Protein Alignment Ca-alpha1D and CACNA1E

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: XP_016857732.1
• Gene: CACNA1E / 777
• HGNCID: 1392
• Length: 2458
• Species: Homo sapiens
• Alignment Length: 2553
• Identity: 865/2553 - (33%)
• Similarity: 1197/2553 - (46%)
• Gaps: 696/2553 - (27%)

  Fly   586 IDEQEQQHDQGDSAEEEDDDEDV-------------DEYFEEEEDDTQAF----------SPFYS 627
            :.|:|....|..:..|.|..::|             |.:|:.:|.:.|.:          |||..
Human    41 LPEEEAWRPQQCALLEADASDEVGMLPASPRAASGFDNFFQVQEGEGQGWEGAMALEAGSSPFLP 105

  Fly   628 SSAELIDNFGGGAGKFFNIM-----------------DFERGASGEGGFSPNGNGGPGSGDVSRT 675
            .|.|::....||..:..:|:                 ::|....||                :..
Human   106 VSPEVMKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGE----------------AVV 154

  Fly   676 ARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQ 740
            ||..||:||.....|..|.                  |..|.||........|.:.|......|.
Human   155 ARPGSGDGDSDQSRNRQGT------------------PVPASGQAAAYKQTKAQRARTMALYNPI 201

  Fly   741 PDRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTN 800
            |.|.     .|:||.....|.:|....::::|.|||::||.||.||||.||:....|..|....:
Human   202 PVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMS 266

  Fly   801 QTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFD 865
            :.|||.|..|:.||..|..:||:|.||:.|.|:|||||||::||.:|:.|.::||.:. .....|
Human   267 RRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTH-FNTHVD 330

  Fly   866 VKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKA 930
            ::.|||.||||||:||||:||||:||.||:||||||..|.||:.|.|:::||||||.:|||||:|
Human   331 LRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRA 395

  Fly   931 CRDEITGEYE--ENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTD 993
            |....:|..|  :...|||| ..||.||:| ..|.|||||||.|||...|:||||||:|:||||.
Human   396 CFMNNSGILEGFDPPHPCGV-QGCPAGYEC-KDWIGPNDGITQFDNILFAVLTVFQCITMEGWTT 458

  Fly   994 VLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEE 1058
            |||:..||:|:.|.|:|||.::|:|:|||:||:||||||||:|||.:.:||..|.|||.:||||.
Human   459 VLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIER 523

  Fly  1059 DLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKD---- 1119
            :|.||..||.:||::       :::     :.|:...|..| |.:....:..||...|.:|
Human   524 ELNGYRAWIDKAEEV-------MLA-----EENKNAGTSAL-EVLRRATIKRSRTEAMTRDSSDE 575

  Fly  1120 ---------------------------FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLAT 1157
                                       |....|.:|.:.|..||||.|||:::.||.|||..:|.
Human   576 HCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAI 640

  Fly  1158 EHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNT 1222
            .|:.|..||.:...|....|:|||..||.||||.:|.:.||.|.||.||..|.:|||.|.:....
Human   641 VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIF 705

  Fly  1223 GMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVF 1287
            ......|:||||.:||||:||:||||.||.|||.||::|::||.|||.|||||||:|||||||:|
Human   706 RPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLF 770

  Fly  1288 GGKFNF-DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIIL 1351
            ||:||| ||...   .|||.|..|::|||||:||||||.|||.||.:.||||| |..:.||||:|
Human   771 GGRFNFNDGTPS---ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIYFIVL 831

  Fly  1352 FICGNYILLNVFLAIAVDNLADADSLSEVEKEEE-----------------------PHDESAQK 1393
            .:.|||.||||||||||||||:|..|::.|:|||                       |..|..::
Human   832 TLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRR 896

  Fly  1394 KSH-----------------------------------------------SPT------------ 1399
            :.|                                               :||
Human   897 RRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSS 961

  Fly  1400 -------PTI--------------------------------DGMDDHLSID------------- 1412
                   |::                                ||.|...::|
Human   962 LNPLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREP 1026

  Fly  1413 ----------IDMEQQE------------------------------------------------ 1419
                      .|..|||
Human  1027 PWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQER 1091

  Fly  1420 -LDD----EDKMDHE----------TLSDEEVRE------------------------------- 1438
             ||:    |.:.|||          |:.:|..::
Human  1092 SLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHP 1156

  Fly  1439 ---------MCEEEEEVDEE----------------------GMITAR-PRRMSEVNTATKILP- 1470
                     :.|:|.|...|                      ..|||. .:..:|..:.|..:|
Human  1157 ELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPD 1221

  Fly  1471 --------------------------------------------------IPPGTSFFLFSQTNR 1485
                                                              :.|.:|.|:||.||.
Human  1222 VDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNP 1286

  Fly  1486 FRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLI 1550
            .|..||::.|...|...||..|..||..||||:|:..|.:.||||..|||.||.|||.|:::|:|
Human  1287 IRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMI 1351

  Fly  1551 SYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNA--------ISVVKILRVLRVLRPLRAIN 1607
            ..|.:|.||::.|..:|:||.:||..:|::. :.:||        |..:|.||||||||||:.|.
Human  1352 DQGLILQDGSYFRDLWNILDFVVVVGALVAF-ALANALGTNKGRDIKTIKSLRVLRVLRPLKTIK 1415

  Fly  1608 RAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLL 1672
            |...||.|..                                    |||.::|.:.||::|..|.
Human  1416 RLPKLKAVFD------------------------------------CVVTSLKNVFNILIVYKLF 1444

