Protein Alignment Ca-alpha1D and CACNA1C

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: XP_016875415.1
• Gene: CACNA1C / 775
• HGNCID: 1390
• Length: 2412
• Species: Homo sapiens
• Alignment Length: 2447
• Identity: 1139/2447 - (46%)
• Similarity: 1403/2447 - (57%)
• Gaps: 586/2447 - (23%)

  Fly   623 SPFYSSSAE------LIDNFGGGAGKFFNIMDFERGASGEGGFSPNGNGGPGSG-------DVSR 674
            :|.:.:|.|      |..|:|.......|:     .|:...|.:|.....||:.       |.:|
Human    57 TPSHPTSTEPCGPPTLCSNYGSPRPAHANM-----NANAAAGLAPEHIPTPGAALSWQAAIDAAR 116

  Fly   675 TARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKP 739
            .|:             :||  |.|.|.| .|::.|                    |:::|:.|||
Human   117 QAK-------------LMG--SAGNATI-STVSST--------------------QRKRQQYGKP 145

  Fly   740 QPD------RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNV 798
            :..      ||.|||.||::|||:|..||.||||||||.:|||||||||:|||:|.|:|..|||.
Human   146 KKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNA 210

  Fly   799 TNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK-- 861
            ||..||:|||:||:|||.|..:|::|||.:.|..||||||||||||.|||:|..|..|.|..|
Human   211 TNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 275

  Fly   862 ---------DAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAI 917
                     ..|||||||||||||||||||||||||||||||:||||||.|||||||||||||||
Human   276 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAI 340

  Fly   918 IGLELFSGKLHKACRDE---ITGEYEENIRPC----GVGYQCPPGYKCYGGWDGPNDGITNFDNF 975
            ||||||.||:||.|.::   .....|::..||    |.|.||..|..|..|||||..||||||||
Human   341 IGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNF 405

  Fly   976 GLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNK 1040
            ..||||||||:|:||||||||.:|||||.:..|:||:|:||.|:|||:||:||||||||||||.|
Human   406 AFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREK 470

  Fly  1041 AKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPD---------------AVGGLISDGKGK-- 1088
            ||.||||||||||||:||||:||||||||||||:|:               ...|::...|||
Human   471 AKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNRGTPAGMLDQKKGKFA 535

  Fly  1089 ---------------------------------------------------------------QP 1090
                                                                           .|
Human   536 WFSHSTETHVSMPTSETESVNTENVAGGDIEGENCGARLAKGSRSAVEPAVLLPWGVTTVNSPWP 600

  Fly  1091 NEMDSTENLGEEMPEVQMTESR----WRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLN 1151
            .|...||.|.:..|..::::|:    ||       |.||..||.||.||||..||||:|.|||||
Human   601 LEELQTEALSQTSPSHRISKSKFSRYWR-------RWNRFCRRKCRAAVKSNVFYWLVIFLVFLN 658

  Fly  1152 TGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITE 1216
            |..:|:|||.|.:||...|:..|...:.|||.||||||||||.|.||||||||||||||.|.|.|
Human   659 TLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILE 723

  Fly  1217 TLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFAL 1281
            |:|..|.:|.|||:||||||||||:||:|:||.||||||||||||::|||||||||||||:||:|
Human   724 TILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSL 788

  Fly  1282 LGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACI 1346
            ||||:||||||||..:.: |..||.|.|:|||||||:||||||:|||.||.||||.|..|.|.||
Human   789 LGMQLFGGKFNFDEMQTR-RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 852

  Fly  1347 YFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDE--------SAQKK--------- 1394
            ||||||||||||||||||||||||||||:||:..:||||...|        |.:||
Human   853 YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAV 917

  Fly  1395 ----------------SHSPTPTIDGMDDHLSIDIDMEQQELDDEDKMDH---ETLSDEEVREMC 1440
                            ..||..|...|||         .|..::|||..:   ||..:|:
Human   918 GESKEEKIELKSITADGESPPATKINMDD---------LQPNENEDKSPYPNPETTGEED----- 968

  Fly  1441 EEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILC 1505
            |||.|:.    :..|||.:||::...|.:|:|..::||:||..||||:.||.:.|.:.|.|:||.
Human   969 EEEPEMP----VGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILF 1029

  Fly  1506 CIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLD 1570
            .|:.||..||||:|::.....|.:|..||..||.:||||:.||:.:||..||.|:|||:.||:||
Human  1030 FILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILD 1094

  Fly  1571 LLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCL 1635
            ||||.|||||....|:||:||||||||||||||||||||||||||||||.||::||||||:||.|
Human  1095 LLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTL 1159

  Fly  1636 LQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQD 1700
            ||||||            |                        |||||||||.:.|:|.||.|:.
Human  1160 LQFMFA------------C------------------------IGVQLFKGKLYTCSDSSKQTEA 1188

  Fly  1701 ECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENG 1765
            ||.|.|:.|.||:|..|.::.|.|.|::|.||:|...|:.|||||||||||.|||.||||:.|:.
Human  1189 ECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDK 1253

