Protein Alignment Ca-alpha1D and CACNA1D

DIOPT Version :9

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: XP_011532396.1
• Gene: CACNA1D / 776
• HGNCID: 1391
• Length: 2246
• Species: Homo sapiens
• Alignment Length: 2233
• Identity: 1137/2233 - (50%)
• Similarity: 1368/2233 - (61%)
• Gaps: 417/2233 - (18%)

  Fly   680 SGEGDLGGGNNI--------MGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQ-- 734
            ||||.....|:.        ..||:...|...:||:.:...|.|:..|:          ||||
Human    72 SGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQR----------KRQQYA 126

  Fly   735 ---RRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDS 796
               ::|.....||.|||||||:.||:|..||.|||||||:..|||.|||||:|||:|.|:|..||
Human   127 KSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDS 191

  Fly   797 NVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK 861
            |.||..||||||.||:|||.|..:||:|||.:||..||:|||||||||.||::|..|..|.||.|
Human   192 NSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTK 256

  Fly   862 D------------AFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIII 914
            :            .|||||||||||||||||||||||||||||||:||||||.||||||||||||
Human   257 ETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 321

  Fly   915 YAIIGLELFSGKLHKAC---RDEITGEYEENIRPC---GVGYQCPP-GYKCYGGWDGPNDGITNF 972
            |||||||||.||:||.|   ..:|..  ||:..||   |.|.||.. |.:|..||.|||.|||||
Human   322 YAIIGLELFIGKMHKTCFFADSDIVA--EEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNF 384

  Fly   973 DNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 1037
            |||..||||||||:|:||||||||.:.||||.:..|:||:|:||.|:|||:||:|||||||||||
Human   385 DNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 449

  Fly  1038 RNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEP--DAVGGLISDGKGK-----QPNEMDS 1095
            |.|||.||||||||||||:||||:||||||||||||:|  :..||  .:||..     ...|..:
Human   450 REKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGG--EEGKRNTSMPTSETESVN 512

  Fly  1096 TENLGEEMPEVQMTESR---------WR----------------------KMKKDFDRVNRRMRR 1129
            |||:..|      .|:|         ||                      |:.:.:.|.||..||
Human   513 TENVSGE------GENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRR 571

  Fly  1130 ACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGF 1194
            .||.||||..||||:||||||||..:::|||.|.|||...|:..|...:.|||||||:||||||.
Human   572 RCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGL 636

  Fly  1195 QGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLL 1259
            |.||||||||||||||.|.||||:|....:|.|||:||.|||||||:||||::|.||||||||||
Human   637 QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLL 701

  Fly  1260 NSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWN 1324
            ||::|||||||||||||:||:|||||:||||||||..:.| |..||.|.|||||||||:||||||
Human   702 NSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQALLTVFQILTGEDWN 765

  Fly  1325 AVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDE 1389
            ||||.||.||||.||.|.:.||||||||||||||||||||||||||||||:||:..:|||....|
Human   766 AVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKE 830

  Fly  1390 SAQ---------KKSHSP-TPTIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEE 1444
            ..:         ||::.| ...|...|:.::||...|    :|||| |.....|..|.|..||||
Human   831 RKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYRE----EDEDK-DPYPPCDVPVGEEEEEEE 890

  Fly  1445 EVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMF 1509
            |.:.|.....||||:||:|...||.|||.|::||:.|:||..||.||.|.||..|.|:||..||.
Human   891 EDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIML 955

  Fly  1510 SSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVV 1574
            |||.||||:|:|::...|.:|..|||.|||:||:|::||:.::|..||.|||||:.|||||:|||
Human   956 SSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 1020

  Fly  1575 CVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFM 1639
            .|||:|....|:|||||||||||||||||||||||||||||||||.
Human  1021 GVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVF------------------- 1066

  Fly  1640 FAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYG 1704
                             |||:||||||:||.|||||||.||||||||||::|||.:|...:||.|
Human  1067 -----------------VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRG 1114

  Fly  1705 TYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIH 1769
            .:::|.||||..|.:|||.|.|:.|:||:|...|:.|||||||||||.|||.:||||.||.|||:
Human  1115 LFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIY 1179

  Fly  1770 NFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRR 1834
            |.|..::.::||||||:||||:||||||||||||.:||:|||||:||||||.|:|:||||:|:||
Human  1180 NHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRR 1244

  Fly  1835 YIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEF 1899
            ||||:..|||.|:.|.||.|||.:|:|||:||:.|||:.|.|...:.:.:|.|||:||.||.:|.
Human  1245 YIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEM 1309

