLF 1444

  Fly  1673 QFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKG 1737
            .|:||||.|||||||||.|||.||.|:.||.|.|:   |.:.:|..::.|||..:.||:|::...
Human  1445 MFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYV---DHEKNKMEVKGREWKRHEFHYDNIIWA 1506

  Fly  1738 MLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF 1802
            :||||||||.||||.:|..|:|..:|:.||..:.|..::.:|::|.::..||.|||||..:|:||
Human  1507 LLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1571

  Fly  1803 QNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMIN 1865
            |.:|::..:.|.|:||:|.||:||:.|||:.||:|  :|..||:||.||.|.||||||..:|.:|
Human  1572 QEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALN 1636

  Fly  1866 TVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFID 1930
            ||.|.||:|:.|..|...|..||:.||.||:||.|.|:.||.|.|||.|.||:||||.|:||..:
Human  1637 TVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITE 1701

  Fly  1931 IVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTF 1995
            |:.::.|..:||                  |.|:   :|.:|||..||:|||.:|..||.|||||
Human  1702 IILTDSKLVNTS------------------GFNM---SFLKLFRAARLIKLLRQGYTIRILLWTF 1745

  Fly  1996 IKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAW 2060
            ::||:|||||.|||.:||||||::||||||.|.||..:.|..:|||::|..::::||||||||||
Human  1746 VQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAW 1810

  Fly  2061 QEIMMSCSAQPDVKCDMNSDTP-----GEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDY 2120
            ||||:||..:..  |:.::..|     .|.||:.:||.||:||...||||::|||||||||||:|
Human  1811 QEIMLSCLGEKG--CEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEY 1873

  Fly  2121 LTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSM 2185
            ||||.|||||||||||:|:|:|||..|.|||.:.::..:|..:|||||.||.||.::|.||||.|
Human  1874 LTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLM 1938

  Fly  2186 NMPLNSDGTVLFNATLFAVVRTSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLLDQVVPPP 2247
            |||:..|.||.|.:||.|::||:|.|| ..|..|  ..:|||:.....||...:.|:||.:||.|
Human  1939 NMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMP 2003

  Fly  2248 GNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSP-ALKRAISG 2311
            ...| :||||.||..:|.||:::.|.:|:::..|.         |........:.| :|.:.|..
Human  2004 KASD-LTVGKIYAAMMIMDYYKQSKVKKQRQQLEE---------QKNAPMFQRMEPSSLPQEIIA 2058

  Fly  2312 N---LDELDQEP-------------EPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQ---- 2356
            |   |..|.|:|             .|:..:  .:|..........|....|:|.:...|:    
Human  2059 NAKALPYLQQDPVSGLSGRSGYPSMSPLSPQ--DIFQLACMDPADDGQFQERQSLEPEVSELKSV 2121

  Fly  2357 --SNGALAIGGSASAALGVG-GSSLVLGSSDP--------------------AGGDYLYD-TLNR 2397
              ||..:.:........|.| .||:...:.||                    :...:|.: ::.|
Human  2122 QPSNHGIYLPSDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIRDKRSNSSWLEEFSMER 2186

  Fly  2398 SVADGVNNITRNIMQARLAAAGKLQDELQGAG-------SGGELRTFGESISMRPLAKNGGGAAT 2455
            |..:...:..|:...:...:|.:|..:   :|       |||..|  |.|...:.|         
Human  2187 SSENTYKSRRRSYHSSLRLSAHRLNSD---SGHKSDTHRSGGRER--GRSKERKHL--------- 2237

  Fly  2456 VAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQR-RLPTSSDMNG 2519
                |.|:.:..|.:.|                |.....|...:....||.:.| :.|.......
Human  2238 ----LSPDVSRCNSEER----------------GTQADWESPERRQSRSPSEGRSQTPNRQGTGS 2282

  Fly  2520 LAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSLSLIGSSNGS 2584
            |:||.|..|            ....|..|..|:...:.|:...|.::                  
Human  2283 LSESSIPSV------------SDTSTPRRSRRQLPPVPPKPRPLLSY------------------ 2317

  Fly  2585 IFGGSAGGLGGAGSGGVGGLGGSSSIRNAFGGSGSGPSSLSPQHQPYSGTLNSPPIPDNRLRRVA 2649
                                  ||.||:|  ||.|.|:..|.:..|    |.|..:..|.    |
Human  2318 ----------------------SSLIRHA--GSISPPADGSEEGSP----LTSQALESNN----A 2350

  Fly  2650 TVTTTNNNNKSQVSQNNS 2667
            .:|.::|:...|.||:.|
Human  2351 CLTESSNSPHPQQSQHAS 2368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 153/276 (55%)
Ion_trans 1137..1379 CDD:395416 140/242 (58%)
Ion_trans 1496..1809 CDD:395416 130/320 (41%)
Ion_trans 1851..2126 CDD:395416 144/279 (52%)
GPHH 2135..2188 CDD:407139 28/52 (54%)
Ca_chan_IQ 2199..2271 CDD:400901 31/74 (42%)
CACNA1EXP_016857732.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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