  Fly  1766 GPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAK 1830
            |||:|:|..::.::|||||||||||:||||||||||||.:||||||||:||||||.|:|:||||:
Human  1254 GPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKAR 1318

  Fly  1831 PVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVF 1895
            |:||||||:..|||||:.|.|:.|||.:|:||::||:.|||:.|.|...:...::.|||:||.:|
Human  1319 PLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF 1383

  Fly  1896 ALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSK--DTSQIAECDIVEG------ 1952
            .:|.:.||.||:.|.||.|.||||||:||:||.||::.||....  |.....:..||.|
Human  1384 TVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIA 1448

  Fly  1953 -----------CKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVA 2006
                       |..:..:..::.|||.|||||||||||||||:||||||||||||||||||||||
Human  1449 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1513

  Fly  2007 LLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQP 2071
            ||||:|||||||:||||||||||:....|..|||||||.||||:|||.|||||||:||::|  .|
Human  1514 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC--MP 1576

  Fly  2072 DVKC----DMNSDTPGE-PCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPH 2131
            ..||    :.::.|.|| |||||.|..||||||:||:||||||||||||||||||||||||||||
Human  1577 GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH 1641

  Fly  2132 HLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVL 2196
            |||||.|:|:||||:|||||||||||||||:|.||||||||||||:||||||||||||||||||:
Human  1642 HLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVM 1706

  Fly  2197 FNATLFAVVRTSLSIKTD-------------------GNIDDANSELRATIKQIWKRTNPKLLDQ 2242
            |||||||:|||:|.|||:                   ||::.||.||||.||:|||||:.|||||
Human  1707 FNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQ 1771

  Fly  2243 VVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDS-NTVTLQAGLRTLHEVSPALK 2306
            ||||.| ||||||||||||:|||:|||:||||||| |..|.|.. |.::|||||||||::.|.::
Human  1772 VVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQ-GLVGKPSQRNALSLQAGLRTLHDIGPEIR 1834

  Fly  2307 RAISGNL---DELDQ---------EPEPMHRRHHTLFGSVWSSIRRHGNGTFRRS---------A 2350
            |||||:|   :|||:         ..:.:.||...|||:..|..:..|...|.::         .
Human  1835 RAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHIN 1899

  Fly  2351 KATASQ------SNGALAIGGSASAALGVGGSSLVLGSSD---------PAGGDYLYDTLN---- 2396
            ||.:||      |:..|.......::....||:..:.:::         |||......|:.
Human  1900 KAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGP 1964

  Fly  2397 -RSVADGVNNITRNIMQARL------------AAAGK------LQDELQGAGSG----------- 2431
             .|.|..|..:...:...|:            .|.|.      |..:|||:.:|
Human  1965 PLSPAIRVQEVAWKLSSNRMHCCDMLDGGTFPPALGPRRAPPCLHQQLQGSLAGLREDTPCIVPG 2029

  Fly  2432 ----------GELRTFG---------------ESISMRPLAKNGGGAAT---------------- 2455
                      ||....|               |.:.:|   ::.|.|.|
Human  2030 HASLCCSSRVGEWLPAGCTAPQHARERHVPMCEDLELR---RDSGSAGTQAHCLLLRRANPSRCH 2091

  Fly  2456 -------VAG------------------------------------------TLPPEANAINYDN 2471
                   :||                                          |||.|.......:
Human  2092 SRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQS 2156

  Fly  2472 RNRGIL----------LH--------------------PYNNVYAPNGALPGHERMIQ------- 2499
            ..||.|          .|                    |.:.|:....|:.|...::|
Human  2157 PKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPAS 2221

  Fly  2500 ------STPASP----YDQRRLPT-------SSD------------------------------- 2516
                  :.||:|    :..:.:||       ||:
Human  2222 FPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVR 2286

  Fly  2517 ----------------MNGLAESLIGGVLAAEGLGKYC-DSEFVGTAAREMREALDMTPEEMNLA 2564
                            .:|.|.||:..||.:||||::. |.:|:....:|:.:|.|||.|||..|
Human  2287 PVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESA 2351

  Fly  2565 AHQILSNEHSLSLIGSSNGSIF-------GGS--AGGLGGAG 2597
            |..|||.    ....|.||::.       .|.  |||...||
Human  2352 ADNILSG----GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	193/292 (66%)
		Ion_trans	1137..1379	CDD:459842	176/241 (73%)
		Ion_trans	1496..1809	CDD:459842	176/312 (56%)
		Ion_trans	1851..2126	CDD:459842	175/298 (59%)
		GPHH	2135..2188	CDD:465306	45/52 (87%)
		Ca_chan_IQ	2198..2273	CDD:462591	57/93 (61%)
CACNA1C	XP_016875415.1	Ion_trans	179..472	CDD:459842	193/292 (66%)
		Ion_trans	644..885	CDD:459842	176/241 (73%)
		Ion_trans	1020..1297	CDD:459842	176/312 (56%)
		Ion_trans	1339..1636	CDD:459842	175/298 (59%)
		GPHH	1645..1698	CDD:465306	45/52 (87%)
		Ca_chan_IQ	1708..1801	CDD:462591	57/93 (61%)
		CAC1F_C	2028..2362	CDD:465298	55/340 (16%)