  Fly  1900 VFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSE-----------------IKSKDTSQIAEC 1947
            |.|:.||:.|.||.||||.||.:||:||.||:..||                 :.|.....|.|.
Human  1310 VLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEV 1374

  Fly  1948 DIVEG------CKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVA 2006
            :..|.      ..:...|..||.|||.|||||||||||||||:||||||||||||||||||||||
Human  1375 NPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1439

  Fly  2007 LLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQP 2071
            |||.:|||||||:|||:|||:|:...|.|..|||||||.||||:|||.||||||||||::|  .|
Human  1440 LLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLAC--LP 1502

  Fly  2072 DVKCDMNSD-TPGE--PCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHL 2133
            ...||..|| .|||  .|||:.|..||||||:||:||||||||||||||||||||||||||||||
Human  1503 GKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL 1567

  Fly  2134 DEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFN 2198
            |||.|:||||||:|||||||||||||||:|.||||||||||||:||||||:|||||||||||:||
Human  1568 DEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFN 1632

  Fly  2199 ATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYL 2263
            |||||:|||:|.|||:||::.||.||||.||:|||:|:.|||||||||.| ||||||||||||:|
Human  1633 ATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFL 1696

  Fly  2264 IQDYFRRFKKRKEQEGKEGHPDSN-TVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRRH 2327
            ||||||:|||||||.....:|..| |:.|||||||||::.|.::||||.:|.  |.|||...|..
Human  1697 IQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQ--DDEPEETKREE 1759

  Fly  2328 H-TLF---GSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSS----- 2383
            . .:|   |::..:...|.|...|.|.:.|           .:....|.|...|:...|.
Human  1760 EDDVFKRNGALLGNHVNHVNSDRRDSLQQT-----------NTTHRPLHVQRPSIPPASDTEKPL 1813

  Fly  2384 -DPAGGD-----YLYDTLNRSVADGVNNITRNIMQARLA-----AAGKLQDELQG---------- 2427
             .|||..     :.::::.:.|....|....|...::.|     :.|.|:...:.
Human  1814 FPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDR 1878

  Fly  2428 -------------------AGSG------------------------GELRTF------------ 2437
                               :.||                        ||...|
Human  1879 EPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSP 1943

  Fly  2438 --------------GESI-SMRPLAKNGGGAATVAGTLPPEANAINYDNR---NRGIL------- 2477
                          |.:| |.||     .|.....|.|..:.:.:.||:|   .|.:|
Human  1944 TWSRQNYGYYSRYPGRNIDSERP-----RGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASH 2003

  Fly  2478 --------------------------------LH------------------------------- 2479
                                            ||
Human  2004 RRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWAT 2068

  Fly  2480 -----PYNN---VYAP-------------NGALPGHERMI-----------QSTPASPYDQRRLP 2512
                 ||.:   .|.|             ||:||...|..           ..||||    ..:|
Human  2069 PPATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS----LTVP 2129

  Fly  2513 TS-----SDMNGLAESLIGGVLAAEGLGKYC-DSEFVGTAAREMREALDMTPEEMNLAAHQILSN 2571
            :|     ||....|:||:..||.:||||:|. |.:||.....|:.:|.|:|.:||..||..:|
Human  2130 SSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLL-- 2192

  Fly  2572 EHSLSLIGSSNGSIFGGSAGGLG 2594
                      ||::...:.|.:|
Human  2193 ----------NGNVRPRANGDVG 2205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	194/293 (66%)
		Ion_trans	1137..1379	CDD:395416	179/241 (74%)
		Ion_trans	1496..1809	CDD:395416	183/312 (59%)
		Ion_trans	1851..2126	CDD:395416	178/300 (59%)
		GPHH	2135..2188	CDD:407139	45/52 (87%)
		Ca_chan_IQ	2199..2271	CDD:400901	55/71 (77%)
CACNA1D	XP_011532396.1	Ion_trans	180..454	CDD:278921	181/275 (66%)
		Ion_trans	600..817	CDD:278921	164/217 (76%)
		Ion_trans	960..1219	CDD:278921	173/294 (59%)
		Ion_trans	1279..1560	CDD:278921	167/282 (59%)
		GPHH	1568..1631	CDD:293510	55/62 (89%)
		Ca_chan_IQ	1633..1704	CDD:285917	55/71 (77%)
		CAC1F_C	1728..2243	CDD:293490	100/512 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I825
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H578
Inparanoid	1	1.050	1991	1.000	Inparanoid score	I55
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48156
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	1	1.000	-	-		otm41149
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	LDO	PTHR45628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X533
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	13.010