  Fly  1673 QFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKG 1737
            .|:||||.|||||||||.|||.||.|:.||.|.|:   |.:.:|..::.|||..:.||:|::...
Human  1445 MFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYV---DHEKNKMEVKGREWKRHEFHYDNIIWA 1506

  Fly  1738 MLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF 1802
            :||||||||.||||.:|..|:|..:|:.||..:.|..::.:|::|.::..||.|||||..:|:||
Human  1507 LLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1571

  Fly  1803 QNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMIN 1865
            |.:|::..:.|.|:||:|.||:||:.|||:.||:|  :|..||:||.||.|.||||||..:|.:|
Human  1572 QEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALN 1636

  Fly  1866 TVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFID 1930
            ||.|.||:|:.|..|...|..||:.||.||:||.|.|:.||.|.|||.|.||:||||.|:||..:
Human  1637 TVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITE 1701

  Fly  1931 IVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTF 1995
            |:.::.|..:||                  |.|:   :|.:|||..||:|||.:|..||.|||||
Human  1702 IILTDSKLVNTS------------------GFNM---SFLKLFRAARLIKLLRQGYTIRILLWTF 1745

  Fly  1996 IKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAW 2060
            ::||:|||||.|||.:||||||::||||||.|.||..:.|..:|||::|..::::||||||||||
Human  1746 VQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAW 1810

  Fly  2061 QEIMMSCSAQPDVKCDMNSDTP-----GEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDY 2120
            ||||:||..:..  |:.::..|     .|.||:.:||.||:||...||||::|||||||||||:|
Human  1811 QEIMLSCLGEKG--CEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEY 1873

  Fly  2121 LTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSM 2185
            ||||.|||||||||||:|:|:|||..|.|||.:.::..:|..:|||||.||.||.::|.||||.|
Human  1874 LTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLM 1938

  Fly  2186 NMPLNSDGTVLFNATLFAVVRTSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLLDQVVPPP 2247
            |||:..|.||.|.:||.|::||:|.|| ..|..|  ..:|||:.....||...:.|:||.:||.|
Human  1939 NMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMP 2003

  Fly  2248 GNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSP-ALKRAISG 2311
            ...| :||||.||..:|.||:::.|.:|:::..|.         |........:.| :|.:.|..
Human  2004 KASD-LTVGKIYAAMMIMDYYKQSKVKKQRQQLEE---------QKNAPMFQRMEPSSLPQEIIA 2058

  Fly  2312 N---LDELDQEP-------------EPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQ---- 2356
            |   |..|.|:|             .|:..:  .:|..........|....|:|.:...|:
Human  2059 NAKALPYLQQDPVSGLSGRSGYPSMSPLSPQ--DIFQLACMDPADDGQFQERQSLEPEVSELKSV 2121

  Fly  2357 --SNGALAIGGSASAALGVG-GSSLVLGSSDP--------------------AGGDYLYD-TLNR 2397
              ||..:.:........|.| .||:...:.||                    :...:|.: ::.|
Human  2122 QPSNHGIYLPSDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIRDKRSNSSWLEEFSMER 2186

  Fly  2398 SVADGVNNITRNIMQARLAAAGKLQDELQGAG-------SGGELRTFGESISMRPLAKNGGGAAT 2455
            |..:...:..|:...:...:|.:|..:   :|       |||..|  |.|...:.|
Human  2187 SSENTYKSRRRSYHSSLRLSAHRLNSD---SGHKSDTHRSGGRER--GRSKERKHL--------- 2237

  Fly  2456 VAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQR-RLPTSSDMNG 2519
                |.|:.:..|.:.|                |.....|...:....||.:.| :.|.......
Human  2238 ----LSPDVSRCNSEER----------------GTQADWESPERRQSRSPSEGRSQTPNRQGTGS 2282

  Fly  2520 LAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSLSLIGSSNGS 2584
            |:||.|..|            ....|..|..|:...:.|:...|.::
Human  2283 LSESSIPSV------------SDTSTPRRSRRQLPPVPPKPRPLLSY------------------ 2317

  Fly  2585 IFGGSAGGLGGAGSGGVGGLGGSSSIRNAFGGSGSGPSSLSPQHQPYSGTLNSPPIPDNRLRRVA 2649
                                  ||.||:|  ||.|.|:..|.:..|    |.|..:..|.    |
Human  2318 ----------------------SSLIRHA--GSISPPADGSEEGSP----LTSQALESNN----A 2350

  Fly  2650 TVTTTNNNNKSQVSQNNS 2667
            .:|.::|:...|.||:.|
Human  2351 CLTESSNSPHPQQSQHAS 2368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	153/276 (55%)
		Ion_trans	1137..1379	CDD:459842	140/242 (58%)
		Ion_trans	1496..1809	CDD:459842	130/320 (41%)
		Ion_trans	1851..2126	CDD:459842	144/279 (52%)
		GPHH	2135..2188	CDD:465306	28/52 (54%)
		Ca_chan_IQ	2198..2273	CDD:462591	31/77 (40%)
CACNA1E	XP_016857732.1	Ion_trans	233..507	CDD:459842	153/276 (55%)
		Ion_trans	620..859	CDD:459842	140/242 (58%)
		Ion_trans	1298..1532	CDD:459842	112/273 (41%)
		Ion_trans	1622..1879	CDD:459842	144/279 (52%)
		GPHH	1888..1941	CDD:465306	28/52 (54%)
		Ca_chan_IQ	1951..2027	CDD:462591	31/76 (41%)
		PHA03307	2123..>2345	CDD:223039	55/313 (18%)