DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and CACNA1B

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_000709.1 Gene:CACNA1B / 774 HGNCID:1389 Length:2339 Species:Homo sapiens


Alignment Length:2425 Identity:856/2425 - (35%)
Similarity:1156/2425 - (47%) Gaps:598/2425 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   704 ETMNGTTIGPSGAGGQKGGAAAGAAG---------------QKRQQRRG-----KPQPDRP---- 744
            :.:.|...||.|....:||.|.||.|               |...||..     .|.|.:.    
Human     6 DELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFT 70

  Fly   745 -QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEY 808
             .|:||..|..|.:|....||.||.|||::||.||.||||.||:....|..|....::.|:..|.
Human    71 VNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEP 135

  Fly   809 VFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFR 873
            .|:.||..|..:||:|.|||.|.|:|||||||::||.:|:.|.::||.:.     ||::.|||.|
Human   136 YFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVR 195

  Fly   874 VLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGE 938
            |||||:||||:|||||||.||:||||||..|.||:.|.|:::||||||.:.||.||||....|..
Human   196 VLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDA 260

  Fly   939 YEENIRPCG---VGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQD 1000
            ......|||   ....|....:|...|.|||.|||||||...|:||||||:|:|||||:||:..|
Human   261 EPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTND 325

  Fly  1001 AMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLD 1065
            |.|:.|.|:|||.::|:|:||::||:||||||||:|||.:.:||..|.|||.:||||.:|.|||:
Human   326 AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLE 390

  Fly  1066 WITQAEDI---EPDAVGGLISDGKGKQPNEM---DSTENLGEEMPEVQMTESRWRKM-------- 1116
            ||.:||::   |.|      .:.:.|.|.::   .:|:....::...:..|.|:..:        
Human   391 WIFKAEEVMLAEED------RNAEEKSPLDVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFA 449

  Fly  1117 -----------KKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQ 1170
                       ...|.|..:..|...|:.||:|:|||:::.:|.|||..:|..||.|...|....
Human   450 RASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTL 514

  Fly  1171 EYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRC 1235
            .:....|:|||..||.||||.||.:.||.|.||.||..|::||:.|.:..........|:||||.
Human   515 YFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRA 579

  Fly  1236 VRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKY 1300
            :||||:|||||||.||.|||.|||||::||.|||.|||||||:|||||||:|||:|||  ::|..
Human   580 LRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETP 642

  Fly  1301 RMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLA 1365
            ..|||.|..|:||||||:||||||||||.||.:.||||. |..:..|||:|.:.|||.|||||||
Human   643 TTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSK-GMFSSFYFIVLTLFGNYTLLNVFLA 706

  Fly  1366 IAVDNLADADSLSEVEKEEEPHDESAQK------------------------------------- 1393
            |||||||:|   .|:.|:||..:|:|.:                                     
Human   707 IAVDNLANA---QELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVW 768

  Fly  1394 -----------------------------------------KSHSPTPTI--------------- 1402
                                                     |:|...|.:               
Human   769 EQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGK 833

  Fly  1403 ---------DGMD----DHLSIDIDMEQQELDDEDKMD--------------------------- 1427
                     :|:|    .|...|.| :.....|:|:.:                           
Human   834 ARPEAAEAPEGVDPPRRHHRHRDKD-KTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAA 897

  Fly  1428 ----------------------------------------------------------------- 1427
                                                                             
Human   898 GPPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGP 962

  Fly  1428 --------------------------HETLSDEEVREMCEEEE----EVDEE------------- 1449
                                      ||.:..|...:...|:|    |.|:|             
Human   963 RAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNHQPREPHC 1027

  Fly  1450 -----GMITARP-------------------------RRMS----EVNTATKI------------ 1468
                 |.:|..|                         .||.    :.||...|            
Human  1028 DLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHIPVMLTGPLGEAT 1092

  Fly  1469 -----------------------------LPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIIL 1504
                                         .||.|.:|.|..|.||..|.|||::.....|..:||
Human  1093 VVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVIL 1157

  Fly  1505 CCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLL 1569
            ..|..||..||||:|:|.:...|..|...||.||.|||.|:::|:|..|.:||.||:.|..:|:|
Human  1158 VVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNIL 1222

  Fly  1570 DLLVVCVSLISLV---SSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVL 1631
            |.:||..:|::..   |....|:.:|.||||||||||:.|.|...||.|..              
Human  1223 DFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFD-------------- 1273

  Fly  1632 VTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSK 1696
                                  |||.::|.:.||::|..|..|:||||.|||||||||.|||.||
Human  1274 ----------------------CVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESK 1316

  Fly  1697 MTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSN 1761
            ..:.:|.|.||.|:..:|   ..:.|:|....||:|:|...:||||||||.||||.:|..|:|:.
Human  1317 ELERDCRGQYLDYEKEEV---EAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDAT 1378

  Fly  1762 KENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFA 1826
            .|..||...:|..::.:|::|.::..||.|||||..:|:|||.:|::....|.|:||:|.||:||
Human  1379 YEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFA 1443

  Fly  1827 LKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNM 1889
            :.|||:.||:|  :...|||.|.||.|..|||.|..:|.:|||.|.||||:.|..|..:|..||:
Human  1444 ISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNI 1508

  Fly  1890 IFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCK 1954
            :||::|::|.|.|:.||...|||.||||||||:.||||..||:.:|        |||.       
Human  1509 VFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTE--------IAET------- 1558

  Fly  1955 STKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVV 2019
                   :|.|:::|.||||..||:|||.:|..||.|||||::||:|||||.|||.:||||||::
Human  1559 -------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1616

  Fly  2020 GMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGE 2084
            ||||||.||||...:|..:|||:||.||:::||||||||||.|||:||.:  :..||..::  ..
Human  1617 GMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLS--NQACDEQAN--AT 1677

  Fly  2085 PCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKG 2149
            .|||..||.||:||..|||||::|||||||||||:|||||.|||||||||||||:|:||||.|.|
Human  1678 ECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACG 1742

  Fly  2150 RIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPL-NSDGTVLFNATLFAVVRTSLSIK- 2212
            ||.:.|:..:|:.:|||||.||.||.|:|.||||.||||: |.|.||.|.:||.|::||:|.|| 
Human  1743 RISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKL 1807

  Fly  2213 ----TDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKK 2273
                |..:..||  |||..|..:|.....|.||.:| ||...||:||||.||..:|.|::::.|.
Human  1808 APAGTKQHQCDA--ELRKEISVVWANLPQKTLDLLV-PPHKPDEMTVGKVYAALMIFDFYKQNKT 1869

  Fly  2274 RKE--QEGKEGHPDSNTVTLQAGLR-TLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVW 2335
            .::  |:...|......|:|...|: ||.:..||:.|                            
Human  1870 TRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR---------------------------- 1906

  Fly  2336 SSIRRHGNGTFRRSAKATASQSNGAL---AIGGSASAALGV----------------GGSS-LVL 2380
                  |...|.|...:|:..:.||:   ..|...|.:.|.                |.|: :.:
Human  1907 ------GARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPV 1965

  Fly  2381 GSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFGESISMRP 2445
            |.|.....|....::.|...||....... .|.|.|:..:|..|.|.......::....:::.||
Human  1966 GRSGALAVDVQMQSITRRGPDGEPQPGLE-SQGRAASMPRLAAETQPVTDASPMKRSISTLAQRP 2029

  Fly  2446 LAKNGGGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRR 2510
               .|....:.....||.:.|.::.:.:|   .|...:         ..:|.::..|:       
Human  2030 ---RGTHLCSTTPDRPPPSQASSHHHHHR---CHRRRD---------RKQRSLEKGPS------- 2072

  Fly  2511 LPTSSDMNGLAESLIG-GVLAAEG-LGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNE- 2572
              .|:||:|...|.:| |:...|| .|  |..|      ||.|:....:.|....::.   |:| 
Human  2073 --LSADMDGAPSSAVGPGLPPGEGPTG--CRRE------RERRQERGRSQERRQPSSS---SSEK 2124

  Fly  2573 ---HSLSLIG------------SSNGSIFGGSAGGLGGAGSGGVGG---LGGSSSIRNAFGGSGS 2619
               :|....|            |...|...|...|....|||.|.|   |..|.:.....||...
Human  2125 QRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQ 2189

  Fly  2620 GPSS-LSPQHQPYSGTLNSPPIPDNRLRRVATVTTTNNNNKSQVSQNNSNSLNVRANANSQMNMS 2683
            .|.: |:|:......|.||.||     ......|:....:..::|:..|..       |:.:...
Human  2190 LPQTPLTPRPSITYKTANSSPI-----HFAGAQTSLPAFSPGRLSRGLSEH-------NALLQRD 2242

  Fly  2684 PTGQPVQQQS-----PLRGQ 2698
            |..||:...|     |..||
Human  2243 PLSQPLAPGSRIGSDPYLGQ 2262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 147/277 (53%)
Ion_trans 1137..1379 CDD:395416 138/241 (57%)
Ion_trans 1496..1809 CDD:395416 126/315 (40%)
Ion_trans 1851..2126 CDD:395416 149/274 (54%)
GPHH 2135..2188 CDD:407139 32/52 (62%)
Ca_chan_IQ 2199..2271 CDD:400901 32/76 (42%)
CACNA1BNP_000709.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 10/30 (33%)
I 82..359 147/281 (52%)
Ion_trans 112..367 CDD:278921 135/259 (52%)
Binding to the beta subunit. /evidence=ECO:0000250 379..396 10/16 (63%)
II 468..712 138/246 (56%)
Ion_trans 499..720 CDD:278921 131/226 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..1038 18/222 (8%)
DUF3628 <822..929 CDD:289100 7/107 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1054..1076 2/21 (10%)
III 1137..1419 127/320 (40%)
Ion_trans 1167..1425 CDD:278921 120/296 (41%)
IV 1456..1711 148/280 (53%)
Ion_trans 1488..1719 CDD:278921 140/256 (55%)
GPHH 1727..1791 CDD:293510 39/63 (62%)
Ca_chan_IQ 1793..1867 CDD:285917 32/76 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1968 9/51 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1981..2206 55/260 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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